A5056728270- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Diabetes and associated disorders
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Cytomegalovirus and herpesvirus research
- Ocular Diseases and Behçet’s Syndrome
- Virus-based gene therapy research
- Inflammatory Myopathies and Dermatomyositis
- Cell Adhesion Molecules Research
- Herpesvirus Infections and Treatments
- Reproductive System and Pregnancy
- Chemokine receptors and signaling
- Immunodeficiency and Autoimmune Disorders
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- Systemic Lupus Erythematosus Research
- Immune responses and vaccinations
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HIV Research and Treatment
- Angiogenesis and VEGF in Cancer
Sorbonne Université
2015-2025
Inserm
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Centre d'Immunologie et des Maladies Infectieuses
2014-2025
Université Toulouse III - Paul Sabatier
2022-2024
Institut Curie
2024
Université Paris Sciences et Lettres
2024
Université de Toulouse
2023
Infinity (United States)
2022
Institut Toulousain des Maladies Infectieuses et Inflammatoires
2022
CD4+CD25+ immunoregulatory T cells play a pivotal role in preventing organ-specific autoimmune diseases and tolerance induction to allogeneic organ transplants. We investigated whether these could also control graft-versus-host disease (GVHD), the main complication after hematopoietic stem cell transplantation (HSCT). Here, we show that few naturally present transplant regulate GVHD because their removal from graft dramatically accelerates this disease. Furthermore, addition of freshly...
Despite a growing interest in CD4+ CD25+ regulatory T cells (Treg) that play major role self-tolerance and immunoregulation, fundamental parameters of the biology homeostasis these are poorly known. Here, we show this population is composed two Treg subsets have distinct phenotypes normal unmanipulated mice. In steady state, some remain quiescent long lifespan, order months, whereas other dividing extensively express multiple activation markers. After adoptive transfer, tissue-specific...
CD4+CD25+ regulatory T cells (Treg's) play a pivotal role in preventing organ-specific autoimmune diseases and inducing tolerance to allogeneic organ transplants. We others recently demonstrated that high numbers of Treg's can also modulate graft-versus-host disease (GVHD) if administered conjunction with hematopoietic stem cell transplantation mice. In clinical setting, it would be impossible obtain enough freshly purified from single donor have therapeutic effect. Thus, we performed...
Regulatory T cells (T reg cells) play a major role in controlling the pathogenic autoimmune process type 1 diabetes (T1D). Interleukin 2 (IL-2), cytokine which promotes cell survival and function, may thus have therapeutic efficacy T1D. We show that 5 d of low-dose IL-2 administration starting at time T1D onset can reverse established disease NOD (nonobese diabetic) mice, with long-lasting effects. Low-dose increases number pancreas induces expression cell–associated proteins including...
Abstract Asthma is characterized by chronic eosinophilic inflammation of the airways, and allergen-specific Th2 lymphocytes are thought to play a major role in development maintenance this type allergic asthma. It generally accepted that airway dendritic cells (DC) essential for stimulating naive T primary immune response inhaled Ag sensitization. We have examined DC memory secondary subsequent inflammation. In our mouse model asthma, OVA aerosol challenge OVA-sensitized mice leads...
CD137 (4-1BB)-activating receptor represents a promising cancer immunotherapeutic target. Yet, the cellular program driven by and its role in immune surveillance remain unresolved. Using T cell-specific deletion agonist antibodies, we found that modulates tumor infiltration of CD8+-exhausted (Tex) cells expressing PD1, Lag-3, Tim-3 inhibitory receptors. cell-intrinsic, TCR-independent signaling stimulated proliferation terminal differentiation Tex precursor through mechanism involving RelA...
Abstract In the normal mouse spleen, two distinct populations of dendritic cells (DC) are present that differ in microanatomical location. The major population marginal DC is found “marginal zone bridging channels” and extends into red pulp. interdigitating (IDC) localized T cell areas white aim study was to characterize these splenic with regard their phenotype, vivo phagocytic function, turnover. Both IDC CD11c+ CD13+, but only NLDC-145+ CD8α+. Notably, both populations, when freshly...
An increasing number of studies have documented the central role T cell costimulation in autoimmunity. Here we show that autoimmune diabetes-prone nonobese diabetic (NOD) mouse strain, deficient B7-2 costimulation, is protected from diabetes but develops a spontaneous peripheral polyneuropathy. All female and one third male mice exhibited limb paralysis with histologic electrophysiologic evidence severe demyelination nerves beginning at 20 wk age. No nervous system lesions were apparent. The...
CD4+CD25+Foxp3+ Tregs play a major role in prevention of autoimmune diseases. The suppressive effect on effector T cells (Teffs), the that can mediate autoimmunity, has been extensively studied. However, vivo impact Teff activation during autoimmunity not explored. In this study, we have shown CD4+ strongly boosts expansion and activity Tregs. This helper function cells, which believe to be novel, was observed pancreas draining lymph nodes mouse recipients islet-specific Teffs Its...
Radiotherapy (RT) represents one of the main anticancer approaches for treatment solid tumors. Beyond expected direct effects RT on tumor cells, evidence supporting importance an immune response to is growing. The balance between RT-mediated immunogenic and tolerogenic activity ill-defined deserves more attention. Herein, a murine model head neck squamous cell carcinoma was used demonstrate that upregulated CCL2 chemokine production in leading CCR2-dependent accumulation necrosis factor...
Abstract Background Endothelial progenitor cells (EPCs) are non-differentiated endothelial (ECs) present in blood circulation that involved neo-vascularization and correction of damaged sites. Since EPCs from patients with vascular disorders impaired inefficient, allogenic sources adult or cord considered as good alternatives. However, due to the reaction immune system against which usually lead their elimination, we focused on exact role cells, particularly, T most important applied...
Abstract Several drugs targeting members of the TNF superfamily or receptor (TNFRSF) are widely used in medicine currently being tested therapeutic trials. However, their mechanism action remains poorly understood. Here, we explored effects TNFRSF co‐stimulation on murine Foxp3 + regulatory T cell (Treg) biology, as they pivotal modulators immune responses. We show that engagement TNFR2, 4‐1BB, GITR, and DR3, but not OX40, increases Treg proliferation survival. Triggering these Tregs induces...