A5021097418- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Hair Growth and Disorders
- RNA Research and Splicing
- Fatty Acid Research and Health
- Cardiovascular Disease and Adiposity
- MicroRNA in disease regulation
- Congenital heart defects research
- Physiological and biochemical adaptations
- Cancer-related molecular mechanisms research
- Zebrafish Biomedical Research Applications
- Hematological disorders and diagnostics
- Lipid metabolism and disorders
- Hippo pathway signaling and YAP/TAZ
- Inorganic and Organometallic Chemistry
- Advanced Polymer Synthesis and Characterization
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Pancreatic function and diabetes
- Dietary Effects on Health
- Synthesis and properties of polymers
- Genetics, Aging, and Longevity in Model Organisms
- Cholesterol and Lipid Metabolism
- Immune Cell Function and Interaction
- Muscle Physiology and Disorders
Yale University
2014-2025
Northwestern University
2010-2013
DePaul University
2010
Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these are not well understood. Mammary gland-associated white adipose (mgWAT) regresses of milk fat production during lactation expands subsequent involution milk-producing epithelial cells, providing one most marked physiological examples growth. We examined cellular functional implications adipocyte lipid dynamics mouse mammary gland (MG). Using vivo analysis...
The embryonic origin of distinct fat depots and the role for ontogeny in specifying functional differences among adipocyte lineages between within is unclear. Using a Cre/Lox-based strategy to track fate major mesodermal subcompartments mice we present evidence that <50% interscapular brown adipocytes are derived from progenitors central dermomyotome. Furthermore, demonstrate depot-specific spatially diverge as early gastrulation, perigonadal arise separate males females. Last, show...
White adipose tissue (WAT) is essential for maintaining metabolic function, especially during obesity. The intronic microRNAs miR-33a and miR-33b, located within the genes encoding sterol regulatory element-binding protein 2 (SREBP-2) SREBP-1, respectively, are transcribed in concert with their host function alongside them to regulate cholesterol, fatty acid, glucose metabolism. SREBP-1 highly expressed mature WAT plays a critical role promoting vitro adipocyte differentiation. It unknown...
Over the past 2 decades, incidence of childhood obesity has risen dramatically. This recent rise in is particularly concerning as adults who were obese during develop type II diabetes that intractable to current forms treatment compared with individuals adulthood. While mechanisms responsible for exacerbated diabetic phenotype associated not clear, it well known an important time period establishment normal white adipose tissue humans. association suggests exposure obesogenic stimuli...
Dietary fat composition has changed substantially during the obesity epidemic. As adipocyte hyperplasia is a major mechanism of adipose expansion, we aim to ascertain how dietary fats affect adipogenesis obesity. We employ an unbiased screen identify oleic acid (OA) as only fatty that induces obesogenic at physiologic levels and show plasma monounsaturated acids (MUFAs), which are mostly OA, associated with human OA stimulates in mouse precursor cells (APCs) by increasing AKT2 signaling,...
Vertebrate limb development involves a reciprocal feedback loop between mesenchyme and the overlying apical ectodermal ridge (AER). Several gene pathways participate in this loop, including Fgf signaling. In forelimb lateral plate mesenchyme, Tbx5 activates Fgf10 expression, which turn initiates maintains mesenchyme/AER signaling loop. Recent findings have revealed that transcriptional activity is regulated by dynamic nucleocytoplasmic shuttling interaction with Pdlim7, PDZ-LIM protein...
Novel copolymers of trisubstituted ethylene monomers, ring-substituted 2-phenyl-1,1-dicyanoethylenes, RC6H3CH˭C(CN)2 (where R is 2,3-(CH3O)2, 2,4-(CH3O)2, 2,5-(CH3O)2, 2,6-(CH3O)2, 3,4-(CH3O)2, and 3,5-(CH3O)2 4-fluorostyrene were prepared at equimolar monomer feed composition by solution copolymerization in the presence a radical initiator (ABCN) 70°C. The was calculated from nitrogen analysis, structures analyzed IR, 1H 13C-NMR. order relative reactivity (1/r 1) for monomers...