A5055507874- Cancer Genomics and Diagnostics
- Prostate Cancer Treatment and Research
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Chemokine receptors and signaling
- Estrogen and related hormone effects
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Breast Cancer Treatment Studies
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Molecular Biology Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Cancer Risks and Factors
- Cancer, Lipids, and Metabolism
- Advanced Breast Cancer Therapies
- RNA Research and Splicing
- Economic and Financial Impacts of Cancer
- Cancer-related Molecular Pathways
Cornell University
2018-2025
Weill Cornell Medicine
2018-2025
Morehouse School of Medicine
2023-2025
Morehouse College
2025
Georgia Research Alliance
2025
Komfo Anokye Teaching Hospital
2018-2024
Presbyterian Hospital
2018-2024
New York Genome Center
2021-2023
Henry Ford Health System
2018-2022
University of Georgia
2005-2022
Women of sub-Saharan African descent have disproportionately higher incidence triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including prevalence basal-like quadruple-negative subtypes Americans (AA). However, previous investigations relied on self-reported race (SRR) primarily U.S. Due to heterogeneous genetic admixture biological consequences social determinants, the true association...
Abstract Precision medicine approaches to cancer treatment aim exploit genomic alterations that are specific individual patients tailor therapeutic strategies. Yet, some targetable genes and pathways essential for tumor cell viability even in the absence of direct alterations. In underrepresented populations, mutational landscape determinants response existing therapies poorly characterized because limited inclusion clinical trials studies. One way reveal is with genetic screens. Most...
To investigate subtype-specific risk of germline alleles associated with triple negative breast cancer (TNBC) in African ancestry populations.Breast (BC) mortality is higher American (AA) compared to White (WA) women; this disparity partly explained by 2-fold TNBC incidence.We used a surgically maintained biospecimen cohort 2884 BC cases. Subsets the total (760 AA; 962 WA; 910 West African/Ghanaian; 252 East African/Ethiopian) were analyzed for genotypes candidate alleles. A subset 417...
Abstract Crocin, a component of saffron spice, is known to have an anticancer activity. However, the targets crocin are not known. In this study, was found inhibit proliferation HCC70, HCC1806, HeLa and CCD1059sk cells by targeting microtubules. Crocin depolymerized both interphase mitotic microtubules different cancer cells, inhibited mitosis induced multipolar spindle formation in these cells. vitro , assembly pure tubulin as well microtubule-associated protein rich tubulin. Electron...
A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and recovery rate.
There is increasing evidence that Androgen Receptor (AR) expression has prognostic usefulness in Triple negative breast cancer (TNBC), where tumors lack AR are considered "Quadruple negative" Breast Cancers ("QNBC"). However, a comprehensive analysis of within all subtypes or stratified by race not been reported. We assessed mRNA 925 from The Cancer Genome Atlas (TCGA), and 136 2 confirmation sets. protein was determined immunohistochemistry 197 multi-institutional cohort, for total 1258...
Abstract Background: Tumor-specific immune response is an important aspect of disease prognosis and ultimately impacts treatment decisions for innovative immunotherapies. The atypical chemokine receptor 1 (ACKR1 or DARC) gene plays a pivotal role in regulation harbors several single-nucleotide variants (SNV) that are specific to sub-Saharan African ancestry. Methods: Using computational Cancer Genome Atlas (TCGA) analysis, case–control clinical cohort Luminex assays, CIBERSORT deconvolution,...
Poly (ADP-ribose) polymerase inhibitors (PARPi) are used for patients with BRCA1/2 mutations, but other mutations may benefit from PARPi treatment. Another mutation that is present in more cancers than to the TP53 gene. In 2D breast cancer cell lines, mutant p53 (mtp53) proteins tightly associate replicating DNA and (PARP) protein. Combination drug treatment alkylating agent temozolomide talazoparib kills mtp53 expressing grown lines. We evaluated sensitivity combination of plus lung...
miRNA expression in African American compared to Caucasian PCa patients has not been widely explored. Herein, we probed the profile of novel AA and CA derived prostate cancer cell lines. We found a unique signature associated with lines, independent tumor status. Evaluation most differentially expressed miRNAs showed that miR-132, miR-367b, miR-410, miR-152 were decreased more aggressive cells, this was reversed after treatment cells 5-aza-2'-deoxycytidine. Sequencing promoter confirmed it...
