A5008527277- Breast Cancer Treatment Studies
- Bee Products Chemical Analysis
- Advanced Breast Cancer Therapies
- Cancer Risks and Factors
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Sirtuins and Resveratrol in Medicine
- Cancer Cells and Metastasis
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- BRCA gene mutations in cancer
- Healthcare and Venom Research
- Global Cancer Incidence and Screening
- Insect and Pesticide Research
- Virus-based gene therapy research
- Metabolism, Diabetes, and Cancer
- Phytoestrogen effects and research
- Cytokine Signaling Pathways and Interactions
- Cancer Research and Treatments
- Bone health and treatments
Rutgers, The State University of New Jersey
2018-2025
Johnson University
2019-2025
Rutgers Cancer Institute of New Jersey
2019-2024
Saint Barnabas Medical Center
2024
University of California, San Francisco
2019
University of Miami
2019
New York University
2010-2016
NYU Langone Health
2010-2016
Hiroshima University
2013
Columbia University
2001-2002
Cancer stem cells (CSC) are chemoresistant and implicated in tumor recurrence, metastasis high patient mortality; thus substances impairing CSC activity, could be invaluable as novel cancer therapeutics. We previously showed that CAPE (caffeic acid phenethyl ester), a component of propolis, honeybee product, inhibits growth MDA-MB-231 (MDA-231) cells, mdr gene expression, NF-κB, EGFR, VEGF. hypothesized also acts by interfering with CSC-mediated effects. isolated breast (bCSC) from MDA-231...
Abstract Introduction Rapamycin acts synergistically with platinum agents to induce apoptosis and inhibit proliferation in breast cancer cell lines. Combination of everolimus also known as RAD001 (oral mammalian target rapamycin (mTOR) inhibitor) carboplatin may have activity metastatic triple-negative (TNBC). Methods The primary objective this study was determine clinical benefit rate (CBR), that is (complete remission (CR) + partial (PR) stable disease (SD) lasting ≥6 months) the toxicity...
Obesity disproportionately affects Black women, who also have a higher risk of death after breast cancer diagnosis compared with women other racial/ethnic groups. However, few studies evaluated the association measures adiposity mortality among survivors.
LBA501 Background: I-SPY2.2 is a multicenter phase 2 platform sequential multiple assignment randomized trial (SMART) in the neoadjuvant breast cancer setting that evaluates novel experimental regimens as first sequence (Block A) followed by standard chemo/targeted therapies (Blocks B/C) if indicated. The goal to achieve pCR after targeted agents alone or with therapies, optimal therapy assigned based on tumor response predictive subtype (RPS). RPS incorporates expression-based immune, DNA...
Alternative remedies for cancer treatment is a multi-billion dollar industry. In particular, breast (BC) patients use alternative and natural more frequently than with other malignancies. Propolis an example of honeybee-produced naturopathic formulation, contents which differ by geographic location. It readily available, affordable, in safely since ancient times globally. Caffeic acid phenethyl ester (CAPE) major active component propolis thought to be responsible its varied properties,...
Abstract Background: The metabolomics approach using blood samples from epidemiological studies has the potential to elucidate pathways or uncover biomarkers for breast cancer (BC) outcomes. Therefore, understanding within-person reproducibility of metabolome and factors that influence metabolite levels over time in BC survivors are crucial, but these remain largely unknown. Methods: We estimated plasma metabolites 61 Black Women’s Circle Health Follow-Up Study. Samples were collected each...
Abstract Background Racial discrimination has been associated with decreased health‐related quality of life (QOL) in the general population; however, its impact on QOL cancer survivors is unclear. This study aims to examine how experiences (EOD) breast and whether these associations vary by individual‐ structural‐level factors. Methods The association EOD assessed at baseline (∼12 months post‐diagnosis) was Women’s Circle Health Follow‐up Study, a population‐based longitudinal cohort Black...
Abstract Background: Few studies have empirically tested the association of allostatic load (AL) with breast cancer clinicopathology. The aim this study was to examine AL, measured using relevant biomarkers recorded in medical records before diagnosis, unfavorable tumor clinicopathologic features among Black women. Methods: In a sample 409 women nonmetastatic who are enrolled Women's Circle Health Follow-Up Study, we estimated prediagnostic AL two measures: measure 1 [lipid...
Racial disparities in breast cancer (BC) survival arise from multilevel causes, which may exert influence at different stages of BC progression. Clarifying the importance genetic and social factors could help prioritize interventions.
Maintaining cardiovascular health (CVH) is critical for breast cancer (BC) survivors, particularly given the potential cardiotoxic effects of treatments. Poor CVH among Black BC survivors may be influenced by various area-level social determinants health, yet impact neighborhood archetypes in this population remains understudied. This study aimed to characterize where resided at diagnosis and evaluate their associations with CVH. We assessed 24 months post-diagnosis 713 participants...
Importance There are limited data about how lifestyle factors associated with breast cancer prognosis among Black or African American women because most of the evidence is based on studies White survivors. Objective To examine association prediagnostic cigarette smoking and alcohol consumption all-cause mortality cancer–specific in a cohort Design, Setting, Participants This population-based study included 1926 survivors who received diagnosis from June 6, 2005, to May 21, 2019, identified...
TGFβ promotes luminal differentiation of mammary stem cells by suppressing a BRCA1 -targeting microRNA.
Abstract Because the incidence of breast cancer increases decades after ionizing radiation exposure, aging has been implicated in evolution tumor microenvironment and progression. Here, we investigated radiation-induced carcinogenesis using a model which mammary glands 10-month-old BALB/c mice were transplanted with Trp53-null tissue 3 days exposure to low doses sparsely γ-radiation or densely particle radiation. Mammary transplants aged, irradiated hosts gave rise significantly more tumors...
Abstract Background The molecular mechanisms underlying the association between increased adiposity and aggressive breast cancer phenotypes remain unclear, but likely involve adipokines, leptin (LEP) adiponectin (ADIPOQ), their receptors (LEPR, ADIPOR1, ADIPOR2). Methods We used immunohistochemistry (IHC) to assess LEP, LEPR, ADIPOQ, ADIPOR2 expression in tumor tissue microarrays among a sample of 720 women recently diagnosed with (540 whom self-identified as Black). scored IHC...