A5061934660- Dermatology and Skin Diseases
- Circadian rhythm and melatonin
- Wound Healing and Treatments
- Ion Channels and Receptors
- Herbal Medicine Research Studies
- Skin and Cellular Biology Research
- Skin Protection and Aging
- Mesenchymal stem cell research
- Poxvirus research and outbreaks
- Tendon Structure and Treatment
- Pressure Ulcer Prevention and Management
- Body Contouring and Surgery
- Oral Health Pathology and Treatment
- Nuclear Structure and Function
- Antimicrobial Peptides and Activities
- Wnt/β-catenin signaling in development and cancer
- Herpesvirus Infections and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Ubiquitin and proteasome pathways
- Fatty Acid Research and Health
- Fibroblast Growth Factor Research
- Adipose Tissue and Metabolism
- Lymphatic System and Diseases
University of North Carolina at Chapel Hill
2025
Duke University
2020-2023
Yale University
2018-2021
Myofibroblast diversity with injury and aging Fibroblasts deposit extracellular matrix (ECM) molecules to regulate tissue strength function. However, if too much ECM is deposited, fibrosis scarring results. Shook et al. examined cells during mouse skin wound healing, fibrosis, (see the Perspective by Willenborg Eming). They identified distinct subpopulations of myofibroblasts, including as adipocyte precursors (APs). In cellular ablation models, CD301b-expressing macrophages selectively...
Adipocytes undergo pronounced changes in size and behavior to support diverse tissue functions, but the mechanisms that control these are not well understood. Mammary gland-associated white adipose (mgWAT) regresses of milk fat production during lactation expands subsequent involution milk-producing epithelial cells, providing one most marked physiological examples growth. We examined cellular functional implications adipocyte lipid dynamics mouse mammary gland (MG). Using vivo analysis...
Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human expressed reduced levels of antiviral proteins (AVPs) circadian regulators, including Bmal1 Clock. Clock were found control rhythmic AVP expression in skin, such AVPs was diminished by disruption cell IL-27 signaling deletion Bmal1/Clock genes mouse as well siRNA-mediated knockdown CLOCK primary keratinocytes. treatment with...
Tissue fibrosis in many organs results from altered and excessive extracellular matrix (ECM) protein deposition 1 . Concomitant with ECM expansion, resident lipid-filled cells including mature adipocytes are lost human mouse 2-5 , yet the mechanisms that drive adipocyte lipid loss their contribution to tissue unknown. Here, we identify an early, fibro-protective role of lipolysis driven by Wnt signaling during onset. Using chemical genetic models skin fibrosis, show fibrotic stimuli induce...
ABSTRACT Aged skin is prone to viral infections, but the mechanisms responsible for this immunosenescent immune risk are unclear. We observed that aged murine and human expressed reduced antiviral proteins (AVPs) circadian regulators including Bmal1 Clock. Clock were found control rhythmic AVP expression in such circadian-control of AVPs was diminished by disruption cell interleukin 27 signaling deletion Bmal1/Clock genes mouse skins, as well siRNA-mediated knockdown CLOCK primary...
The skin serves as the interface between body and environment plays a fundamental role in innate antimicrobial host immunity. Antiviral proteins are part of defense system provide protection against viral pathogens. How breach barrier influences antiviral protein production remains largely unknown. Here, we identify characterize induction regulation following injury. Transcriptional phenotypic profiling cutaneous wounds revealed that injury induces high levels both mice humans, interleukin...