Immunotherapy has shown significant control of intracranial metastases in patients with melanoma. However, the association immunotherapy combined other cancer treatments and overall survival (OS) brain metastases, regardless primary tumor site, is unknown.To explore OS who received definitive surgery site.This comparative effectiveness study included 3112 adult National Cancer Database from 2010 to 2016 non-small cell lung cancer, breast melanoma, colorectal or kidney at time diagnosis site....

Differences in overall survival (OS) between pediatric and adult patients diagnosed with osteosarcoma are poorly understood. The objective of this study is to compare the OS osteosarcoma, identify prognostic factors associated OS, explore specifically using data gathered from National Cancer Database (NCDB). Patients > = 1 years old 2004 2017 were included study. Multivariable Cox regression analysis adjusted for gender, race, income, education, place living, health insurance status, year...

Aim: To investigate the association of time interval between neoadjuvant RT and surgery (RS-interval) with pathological complete response (pCR) overall survival (OS) rectal cancer patients. Methods: We used National Cancer Database reported Odds ratios (OR) Hazard ratios. Results: Patients an RS-interval 5–24 weeks were more likely to achieve pCR compared ≤4 weeks. 13–24 was associated a reduced OS only in patients who did not pCR. Conclusion: 5–8, 9–12, 13–16, 17–20, or 21–24 higher...

Importance There are limited data about how lifestyle factors associated with breast cancer prognosis among Black or African American women because most of the evidence is based on studies White survivors. Objective To examine association prediagnostic cigarette smoking and alcohol consumption all-cause mortality cancer–specific in a cohort Design, Setting, Participants This population-based study included 1926 survivors who received diagnosis from June 6, 2005, to May 21, 2019, identified...

Abstract Background Immunotherapy has become an essential part of cancer treatment after showing great efficacy in various malignancies. However, its effectiveness pancreatic ductal adenocarcinoma (PDAC), especially resectable cancer, not been studied. The primary objective this study is to compare the OS impact immunotherapy between PDAC patients who receive neoadjuvant and adjuvant immunotherapy. secondary investigate combination with chemotherapy chemoradiation by performing subset...

Abstract Background Cancer patients with brain metastases (BMs) require multidisciplinary care, and treatment facility may play a role. This study aimed to investigate the impact of receiving at academic centers on overall survival (OS) cancer regardless primary site. Methods retrospective analysis National Database (NCDB) included diagnosed non-small cell lung cancer, small-cell other types breast melanoma, colorectal kidney had time diagnosis. The data were extracted from de-identified...

Abstract Background: We investigated racial and ethnic disparities in treatment sequence [i.e., neoadjuvant chemotherapy (NACT) plus interval debulking surgery (IDS) versus primary (PDS) adjuvant chemotherapy] among patients with ovarian cancer its contribution to mortality. Methods: Study included 37,566 women ages ≥18 years, diagnosed stage III/IV from the National Cancer Database (2004–2017). Logistic regression was used compute ORs 95% confidence intervals (CI) for sequence. Cox...

Immunotherapy has shown great efficacy in many cancers, but its role pancreatic ductal adenocarcinoma (PDAC) remains unclear. The objective of this study was to investigate the impact immunotherapy on overall survival PDAC patients who did not receive definitive surgery primary tumor site using National Cancer Database (NCDB).Patients with were identified from NCDB. Cox proportional hazard models employed assess after adjusting for age at diagnosis, race, sex, place living, income,...

Background and purpose Stereotactic radiosurgery (SRS) fractionated stereotactic radiation therapy (SRT) are both treatments shown to be effective in treating brain metastases (BMs). However, it is unknown how these compare effectiveness safety cancer patients with BMs regardless of the primary cancer. The main objective this study investigate SRS SRT treatments’ associations overall survival (OS) diagnosed using National Cancer Database (NCDB). Materials methods Patients NCDB breast cancer,...

Background The treatment landscape for ovarian cancer has changed in recent years with the introduction of targeted therapies to treat patients advanced disease. We investigated patient demographic and clinical factors associated use as a part first-line cancer. Methods This study included diagnosed stage I–IV between 2012 2019 from National Cancer Database. Information on characteristics were collected described using frequency percent across receipt therapy. Logistic regression was used...

Abstract Background Immunotherapy has paved the way for new therapeutic opportunities in cancer but failed to show any efficacy Pancreatic Adenocarcinoma (PDAC), and its role remains unclear. The objective of this study is examine impact immunotherapy combination with chemotherapy, RT, chemoradiation on overall survival (OS) PDAC patients who received definitive surgery tumor using National Cancer Database (NCDB). Methods Patients pancreatic were diagnosed between 2004 2016 from NCDB...

