A5046381833- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Acute Lymphoblastic Leukemia research
- Lung Cancer Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Pulmonary Hypertension Research and Treatments
- CAR-T cell therapy research
- Acute Myeloid Leukemia Research
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Fungal Infections and Studies
- Helicobacter pylori-related gastroenterology studies
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Antifungal resistance and susceptibility
- HER2/EGFR in Cancer Research
- Global Health Care Issues
- Meningioma and schwannoma management
- Folate and B Vitamins Research
- COVID-19 Clinical Research Studies
- Microtubule and mitosis dynamics
- Cell death mechanisms and regulation
- Biochemical and Molecular Research
Lund University
2011-2025
Sterling Hospitals
2004-2024
Yale University
2024
Government Medical College
2023-2024
University of South Florida
2019-2024
Smt. N.H.L. Municipal Medical College
2023
Guru Ghasidas Vishwavidyalaya
2023
Oxford Dental College and Hospital
2014-2022
Johns Hopkins University
2020
Emory University Hospital
2018
Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development high-resolution, genome-wide approaches are now spurring systematic efforts to characterize cancer genomes. Here we report a large-scale project copy-number primary lung adenocarcinomas. By analysis large collection tumours (n = 371) using dense single nucleotide polymorphism arrays, identify total 57 significantly recurrent events. We find that 26 39 autosomal...
Comprehensive knowledge of the genomic alterations that underlie cancer is a critical foundation for diagnostics, prognostics, and targeted therapeutics. Systematic efforts to analyze genomes are underway, but analysis hampered by lack statistical framework distinguish meaningful events from random background aberrations. Here we describe systematic method, called Genomic Identification Significant Targets in Cancer (GISTIC), designed analyzing chromosomal aberrations cancer. We use it study...
Atrial fibrillation after cardiac surgery is associated with increased rates of death, complications, and hospitalizations. In patients postoperative atrial who are in stable condition, the best initial treatment strategy--heart-rate control or rhythm control--remains controversial.Patients new-onset were randomly assigned to undergo either rate control. The primary end point was total number days hospitalization within 60 randomization, as assessed by Wilcoxon rank-sum test.Postoperative...
Somatic genetic alterations in cancers have been linked with response to targeted therapeutics by creation of specific dependency on activated oncogenic signaling pathways. However, no tools currently exist systematically connect such lesions therapeutic vulnerability. We therefore developed a genomics approach identify associated therapeutically relevant oncogene dependency. Using integrated genomic profiling, we demonstrated that the genomes large panel human non-small cell lung cancer...
As the coronavirus disease 2019 (COVID-19) continues to be a global pandemic, policy makers have enacted and reversed non-pharmaceutical interventions with various levels of restrictions limit its spread. Data driven approaches that analyze temporal characteristics pandemic dependence on regional conditions might supply information support implementation mitigation suppression strategies. To facilitate research in this direction example United States, we present machine-readable dataset...
Abstract Mutation-specific cancer therapy has shown promising clinical efficacy. In non–small-cell lung (NSCLC), the presence of mutations in epidermal growth factor receptor (EGFR) tyrosine kinase correlates with response to small-molecule inhibitors. Here, we show that cells harboring G776insV_G/C mutation related ERBB2 (also known as HER2 or Neu), present a small percentage NSCLCs, are sensitive HKI-272, an irreversible dual-specific inhibitor targeting both EGFR and ERBB2. ERBB2-mutant...
ABSTRACT GTP cyclohydrolase I (GCYH-I) is an essential Zn 2+ -dependent enzyme that catalyzes the first step of de novo folate biosynthetic pathway in bacteria and plants, 7-deazapurine Bacteria Archaea , biopterin mammals. We recently reported discovery a new prokaryotic-specific GCYH-I (GCYH-IB) displays no sequence identity to canonical present ∼25% bacteria, majority which lack (renamed GCYH-IA). Genomic genetic analyses indicate those organisms possessing both enzymes, e.g., Bacillus...
Abstract The deregulation of BCL2 family proteins is a key contributor to the development T-cell acute lymphoblastic leukemia (T-ALL). Pharmacological inhibition these proteins, particularly through BCL2-specific inhibitor venetoclax, has emerged as promising therapeutic approach. However, clinical efficacy venetoclax often compromised due primary and acquired resistance mechanisms that remain incompletely understood. We employed deep tabular learning algorithm develop drug sensitivity...
Background: Cytokine release storm (CRS) in severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is thought to be the cause for organ damage and death which independent of actual viral burden. Tocilizumab (TCZ), an interleukin-6 receptor antagonist, approved treatment CRS. We describe efficacy safety TCZ SARS CoV-2 pneumonia. Methods: This retrospective study was conducted at a tertiary care hospital from April 20 2020 May 21 2020. The primary endpoint cumulative incidence composite...
3021 Background: The PI3K-PTEN-AKT signaling pathway is deregulated in a wide variety of cancers. GDC-0941 potent inhibitor class I PI3K and demonstrates broad activity preclinical xenograft models. Methods: A 2-stage phase study was initiated (GDC4254g). Stage 1 utilized 3+3 escalation design patients (pts) with advanced solid tumors. 2 an expansion including pts multiple myeloma, PIK3CA mutant (mt) tumors, tumors evaluable by magnetic resonance imaging (MRI) methods. single dose...
The PI3K/mTOR pathway is the second most frequently deregulated in a majority of cancers such as breast cancer, lung and melanomas well leukemia. Mutations genes coding for receptor tyrosine kinases (RTKs) G-protein-coupled receptors (GPCRs) are quite common all forms acute This can be major cause deregulation PI3K-mTOR pathway. To understand how cells display resistance to dual inhibitor, we used panel 25 leukemia cell lines. We observed that while number lines displayed sensitivity...
Therapy resistance remains one of the major challenges for cancer treatment that largely limits benefits and patient survival. The underlying mechanisms lead to therapy are highly complicated because specificity subtype therapy. expression anti-apoptotic protein BCL2 has been shown be deregulated in T-cell acute lymphoblastic leukemia (T-ALL), where different T-ALL cells display a differential response BCL2-specific inhibitor venetoclax. In this study, we observed family genes, such as BCL2,...
Arsenic is a major contaminating heavy metal due to its frequent occurrence and toxicity. Out of different remediation approaches, bioremediation using bacteria has been extensively studied. In this study, 29 bacterial isolates were screened for their arsenic tolerance capacity. One the isolate, MUM2 showed maximum (10mM). Antioxidant enzymes assayed in isolate under stress. Although, CAT activity was found increase significantly, SOD significant decrease 9mM The results obtained suggest...
Abstract Glucocorticoids, such as dexamethasone and prednisolone, are widely used in cancer treatment. Different hematological malignancies respond differently to this treatment which, could be expected, correlates with outcome. In study, we have a glucocorticoid-induced gene signature develop deep learning model that can predict sensitivity. By combining expression data from cell lines patients acute lymphoblastic leukemia, observed the is useful for classification of patients. Predicted...