Integrated ferrohydrodynamic cell separation (iFCS) explores magnetization in biocompatible ferrofluids and enriches CTCs an antigen-independent size variation-inclusive manner.
African American (AA) prostate cancer associates with vitamin D3 deficiency, but D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses European (EA) and AA cell lines four clinical cohorts. Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) revealed that nonmalignant RC43N cells displayed the greatest dynamic content complex. Likewise, cells, Assay for Transposase-Accessible Chromatin using sequencing...
Abstract Background Insulin feedback is a critical mechanism responsible for the poor clinical efficacy of phosphatidylinositol 3-kinase (PI3K) inhibition in cancer, and hyperglycemia an independent factor associated with prognosis glioblastoma (GBM). We investigated combination anti-hyperglycemic therapy mouse model GBM evaluated association glycemic control trial data from patients GBM. Methods The effect regimens, metformin ketogenic diet, was PI3K patient-derived cells orthotopic model....
African American Men are 65% more likely to develop prostate cancer and twice as die of cancer, than Caucasian Males. The explanation for this glaring health disparity is still unknown; although a number different plausible factors have been offered including genetic susceptibility gene-environment interactions. We favor the hypothesis that altered gene expression plays major role in observed incidence mortality between To discover genes or pattern(s) unique Males explain males, we conducted...
// Honghe Wang 1 , Wei Liu 2 ShaNekkia Black Omari Turner Juliet M. Daniel 5 Windy Dean-Colomb 6 Qinghua P. He 3 Melissa Davis 4 Clayton Yates Department of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL, USA Laboratory Comparative Carcinogenesis, Frederick, MD, Chemical Engineering, Genetics, University Georgia, Athens, GA, Biology, McMaster Hamilton, ON, Canada Oncologic Hospital Clinics, Lafayette General Health, Lafayette, LA, Correspondence to: Yates, e-mail:...
More than 40% of patients with luminal breast cancer treated endocrine therapy agent tamoxifen demonstrate resistance. Emerging evidence suggests tumor initiating cells (TICs) and aberrant activation Src Akt signaling drive resistance relapse. We previously demonstrated that aryl hydrocarbon receptor ligand aminoflavone (AF) inhibits the expression TIC gene α6‐integrin disrupts mammospheres derived from tamoxifen‐sensitive cells. In current study, we hypothesize tamoxifen‐resistant (TamR)...
Triple negative breast cancers (TNBCs) are molecularly heterogeneous, and the link between their aggressiveness with African ancestry is not established. We investigated primary TNBCs for gene expression among self-reported race (SRR) groups of American (AA,
BackgroundLow-density neutrophils (LDN) are increased in several inflammatory diseases and may also play a role the low-grade chronic inflammation associated with obesity. Here we explored their obesity, determined gene signatures, assessed effect of bariatric surgery.MethodsWe compared number, function, expression profiles circulating LDN morbidly obese patients (MOP, n=27; body mass index (BMI) > 40 Kg/m2) normal-weight controls (NWC, n=20; BMI < 25 case-control study. Additionally,...
In this study, we used whole-exome sequencing of a cohort 45 advanced-stage, treatment-naïve Nigerian (NG) primary prostate cancer tumors and 11 unmatched nontumor tissues to compare genomic mutations with African American (AA) European (EA) The Cancer Genome Atlas (TCGA) cancer. NG samples were collected from six sites in central southwest Nigeria. After sequencing, processed using GATK best practices. BRCA1 (100%), BARD1 (45%), BRCA2 (27%), PMS2(18%) had germline alterations at least two...
Prostate cancer (PCa) is a leading cause of cancer-related deaths and driven by aberrant androgen receptor (AR) signalling. For this reason, deprivation therapies (ADTs) that suppress androgen-induced PCa progression either preventing biosynthesis or via AR signalling inhibition (ARSi) are common treatments. The N6-methyladenosine (m6A) RNA modification involved in regulating mRNA expression, translation, alternative splicing, through these mechanisms has been implicated development...