A5035316811- Fibroblast Growth Factor Research
- Wnt/β-catenin signaling in development and cancer
- Skin and Cellular Biology Research
- Body Contouring and Surgery
- Silk-based biomaterials and applications
- Nuclear Structure and Function
- Inflammatory Myopathies and Dermatomyositis
- Wound Healing and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nerve injury and regeneration
- Lymphatic System and Diseases
- Ubiquitin and proteasome pathways
- Skin Protection and Aging
- Systemic Sclerosis and Related Diseases
- Oral Health Pathology and Treatment
Yale University
2021-2025
Fibrosis is regulated by interactions between immune and mesenchymal cells. However, the capacity of cell types to modulate human fibrosis pathology poorly understood due lack a fully humanized model system. MISTRG6 mice were engineered homologous mouse/human gene replacement develop an system like humans when engrafted with hematopoietic stem cells (HSCs). We utilized scleroderma transplantation healthy or skin from patient pansclerotic morphea unmatched allogeneic HSC. identified that...
Tissue fibrosis in many organs results from altered and excessive extracellular matrix (ECM) protein deposition 1 . Concomitant with ECM expansion, resident lipid-filled cells including mature adipocytes are lost human mouse 2-5 , yet the mechanisms that drive adipocyte lipid loss their contribution to tissue unknown. Here, we identify an early, fibro-protective role of lipolysis driven by Wnt signaling during onset. Using chemical genetic models skin fibrosis, show fibrotic stimuli induce...