A5071074432- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Breast Cancer Treatment Studies
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Digital Radiography and Breast Imaging
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Chemokine receptors and signaling
- Retinoids in leukemia and cellular processes
- Advanced biosensing and bioanalysis techniques
- AI in cancer detection
- HER2/EGFR in Cancer Research
- Genetic Syndromes and Imprinting
- Advanced Biosensing Techniques and Applications
City of Hope
2016-2025
Beckman Research Institute
2017-2024
Hoopes Vision
2024
City Of Hope National Medical Center
2017-2021
Duke Medical Center
2007-2019
Duke University
2009-2019
Duke University Hospital
2009-2016
Princess Margaret Cancer Centre
2015
University Health Network
2015
Indiana University School of Medicine
2014
Abstract Obesity is one of the most important preventable causes cancer and significant risk factor for breast in postmenopausal women. Compared with lean women, obese women are more likely to be diagnosed a larger, higher grade tumor, an increased incidence lymph node metastases, elevated distant recurrence. However, mechanisms connecting obesity pathogenesis poorly defined. Here, we show that during obesity, adipocytes within human mouse tissues recruit activate macrophages through...
This paper resulted from a conference entitled "Lactation and Milk: Defining refining the critical questions" held at University of Colorado School Medicine January 18–20, 2012. The mission was to identify unresolved questions set future goals for research into human milk composition, mammary development lactation. We first outline unanswered regarding composition (Section I) mechanisms by which components affect neonatal development, growth health recommend models research. Emerging about...
Autofluorescence spectroscopy is a powerful imaging technique that exploits endogenous fluorophores. The fluorophores NADH and flavin adenine dinucleotide (FAD) are two of the principal electron donors acceptors in cellular metabolism, respectively. optical oxidation-reduction (redox) ratio measure metabolism can be determined by NADH/FAD. We hypothesized there would significant difference redox normal mammary epithelial cells compared with breast tumor cell lines estrogen receptor...
MicroRNAs (miRNAs) have demonstrated great promise as a novel class of biomarkers for early detection various cancers, including breast cancer. However, due to technical difficulties in detecting these small molecules, miRNAs not been adopted into routine clinical practice diagnostics. Thus, it is important develop alternative strategies that could offer more advantages over conventional methods. Here, we demonstrate the application "turn-on" SERS sensing technology, referred "inverse...
Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these are not well understood. Mammary gland-associated white adipose (mgWAT) regresses of milk fat production during lactation expands subsequent involution milk-producing epithelial cells, providing one most marked physiological examples growth. We examined cellular functional implications adipocyte lipid dynamics mouse mammary gland (MG). Using vivo analysis...
Although many tumors regress in response to neoadjuvant chemotherapy, residual tumor cells are detected most cancer patients post-treatment. These thought remain dormant for years before resuming growth, resulting recurrence. Considering that recurrent often responsible patient mortality, there exists an urgent need study signaling pathways drive dormancy/recurrence. We have developed vitro model of Short-term exposure (breast or prostate) chemotherapy at clinically relevant doses enriches a...
Epigenetic mechanisms are proposed to link maternal concentrations of methyl group donor nutrients with the risk low birth weight. However, empirical data lacking. We have examined association between folate and weight assessed mediating role DNA methylation at nine differentially methylated regions (DMRs) genomically imprinted genes in these associations. Compared newborns women levels lowest quartile, was higher mothers second (β = 143.2, se 63.2, P 0.02), third 117.3, 64.0, 0.07), fourth...
Breast cancer is the most frequently diagnosed malignancy in women United States and second only to lung as a cause of death. To assist who are at increased risk developing breast their physicians application individualized strategies reduce risk, NCCN has developed these guidelines for reduction.
Abstract During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed myoepithelial cells. We hypothesize that loss of is a general manifestation epithelia are susceptible to cancer initiation. In present study, we show histologically normal breast tissue from younger women who cancer, as result harboring germline mutation BRCA1 , BRCA2 or PALB2 genes, exhibits hallmarks accelerated aging. These include proportionately...
Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling reduced relapse-free survival. Concordant expression HMGA2 and EZH2 proteins is observed
Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor-positive (ER(+)) development, but receptor-negative (ER(-)) remains an unmet challenge due to gaps pathobiologic understanding. In this study, we used reverse-phase protein array identify activation Src kinase as early signaling alteration premalignant lesions women who did not respond...
Lung cancer is the third most common with Black/AA men showing higher risk and poorer outcomes than NHW men. disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, molecular determinants including biological genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating prognosis have been observed many cancers. Most importantly, our study shows that PRMT6 displays expression lung tissues compared...
Triple-negative breast cancer is a prevalent subtype with the lowest 5-year survival. Several factors contribute to its treatment response, but inherent molecular and cellular tumor heterogeneity are increasingly acknowledged as crucial determinants. Spatial transcriptomic profiling was performed on FFPE tissues from retrospective, treatment-naive group of women differential prognoses (17 >15 years survival-good prognosis (GPx) 15 <3 survival-poor (PPx)) using GeoMX ® Digital Profiler....