A5026990870- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Multiple Myeloma Research and Treatments
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Angiogenesis and VEGF in Cancer
- Immune cells in cancer
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Protein Degradation and Inhibitors
- Chemokine receptors and signaling
- Melanoma and MAPK Pathways
- Nanoplatforms for cancer theranostics
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Lung Cancer Research Studies
- Glycosylation and Glycoproteins Research
- Cancer Mechanisms and Therapy
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- Quinazolinone synthesis and applications
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
Université Toulouse III - Paul Sabatier
2008-2025
Centre de Recherche en Cancérologie de Toulouse
2015-2025
Centre National de la Recherche Scientifique
2010-2025
Centre Hospitalier Universitaire de Toulouse
2022-2025
Inserm
2015-2025
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Institut universitaire du cancer de Toulouse Oncopole
2018-2024
Cultures et Environnements. Préhistoire, Antiquité, Moyen Âge
2019
QIMR Berghofer Medical Research Institute
2013-2016
Institut National de Recherche en Santé Publique
2015
The mechanisms governing infiltration of lymphocytes into tumors remain poorly characterized, in spite the critical impact these cells on patient prognosis and therapeutic responses. High endothelial venules (HEV) are blood vessels found lymphoid tissues, specialized lymphocyte recruitment, but their implications human cancer unknown. In this article, we report presence MECA 79(+) displaying all phenotypic characteristics HEVs most 319 primary solid tumors, including melanomas, breast,...
CD96 has recently been shown as a negative regulator of mouse natural killer (NK)-cell activity, with Cd96(-/-)mice displaying hyperresponsive NK cells upon immune challenge. In this study, we have demonstrated that blocking monoclonal antibody inhibited experimental metastases in three different tumor models. The antimetastatic activity anti-CD96 was dependent on cells, CD226 (DNAM-1), and IFNγ, but independent activating Fc receptors. Anti-CD96 more effective combination anti-CTLA-4,...
The presence of tumor-infiltrating lymphocytes (TILs) is a strong prognostic parameter for local dissemination and overall survival in melanoma. Lymphocyte migration from blood into peripheral tissues mainly regulated by vascular endothelium. However, the vessels mechanisms governing recruitment TILs melanoma tumors remain poorly understood. Here, we show that high endothelial venules (HEVs), specialized lymphocyte extravasation lymphoid tissues, are frequently found associated with levels...
Abstract Blood vessels and tumor angiogenesis are generally associated with growth poor clinical outcome of cancer patients. However, we recently discovered that some blood present within the microenvironment can be favorable prognosis. These vessels, designated high endothelial venules (HEVs), appear to facilitate destruction by allowing levels lymphocyte infiltration into tumors. In this study, investigated mechanisms regulating HEV in human breast cancer. We found lymphotoxin β was...
Multiple myeloma (MM) is an age-dependent hematological malignancy. Evaluation of immune interactions that drive MM relies on in vitro experiments do not reflect the complex cellular stroma involved pathogenesis. Here we used Vk*MYC transgenic mice, which spontaneously develop MM, and demonstrated system plays a critical role control progression response to treatment. We monitored mice had been crossed with Cd226 mutant over period 3 years found CD226 limits spontaneous development. The...
Highlights•The activating receptor DNAM-1 identifies two distinct NK cell functional subsets•DNAM-1+ NKs have enhanced IL-15 signaling and are a higher producer of cytokines•DNAM-1− producers MIP1 chemokines•DNAM-1+ differentiate into DNAM-1− through an alternative maturation pathwaySummaryNatural killer (NK) cells comprise heterogeneous population important for pathogen defense cancer surveillance. However, the significance this diversity is not fully understood. Here, we demonstrate...
BRAF(V600E) is a major oncogenic mutation found in approximately 50% of human melanoma that confers constitutive activation the MAPK pathway and increased growth. Inhibition by oncogene targeting therapy increases overall survival patients with melanoma, but unable to produce many durable responses. Adaptive drug resistance remains main limitation inhibitor clinical efficacy immune-based strategies could be useful overcome disease relapse. Tumor microenvironment greatly differs between...
CD137 (4-1BB)-activating receptor represents a promising cancer immunotherapeutic target. Yet, the cellular program driven by and its role in immune surveillance remain unresolved. Using T cell-specific deletion agonist antibodies, we found that modulates tumor infiltration of CD8+-exhausted (Tex) cells expressing PD1, Lag-3, Tim-3 inhibitory receptors. cell-intrinsic, TCR-independent signaling stimulated proliferation terminal differentiation Tex precursor through mechanism involving RelA...
As first defensive line, monocytes are a pivotal cell population of innate immunity. Monocyte activation can be relevant to range immune conditions and responses. Here we present new insights into the by series phosphonic acid-terminated, phosphorus-containing dendrimers. Various dendritic or subdendritic structures were synthesized tested, revealing basic structural requirements for monocyte activation. We showed that multivalent character acid capping dendrimers crucial targeting Confocal...
One fourth of women with HER-2(+) metastatic breast carcinoma are treated a combination regimen trastuzumab, but the frequent resistance to this Ab requires definition new means improve its bioactivity. The mechanisms action trastuzumab involve several pathways including Ab-dependent cellular cytotoxicity. Because human γδ T lymphocytes mediate cytotoxicity and can be activated further by phosphoantigens, these cells prone efficacy Abs, as recently demonstrated for CD20(+) B cell lymphomas....
Natural killer (NK) cells are naturally circulating innate lymphoid that protect against tumor initiation and metastasis contribute to immunopathology during inflammation. The signals prime NK not completely understood, and, although the importance of IFN type I is well recognized, role III comparatively very poorly studied. IL-28R-deficient mice were resistant LPS cecal ligation puncture-induced septic shock, hallmark cytokines in these disease models dysregulated absence IL-28R. more...
Abstract The monocyte-macrophage (MΦ) lineage can undergo different pathways of activation. classical priming by IFN-γ, then triggering LPS, conducts MΦ toward proinflammatory responses, whereas the alternative activation IL-4, IL-10, IL-13, or glucocorticoids directs them an anti-inflammatory, immunosuppressive phenotype. Recently, we have shown that synthetic phosphorus-containing dendrimers activate human monocytes. Here, analyzed gene expression monocytes activated acid...
The physiological functions of human TCRVgamma9Vdelta2(+) gammadelta lymphocytes reactive to non-peptide phosphoantigens contribute cancer immunosurveillance and immunotherapy. However, their regulation by mesenchymal stem cells (MSC), multipotent immunomodulatory progenitor able infiltrate tumors, has not been investigated so far. By analyzing freshly isolated primary cell lines stimulated with synthetic phosphoantigen or B-cell lymphoma in the presence MSC, we demonstrated that MSC were...