Aim: To investigate the association between receiving treatment at academic centers and overall survival in pancreatic ductal adenocarcinoma patients who do not receive definitive surgery of tumor. Methods: Using National Cancer Database, were diagnosed with 2004 to 2016 identified. Results: Of 262,209 patients, 101,003 (38.5%) received centers. In multivariable Cox regression analysis, a nonacademic facility had significantly worse compared treated an center (hazard ratio: 1.279; 95% CI:...

Aim: To investigate the association of stereotactic radiation therapy (SRT) or whole-brain (WBRT) plus immunotherapy with overall survival (OS) cancer patients brain metastases (BMs) regardless primary cancer. Patients & methods: diagnosed BMs were identified from National Cancer Database. Results: A total 34,286 included. SRT was associated improved OS compared without (hazard ratio: 0.774; 95% CI: 0.687-0.872; p < 0.001), and WBRT 0.724; CI; 0.673-0.779; 0.001). Conclusion: SRT. in who had...

Background: Immunotherapy has shown excellent efficacy in various cancers. However, there is a lack of knowledge regarding the significant role immunotherapy patients with brain metastases (BMs). The objective this study was to investigate, using National Cancer Database, impact on overall survival (OS) BMs who did not receive definitive surgery primary tumor. Patients and Methods: diagnosed cancer non–small cell lung cancer, small other types breast melanoma, colorectal or renal had at time...

Synchronous brain metastases (SBMs) are a presentation of stage IV cancers with limited treatment options. This study examines the association between health insurance status and overall survival (OS) patients SBMs using National Cancer Database (NCBD).We queried NCDB for from 2010 to 2015. Included cases were seven primary cancers. Patients grouped based on their status. We assessed OS Cox proportional hazards model adjusted age at diagnosis, sex, race, education level, income residential...

Immunotherapy has been approved for stage III non-small cell lung cancer (NSCLC) as consolidation therapy after chemoradiation in patients whose disease does not progress chemoradiation. However, many do receive due to either the drugs' side effects or poor performance status. This study's objective is investigate association of immunotherapy combined with chemotherapy Radiotherapy (RT) overall survival (OS) NSCLC who Patients received RT without were identified from NCDB. The Cox...

Aim: To investigate the role of immunotherapy in overall survival (OS) gastrointestinal cancer patients who have liver metastases at time primary site diagnosis.Materials & methods: Survival outcome was compared between groups with and without immunotherapy.Results: Chemoimmunotherapy associated improved OS (hazard ratio [HR] 0.768; 95% CI 0.739-0.800; p < 0.001) chemotherapy alone. Radiotherapy to plus chemoimmunotherapy also (HR 0.796; 0.705-0.898; chemoradiation. radiotherapy metastatic...

<title>Abstract</title> <bold>Background:</bold> Differences in overall survival (OS) between children and adult patients diagnosed with osteosarcoma are poorly understood. The objective of this study is to compare the OS pediatric osteosarcoma, identify prognostic factors associated OS, explore specifically using data gathered from National Cancer Database (NCDB). <bold>Methods:</bold> Patients &gt;=1 years old 2004 2017 were included study. Multivariable Cox regression analysis adjusted...

The association of immunotherapy in combination with radiation therapy (RT) or chemoradiation the overall survival (OS) patients diagnosed stage IV esophageal cancer (EC) is unknown. aim current study to explore OS advanced EC who received chemotherapy, RT, chemoradiation.

Background: Immunotherapy has shown great success in various malignancies. However, its efficacy pancreatic ductal adenocarcinoma (PDAC) remains a challenge, and the lack of understanding about appropriate timing immunotherapy with other standard-of-care cancer treatments may be one causes. The objective current study is to investigate impact chemotherapy radiation therapy (RT) on overall survival (OS) PDAC patients who did not receive surgical resection tumor. Materials Methods: Patients...

714 Background: Immunotherapy has revolutionized the treatment landscape of many malignancies, but its therapeutic role in pancreatic cancer (PC) remains unclear. The objective this study is to investigate impact immunotherapy on overall survival PC patients stratified by definitive surgery pancreas using National Cancer Database (NCDB). Methods: Patients with adenocarcinoma were identified from NCDB. Cox proportional hazard models employed assess after being and adjusted for age diagnosis,...

Abstract Background: Immunotherapy has paved the way for new therapeutic opportunities in cancer but failed to show any efficacy Pancreatic Adenocarcinoma (PDAC), and its role remains unclear. The objective of this study is examine impact immunotherapy combination with chemotherapy, RT, chemoradiation on overall survival (OS) PDAC patients who received definitive surgery tumor using National Cancer Database (NCDB). Methods: Patients pancreatic were diagnosed between 2004 2016 from NCDB...