A5080229565- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer Cells and Metastasis
- BRCA gene mutations in cancer
- Ethics in Clinical Research
- Breast Cancer Treatment Studies
- Microtubule and mitosis dynamics
- Advanced Breast Cancer Therapies
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Nutrition, Genetics, and Disease
- Cancer Risks and Factors
- Biomedical Ethics and Regulation
- Fibroblast Growth Factor Research
- Estrogen and related hormone effects
- Health disparities and outcomes
- Career Development and Diversity
- FOXO transcription factor regulation
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Skin and Cellular Biology Research
- Cellular Mechanics and Interactions
- Single-cell and spatial transcriptomics
City of Hope
2017-2022
Beckman Research Institute
2021
City Of Hope National Medical Center
2020
Duke University
2012-2015
North Carolina State University
2010-2013
Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor-positive (ER(+)) development, but receptor-negative (ER(-)) remains an unmet challenge due to gaps pathobiologic understanding. In this study, we used reverse-phase protein array identify activation Src kinase as early signaling alteration premalignant lesions women who did not respond...
Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry poor prognosis. Basal-like breast enriched for markers of cancer stem cells as well epithelial-mesenchymal transition (EMT). While EMT is generally thought to be important in the process metastasis, vivo evidence human disease remains rare. Here we report novel model triple-negative cancer, DKAT cell line, which was isolated from an aggressive, treatment-resistant that demonstrated...
Genomic imprinting is an inherited form of parent-of-origin specific epigenetic gene regulation that dysregulated by poor prenatal nutrition and environmental toxins. KCNK9 encodes for TASK3, a pH-regulated potassium channel membrane protein overexpressed in 40% breast cancer. However, amplification accounts increased expression <10% these cancers. Here, we showed imprinted tissue identified differentially methylated region (DMR) controlling its imprint status. Hypomethylation at the DMR,...
We have previously demonstrated that ras-mediated skin tumorigenesis depends on signaling pathways act preferentially through cyclin D1 and D2. Interestingly, the expression of D3 inhibits tumor development, an observation conflicts with oncogenic role D-type cyclins in mouse epidermis. Here, we show simultaneous up downregulation particular members family is a valuable approach to reduce tumorigenesis. developed K5D3/cyclin D1-/- compound mouse, which overexpresses but lacks skin. Similar...
There is a critical need for additional and effective comprehensive programs to increase the number of underrepresented minority students pursuing scientific careers. Science education high school often fragmented delivered with single-focused approaches, example traditional classroom lectures, hands-on-activities, or conducting research. The current paper examines biomedical research program that integrated teaching, study, mentoring from scientists in authentic settings. expectation would...
A subset of cells, termed side‑population (SP), which have the ability to efflux Hoeschst 33342, previously been demonstrated act as a potential method isolate stem cells. Numerous stem/progenitor cells localized in different regions mouse hair follicle (HF). The present study identified SP HF expressing ABCG2 transporter and MTS24 surface marker. These are restricted upper isthmus described progenitor Consistent with their characteristic, they elevated expression transporter, participates...
Abstract Background: Breast cancer (BC) prevention clinical trials (CTs) play a vital role in the progress of preventative measures and treatments for all races ethnicities. However, Northern European whites (NE/W) continue to be disproportionally enrolled (e.g., 93.5% were non-Hispanic white STAR trial), while minorities such as Asians, blacks, Latinas, Native Americans (NA) lag participation. Current studies suggest that are not approached frequently NE/W; however, they just willing...
Abstract Background: The current trend of increased survivability women with breast cancer has been linked to awareness, early detection and better treatment. In fact the American Cancer Society estimate that there are more than 2.5 million survivors living in America today. However trends these overall numbers expressed quiet differently African community. have a 77% five-year survival rate while rates for European at 90%. It is clear lack access plays role poor women. Other factors...
Abstract Background: There are more than 2.9 million breast cancer survivors in America today. However African American women have a 79% five-year survival while rates for European at 92%. While early detection increases the survivability of most cancer, standard mammogram fails to identify earlier stages some aggressive types cancer. Short-term risks increasingly being identified by Random Periareolar Fine Needle Aspiration (RPFNA). reproducibility this technique is no longer primary...
On the Cover: A complex interplay of cell death induction, aberrant fibroblast function, and tissue loss exists in incisional hernia (IH) fascia.Primary fibroblasts from non-IH fascia, shown stained for vinculin/phalloidin (green/red), display prominent streaks vinculin-positive focal adhesions that are widely distributed, whereas IH show more diffused staining confined to leading edges.Original magnification: ϫ400.
<div>Abstract<p>Preventing breast cancer will require the development of targeted strategies that can effectively block disease progression. Tamoxifen and aromatase inhibitors are effective in addressing estrogen receptor–positive (ER<sup>+</sup>) development, but receptor–negative (ER<sup>−</sup>) remains an unmet challenge due to gaps pathobiologic understanding. In this study, we used reverse-phase protein array identify activation Src kinase as early...