A5064398262- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Immune Cell Function and Interaction
- Eosinophilic Disorders and Syndromes
- Chronic Myeloid Leukemia Treatments
- Angiogenesis and VEGF in Cancer
- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- RNA and protein synthesis mechanisms
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Breast Cancer Treatment Studies
- Atherosclerosis and Cardiovascular Diseases
- Asthma and respiratory diseases
- Glycosylation and Glycoproteins Research
- RNA Research and Splicing
- Lymphatic System and Diseases
- Ion Transport and Channel Regulation
- RNA modifications and cancer
- Immune Response and Inflammation
- Lymphoma Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Complement system in diseases
Institut de Pharmacologie et de Biologie Structurale
2015-2024
Université Toulouse III - Paul Sabatier
2015-2024
Université de Toulouse
2015-2024
Centre National de la Recherche Scientifique
2015-2024
La Ligue Contre le Cancer
2023-2024
Laboratoire de Microbiologie et Génétique Moléculaires
2002-2018
Laboratoire Excell
2017
Centre de Recherche en Cancérologie de Toulouse
2015
Établissement Français du Sang
2014
Inserm
2010-2014
Background Interleukin-33 (IL-33) is an IL-1-like cytokine ligand for the IL-1 receptor-related protein ST2, that activates mast cells and Th2 lymphocytes, induces production of Th2-associated cytokines in vivo. We initially discovered IL-33 as a nuclear factor (NF-HEV) abundantly expressed high endothelial venules from lymphoid organs, associates with chromatin exhibits transcriptional regulatory properties. This suggested that, similarly to IL-1α chromatin-associated HMGB1, may act both...
Recent studies indicate that IL-1α functions intracellularly in pathways independent of its cell surface receptors by translocating to the nucleus and regulating transcription. Similarly, chromatin-associated protein HMGB1 acts as both a nuclear factor secreted proinflammatory cytokine. Here, we show IL-33, an IL-1-like cytokine signals via IL-1 receptor-related ST2 induces T helper type 2-associated cytokines, is endothelium-derived, with transcriptional repressor properties. We found IL-33...
IL-33 is a chromatin-associated cytokine of the IL-1 family that has recently been linked to many diseases, including asthma, rheumatoid arthritis, atherosclerosis, and cardiovascular diseases. signals through receptor-related protein ST2 drives production pro-inflammatory T helper type 2-associated cytokines in mast cells, 2 lymphocytes, basophils, eosinophils, invariant natural killer cells. It currently believed IL-33, like IL-1beta IL-18, requires processing by caspase-1 mature form...
Interleukin-33 (IL-33) (NF-HEV) is a chromatin-associated nuclear cytokine from the IL-1 family, which has been linked to important diseases, including asthma, rheumatoid arthritis, ulcerative colitis, and cardiovascular diseases. IL-33 signals through ST2 receptor drives production in type 2 innate lymphoid cells (ILCs) (natural helper cells, nuocytes), T-helper (Th)2 lymphocytes, mast basophils, eosinophils, invariant natural killer T (iNKT), (NK) cells. We others recently reported that,...
The mechanisms governing infiltration of lymphocytes into tumors remain poorly characterized, in spite the critical impact these cells on patient prognosis and therapeutic responses. High endothelial venules (HEV) are blood vessels found lymphoid tissues, specialized lymphocyte recruitment, but their implications human cancer unknown. In this article, we report presence MECA 79(+) displaying all phenotypic characteristics HEVs most 319 primary solid tumors, including melanomas, breast,...
Abstract IL-33 (previously known as NF from high endothelial venules) is an IL-1 family cytokine that signals through the ST2 receptor and drives production in mast cells, basophils, eosinophils, invariant NKT NK Th2 lymphocytes, type 2 innate immune cells (natural helper nuocytes, cells). Little about endogenous IL-33; for instance, cellular sources of mouse tissues have not yet been defined. In this study, we generated Il-33–LacZ gene trap reporter strain (Il-33Gt/Gt) used novel tool to...
Significance Interleukin-33 (IL-33) is an IL-1 family cytokine with important roles in type-2 immunity and human asthma. IL-33 a key activator of the recently described group-2 innate lymphoid cells (ILC2s), which are involved initiation allergic inflammation. Here, we investigated mechanisms regulating activity. We discovered that mast cells, critical effector disorders, secrete proteases, cleave generate mature forms increased biological demonstrate these 30-fold more potent than...
Abstract IL‐33 has recently been identified as a cytokine endowed with pro‐Th2 functions, raising the question of its effect on invariant natural killer T cell (iNKT), which are potent IL‐4 producers. Here, we report two‐fold increase iNKT‐cell counts in spleen and liver after 7‐day treatment mice IL‐33, results from direct effect, given that purified iNKT cells express T1/ST2 receptor constitutively respond to by vitro expansion functional activation. Conversely expected induced...
Chronic obstructive lung disease is characterized by persistent abnormalities in epithelial and immune cell function that are driven, at least part, infection. Analysis of parainfluenza virus infection mice revealed an unexpected role for innate cells IL-13–dependent chronic disease, but the upstream driver axis this model humans with similar was undefined. We demonstrate here levels IL-33 selectively increased postviral very severe pulmonary (COPD). In mouse model, IL-33/IL-33 receptor...
Prevalence of asthma is higher in women than men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) key regulators type inflammatory responses. Here, we show that ILC2 development greatly influenced by male hormones. Male mice have reduced numbers progenitors (ILC2Ps) and mature ILC2s peripheral tissues compared with females. In consequence, males exhibit susceptibility to allergic airway inflammation response environmental allergens less severe...
Recruitment of lymphocytes into tumors is critical for anti-tumor immunity and efficacious immunotherapy. We show in murine models that tumor-associated high endothelial venules (TA-HEVs) are major sites lymphocyte entry at baseline upon treatment with anti-PD-1/anti-CTLA-4 immune checkpoint blockade (ICB). TA-HEV cells (TA-HECs) derive from post-capillary venules, co-express MECA-79+ HEV sialomucins E/P-selectins, associated homing infiltration various T cell subsets. Intravital microscopy...
Antibiotics (ABX) compromise the efficacy of programmed cell death protein 1 (PD-1) blockade in cancer patients, but mechanisms underlying their immunosuppressive effects remain unknown. By inducing down-regulation mucosal addressin adhesion molecule (MAdCAM-1) ileum, post-ABX gut recolonization by Enterocloster species drove emigration enterotropic α4β7+CD4+ regulatory T 17 cells into tumor. These deleterious ABX were mimicked oral gavage species, genetic deficiency, or antibody-mediated...
<h3>Objective</h3> Inflammatory bowel diseases (IBD) have been intrinsically linked to a deregulated cytokine network, but novel therapeutic principles are urgently needed. Here we identify the interleukin (IL)-33 and its receptor ST2 as key negative regulators of wound healing permeability in colon mice. <h3>Design</h3> Expression IL-33 was determined by qRT-PCR, ELISA, immunohistochemistry western-blot analysis. Wild-type <i>St2</i><sup>−/−</sup> mice were used experiments two experimental...