A5073661192- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Breast Lesions and Carcinomas
- BRCA gene mutations in cancer
- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Advances in Oncology and Radiotherapy
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Cancer survivorship and care
- Cancer Cells and Metastasis
- Lymphatic System and Diseases
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Multiple and Secondary Primary Cancers
- Bone health and treatments
- Estrogen and related hormone effects
- Cancer Diagnosis and Treatment
- Head and Neck Cancer Studies
- Reconstructive Surgery and Microvascular Techniques
- Advanced Breast Cancer Therapies
- Nutrition, Genetics, and Disease
- Chromatin Remodeling and Cancer
Roswell Park Comprehensive Cancer Center
2012-2024
Rutgers, The State University of New Jersey
2019-2024
Rutgers Cancer Institute of New Jersey
2019-2024
Memorial Sloan Kettering Cancer Center
2010-2024
Westmead Hospital
2023
Chris O’Brien Lifehouse
2023
University at Buffalo, State University of New York
2014
Centre for Rural Education and Economic Development
2005
Triple-negative (TN) breast cancer is an aggressive subtype of associated with a unique set epidemiologic and genetic risk factors. We conducted two-stage genome-wide association study TN (stage 1: 1529 cases, 3399 controls; stage 2: 2148 1309 controls) to identify loci that influence risk. Variants in the 19p13.1 PTHLH showed significant associations (P < 5 × 10−8) 1 2 combined. Results also suggested substantial enrichment significantly variants among single nucleotide polymorphisms (SNPs)...
Breast cancer is the most frequently diagnosed malignancy in women United States and second only to lung as a cause of death. To assist who are at increased risk developing breast their physicians application individualized strategies reduce risk, NCCN has developed these guidelines for reduction.
Histamine receptor antagonists have been shown to induce tumor-infiltrating lymphocytes (TILs) in colonic cancers and improve survival. The role of histamine anatagonists breast cancer is unclarified.To evaluate the inducing cancer.Forty-five patients with operable (25 cases who received preoperative famotidine 20 controls) were studied for effect TILs survival cancer.Significant seen 75% (18/24) as opposed 35% (7/20) controls. In logistic regression analysis only variable found be...
Accelerated partial breast irradiation (APBI) is one of the standard treatment options in early-stage node negative cancer patients selected cases(1). Various techniques and radiation doses have been used APBI(2). Most studies shown an equivalent result with APBI carefully patients, however optimal schedule to obtain best balance between patient preference, local control, toxicity cosmesis still represents a challenge.
Highlights•A window-of-opportunity clinical trial in newly diagnosed ERα (ESR1) + breast cancer patients•Inhibition of ESR1-p53 interaction tumors by tamoxifen has implications•Reactivation wild-type p53 leads to tumor-suppressive gene expression•p53 reactivation is associated with mevalonate pathway repression signatureSummaryThe canonical mechanism behind tamoxifen's therapeutic effect on estrogen receptor α/ESR1+ cancers inhibition ESR1-dependent signaling. Although ESR1+ expressing were...
Ductal carcinoma in situ (DCIS) is a heterogeneous and complex disorder that has changed greatly as an entity over the past few decades. Despite overall favorable prognosis evidence-based recommendations from randomized trials, clinical management of DCIS varies considerably among surgeons. While goal to achieve maximal local control with minimal morbidity, surgeons at times both over- undertreat these patients. Currently, rates mastectomy contralateral prophylactic have been dramatically...
Postmastectomy radiation therapy (PMRT) decreases the risk of locoregional recurrence and increases overall survival rates in patients with high-risk node positive breast cancer. While number cancer treated proton-based PMRT has increased recent years, there is limited data on use proton postmastectomy reconstruction setting. In this study, we compared acute toxicities reconstructive complications photon-based PMRT.A retrospective review our institutional database was performed to identify...
Bisphosphonates such as zoledronic acid are an important part of adjuvant therapy to reduce the risk recurrence in early-stage breast cancer. Uveitis remains one lesser-known side effects acid; prompt recognition is essential ensure patients receive appropriate and timely care help prevent permanent vision loss. We report a case anterior uveitis postmenopausal woman who presented with visual symptoms after receiving first dose acid. This serves educate increase awareness given only reported...
Abstract BACKGROUND: HER2-positive breast cancers, which accounts for 20% of is associated with aggressive clinical behavior and inferior survival. The approval HER2 targeted therapy has changed the landscape this disease reduced recurrence by 50% improved survival 33%. (1) However, cardiotoxicity a well-recognized adverse event HER2-targeted therapies. Adjuvant trastuzumab emtansine (TDM1) current standard care patients residual cancer after neoadjuvant therapy. TDM1 risk defined as decline...