A5021875100- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Diversity and Impact of Dance
- Lymphatic System and Diseases
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Diabetic Foot Ulcer Assessment and Management
- Cancer, Stress, Anesthesia, and Immune Response
- Dermatology and Skin Diseases
- Nuclear Structure and Function
- Cardiomyopathy and Myosin Studies
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- RNA Research and Splicing
- Body Contouring and Surgery
- Skin and Cellular Biology Research
- Hair Growth and Disorders
- Infective Endocarditis Diagnosis and Management
- Muscle Physiology and Disorders
- Osteomyelitis and Bone Disorders Research
- Neurogenetic and Muscular Disorders Research
Yale University
2025
Cornell University
2022-2024
New York State College of Agriculture & Life Sciences
2022
University of Rochester
2017-2018
Abstract Perivascular adipocyte progenitor cells (APCs) can generate cold temperature-induced thermogenic beige adipocytes within white adipose tissue (WAT), an effect that could counteract excess fat mass and metabolic pathologies. Yet, the ability to declines with age, creating a key challenge for their therapeutic potential. Here we show ageing APCs overexpress platelet derived growth factor receptor beta ( Pdgfrβ ) prevent adipogenesis. We genetically deleting , in adult male mice,...
Obesity and associated type 2 diabetes (T2D) are important risk factors for infection following orthopedic implant surgery. Staphylococcus aureus, the most common pathogen in bone infections, adapts to multiple environments survive evade host immune responses. Whether adaptation of S. aureus unique environment obese/T2D accounts its increased virulence persistence this population is unknown. Thus, we assessed implant-associated osteomyelitis normal versus high-fat-diet mice found that was...
ABSTRACT Obese and type 2 diabetic (T2D) patients have a fivefold increased rate of infection following placement an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation, osteolysis, the effect obesity/T2D on these complicating factors has not been studied. To address this question, C57BL/6J mice were fed high fat diet (60% Kcal from fat) to induce obesity/T2D, or control (10% for 3 months, challenged transtibial pin...
Obese patients with type 2 diabetes (T2D) are at an increased risk of foot infection, impaired immune function believed to be a critical factor in the infectious process. In this study, we test hypothesis that humoral defects contribute exacerbated infection murine model obesity/T2D. C57BL/6J mice were rendered obese and T2D by high-fat diet for 3 mo compared controls receiving low-fat diet. Following injection Staphylococcus aureus into footpad, obese/T2D had greater swelling reduced S....
Sex steroids modulate the distribution of mammalian white adipose tissues. Moreover, WAT remodeling requires adipocyte progenitor cells. Nevertheless, sex-dependent mechanisms regulating progenitors remain undetermined. Here, we uncover Cxcr4 acting in a sexually dimorphic manner to affect pool proliferating cells leading restriction female fat mass. We find that deletion Pparγ-expressing results female, not male, lipodystrophy, which cannot be restored by high-fat diet consumption....
Abstract Beige adipocytes are induced by cold temperatures or β3-adrenergic receptor (Adrb3) agonists. They create heat through glucose and fatty acid (FA) oxidation, conferring metabolic benefits. The distinct shared mechanisms which these treatments induce beiging unknown. Here, we perform single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq) on adipose tissue from mice exposed to an Adrb3 agonist identify cellular accessibility dynamics during beiging. Both...
White adipose tissue (WAT) development and adult homeostasis rely on distinct adipocyte progenitor cells (APCs). While APCs are defined early during embryogenesis generate adipocytes after WAT organogenesis, the mechanisms underlying lineage determination preservation remain undefined. Here, we uncover a critical role for platelet-derived growth factor receptor beta (Pdgfrβ) in identifying APC lineage. Without Pdgfrβ, lose their adipogenic competency to incite fibrotic replacement...
Abstract Objective Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals. We aimed to determine if deleting Pdgfrβ mice could rejuvenate metabolically active by activating group 2 innate lymphoid cells (ILC2), and whether this effect counteract diet-induced obesity-associated fat decline. Methods employed gain-of-function loss-of-function mouse models targeting adipocyte progenitor (APCs). Our approach...
Platelet Derived Growth Factor Receptor Beta (Pdgfrβ) suppresses the formation of cold temperature-induced beige adipocytes in aged mammals. We aimed to determine if deleting Pdgfrβ mice could rejuvenate metabolically active by activating group 2 innate lymphoid cells (ILC2), and whether this effect counteract diet-induced obesity-associated fat decline.
Muscle cell fusion is critical for forming and maintaining multinucleated myotubes during skeletal muscle development regeneration. However, the molecular mechanisms directing cell-cell are not fully understood. Here, we identify platelet-derived growth factor receptor beta (PDGFRβ) signaling as a key modulator of myocyte in adult cells. Our findings demonstrate that genetic deletion
Abstract Beige adipocytes are induced by cold temperatures or β3-adrenergic receptor (Adrb3) agonists. They create heat through glucose and fatty acid (FA) oxidation, conferring metabolic benefits. The distinct shared mechanisms which these treatments induce beiging unknown. Here, we performed single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq) on adipose tissue from mice exposed to an Adrb3 agonist identify cellular accessibility dynamics during beiging. Both...
<title>Abstract</title> The sex-dependent distribution of mammalian white adipose tissue (WAT) drives the development obesity and its associated metabolic diseases. Here, we identify Cxcr4 acting in a sexual dimorphic manner to control pool proliferating adipocyte progenitor cells (APCs) direct female fat mass. We find that deleting within lineage results female, not male, lipodystrophy, which cannot be restored by high-fat diet consumption. also show deletion causes an APC shift at expense...