A5048386880- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Renal cell carcinoma treatment
- Renal and related cancers
- Urologic and reproductive health conditions
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Testicular diseases and treatments
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Male Reproductive Health Studies
- Reproductive Health and Technologies
- Cell death mechanisms and regulation
- Clinical practice guidelines implementation
- Cancer Cells and Metastasis
- Phagocytosis and Immune Regulation
- Cancer, Hypoxia, and Metabolism
- Hormonal and reproductive studies
- Cellular Mechanics and Interactions
- Sexual Differentiation and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Sperm and Testicular Function
- Genital Health and Disease
City of Hope
2019-2024
Vivantes Klinikum
2017-2024
Otto-von-Guericke University Magdeburg
2024
University of Bergen
2014-2024
Beckman Research Institute
2019-2024
BerGenBio (Norway)
2014-2024
City Of Hope National Medical Center
2021-2023
University Hospital Magdeburg
2022
Klinikum im Friedrichshain
2022
Klinikum Magdeburg
2022
Gemcitabine has limited clinical benefits in pancreatic ductal adenocarcinoma. The solvent-based traditional taxanes docetaxel and paclitaxel have not shown results superior to gemcitabine. Nab-paclitaxel, a water-soluble albumin-bound paclitaxel, may carry distribution properties into the tumor microenvironment efficacy multiple types. We evaluated nab-paclitaxel effects compared with gemcitabine or docetaxel. For adenocarcinoma cells AsPC-1, BxPC-3, MIA PaCa-2 Panc-1, IC 50 ranged from...
The extracellular matrix (ECM), a principal component of pancreatic ductal adenocarcinoma (PDA), is rich in fibrillar collagens that facilitate tumor cell survival and chemoresistance. Discoidin domain receptor 1 (DDR1) tyrosine kinase specifically binds has been implicated promoting proliferation, migration, adhesion, ECM remodeling, response to growth factors. We found collagen-induced activation DDR1 stimulated protumorigenic signaling through protein 2 (PYK2) pseudopodium-enriched...
Treatment in patients with seminoma who have residual or recurrent masses following chemotherapy is still a matter of debate. Surgical resection currently the most common recommendation for greater than 3 cm, resulting overtreatment up to 70% those affected. We analyzed accuracy preoperative positron emission tomography predicting viable tumor residuals seminoma.In prospective, multicenter trial computerized and FDG (2-(F-18)-fluoro-2-deoxy-D-glucose) were performed before surgical 20 had...
Abstract During aging in the human mammary gland, luminal epithelial cells lose lineage fidelity by expressing markers normally expressed myoepithelial cells. We hypothesize that loss of is a general manifestation epithelia are susceptible to cancer initiation. In present study, we show histologically normal breast tissue from younger women who cancer, as result harboring germline mutation BRCA1 , BRCA2 or PALB2 genes, exhibits hallmarks accelerated aging. These include proportionately...
Abstract Aggressive tumor progression, metastasis, and resistance to conventional therapies lead an extremely poor prognosis for pancreatic ductal adenocarcinoma (PDAC). Heparanase, enzyme expressed by multiple cell types, including cells in the microenvironment, has been implicated angiogenesis its expression correlates with decreased overall survival PDAC. We evaluated therapeutic potential of PG545, heparanase inhibitor, experimental PG545 inhibited proliferation, migration, colony...
We investigated the value of pretreatment prostate specific antigen density to predict Gleason score upgrading in light significant changes grading routine last 2 decades.Of 1,061 consecutive men who underwent radical prostatectomy between 1999 and 2004, 843 were eligible for study. Prostate was calculated a cutoff highest accuracy determined using ROC curve analysis. The predictive evaluated analysis based on predicted probabilities from logistic regression models.Prostate univariate (as...
Abstract Background Data on sequential therapy in patients with metastatic renal cell carcinoma (mRCC) and intrinsic resistance to receptor tyrosine kinase inhibitor (rTKI) treatment remains vague. Methods We retrospectively studied characteristics outcome of mRCC refractory first rTKI therapy. Results Thirty-five (male, 18; female, 11) primary (sunitinib, n = 28; sorafenib, 7) a median interval 2.4 months (1 - 4.6) were identified. In 22 patients, progressive disease (PD) was determined by...
Background and Purpose: Postoperative recovery of intestinal function, ability to ambulate, effective pain management are main features establish an fast-track surgery model. We investigated scores, ambulation rate, function in a cohort patients who were undergoing laparoscopic radical prostatectomy (LRP). Patients Methods: Fifty underwent LRP our institution randomized receive either conventional or postoperative care. was quantified by clinical signs motility. Ambulation data collected...
Background: The Polycomb group (PCG) proteins are epigenetic transcriptional repressors involved in the control of cellular proliferation and oncogenesis. This study aimed at examining whether mRNA tumor levels PCG family members BMI1, SUZ12, RING1, CBX7 relate to histopathological parameters urothelial carcinomas bladder they may provide prognostic information following resection. Methods: relative gene expression was analyzed by real-time RT-PCR tissue obtained from 93 patients with...
EZH2 increases the proliferation rate and apoptosis resistance of renal cell carcinoma lines. To date its clinical impact on outcome in patients with is not known. our knowledge this first study association expression histopathological features disease outcomes a large cohort who underwent surgery for carcinoma.Real-time reverse transcriptase-polymerase chain reaction was done to quantify malignant adjacent benign tissue from 119 clear carcinoma. Median followup 51 months....
Livin has recently been identified as a member of the inhibitor apoptosis family expressed in several types cancer but not most benign tissues. Expression levels livin were associated with prognosis various malignancies, expression and its prognostic relevance have evaluated renal cell carcinomas (RCC). In cohort 152 RCC patients, we analyzed relative splicing variants by real-time RT-PCR Western blot tumor adjacent normal tissue specimens. was detected 59 (38.8%) specimens none samples....
Literature regarding the influence of maternal age on pregnancy rates with male partners who have undergone vasectomy reversal is sparse. With tendency towards delayed childbirth, increased use as means family planning, and advances in reproductive techniques, this issue very important for patient counseling. The aim study to determine importance following reversal.A retrospective analysis was performed 212 patients underwent by a single surgeon (W.H.W.). Patient characteristics female...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? Over past decade, minimally invasive laparoscopic radical prostatectomy more recently robot‐assisted have been introduced proven equally effective compared with open surgery in terms mid‐term cancer control complication rates. Because long‐term data is lacking, still considered ‘gold standard’ by some authors, who argue that approaches to measure up excellent results surgery. This...
Gastric cancer is the second common cause of related death worldwide and lacks highly effective treatment for advanced disease. Nab-paclitaxel a novel microtubule-inhibitory cytotoxic agent that has not been tested in gastric as yet. In this study, human cell lines AGS, NCI-N87 SNU16 were studied. inhibited proliferation with an IC50 5 nM SNU16, 23 AGS 49 cells after 72-hour treatment, which was lower than oxaliplatin (1.05 μM to 1.51 μM) epirubicin (0.12 0.25 μM). increased expression...