A5016826163- Prostate Cancer Treatment and Research
- Cancer-related gene regulation
- RNA modifications and cancer
- Estrogen and related hormone effects
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Natural Antidiabetic Agents Studies
- Sex and Gender in Healthcare
- Epigenetics and DNA Methylation
- Vitamin D Research Studies
- Vitamin C and Antioxidants Research
- Traditional and Medicinal Uses of Annonaceae
- Paraoxonase enzyme and polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Liver Disease Diagnosis and Treatment
- Diverse Scientific Research Studies
- Birth, Development, and Health
- Genetic factors in colorectal cancer
- Mycotoxins in Agriculture and Food
- Sexual Differentiation and Disorders
- Transgenic Plants and Applications
- Pomegranate: compositions and health benefits
- Selenium in Biological Systems
- Cholesterol and Lipid Metabolism
- Bioactive natural compounds
Covenant University
2014-2023
Aflatoxins are secondary metabolites of certain Aspergillus species, that contaminate staple foods, particularly in developing countries. Aflatoxin B1 (AFB1) is the most toxic and common major types aflatoxins. AFB1 hepatotoxic has been implicated increasing risk hepatocellular carcinoma (HCC). We have previously shown subacute exposure to for 7 days disrupts hepatic lipids; therefore, this study determined time-course effects acute aflatoxin on mitochondrial lipids oxidative stress. To...
African American (AA) prostate cancer associates with vitamin D3 deficiency, but D receptor (VDR) genomic actions have not been investigated in this context. We undertook VDR proteogenomic analyses European (EA) and AA cell lines four clinical cohorts. Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) revealed that nonmalignant RC43N cells displayed the greatest dynamic content complex. Likewise, cells, Assay for Transposase-Accessible Chromatin using sequencing...
Aflatoxins are toxic compounds produced by molds of the Aspergillus species that contaminate food primarily in tropical countries. The most aflatoxin, aflatoxin B1 (AFB1), is a major cause hepatocellular carcinoma (HCC) these In sub-Saharan Africa, contamination common, and perinatal AFB1 exposure has been linked to early onset HCC. Epigenetic programming, including changes DNA methylation, one mechanism which life exposures can lead adult disease. This study aims elucidate whether alters...
This study investigated the potential of stevioside to prevent oxidative DNA damage in liver and kidney type 2 diabetes mellitus (T2DM) using high fat-low streptozocin rat model. Rats were treated daily with 12.5, 25 50 mg/kg orally for 21 days. Levels biomarkers T2DM, lipid profile stress assayed spectrophotometrically. The ladder assay method was used assess fragmentation while computational analysis predict mechanisms antidiabetic properties stevioside. Stevioside significantly (p < 0.05)...
Context: Lipopolysaccharide (LPS) is a major trigger of septic shock resulting in multiple organ damage through excessive stimulation the host's immune cells release cytokines. Previous studies have shown that hesperidin has several beneficial properties against inflammation and oxidative stress.Objective: The influence on endotoxemia, endothelial dysfunction, inflammation, stress was investigated using murine model sepsis.Materials methods: Rats were pretreated for 15 d with three doses (50...
Medicinal plants have been documented over the years to play vital role in promoting human health. The study evaluated anti-inflammatory and anti-oxidant activities of different fractions isolated compound from Ricinodendron heudelotii leaves. leaves were extracted with ethanol further partitioned sequentially using petroleum ether, ethylacetate butanol. Bioassay–guided fractionation fraction was done repeated column chromatographic technique while structural elucidation pure carried out...
The generation of reactive oxygen species (ROS) plays an essential role in the pathogenesis several diseases. Its implication inflammation has suggested a possible link between oxidative stress and activation/release cytokines precancerous states. Recent observational studies have association vitamin D deficiency; hence, suggesting that could play This study examined antioxidant anti-inflammatory potentials diethylnitrosamine (DEN)-induced rats. Rats were divided into four experimental...
Hepatocellular carcinoma (HCC) is a common and leading cancer around the globe. This study investigated anticancer properties of extract Annona senegalensis in N-diethylnitrosamine (DEN) - induced hepatocellular male Wistar rats. Rats were simultaneously with combination 100 mg/kg b.wt DEN 0.5 mL/kg carbon tetrachloride (CCl4) intraperitoneally once week for three weeks row. Thereafter, animals treated 200 A. daily 21days. Analysis using gas chromatography-mass spectrometry (GC–MS) was...
ABSTRACT Background African American (AA) prostate cancer (PCa) appears uniquely sensitive to 1α,25(OH) 2 D 3 signaling, compared European (EA) PCa, but the extent and impact of vitamin receptor genomic functions remain poorly defined. Results A panel EA AA epithelial cells (EA: HPr1-AR, LNCaP, AA: RC43N, RC43T, RC77N, RC77T) were analyzed with RIME reveal cell-specific composition VDR- complex. -dependent ATAC-Seq revealed greatest on nucleosome positioning in RC43N gain nucleosome-free at...
This study evaluated the effects of quercetin and α‐lipoic acid on antioxidant status α‐Cypermethrin (α‐CYP) treated rats. 30 rats were randomly divided five experimental groups thus: (i) control group, (ii) α‐CYP alone (14.5 mg kg ‐1 body weight/day, p.o.), (iii) p.o.) (20 1h later, (iv) later (v) (vi) alone. After two weeks treatment, sacrificed blood collected by cardiac puncture organs excised for assay activities enzymes levels reduced glutathione (GSH) lipid peroxidation. induced a...
This study was designed to evaluate the hepatoprotective activity of seeds Hunteria umbellata (HU) on carbon tetrachloride (CCl4) induced rats. Rats groups 1 (normal control), 3 and 5 were not treated with CCl4 while rats 2 (negative 4 6 single dose (2 ml/kg) by intraperitoneal administration. Normal control group given distilled water, 50 mg/kg silymarin 500 HU. Treatment administered orally for 28 days sacrificed 29th day after an overnight fast. The weights taken before treatment. Blood...
This study was carried out to investigate the antioxidant properties of fresh juice ginger against aflatoxin‐exposure in rats. The preventive potential and capacity evaluated by assaying activities enzymes lipid peroxidation content some organs erythrocytes Twenty rats were randomly divided into four experimental groups thus: group 1 served as control, 2 received (2mL/Kg 10% juice)alone, 3 aflatoxins (3.65mg/kg body weight) alone while 4 pre‐treated with for 7days prior aflatoxin...
Naringin is one of the citrus‐derived flavonoids that have been reported for its antihyperglycemic, antihyperlipidemic and antioxidant properties. Although usefulness as nutraceutical in management diabetes has reported, there a dearth information on involvement lipid‐associated protein like paraoxonase antidiabetic activity. In order to investigate this, high fat‐low streptozocin model type 2 diabetic rats were treated daily with 50mg/kg, 100mg/kg 200mg/kg naringin orally 21days. The levels...
Oxidative stress and apoptosis have been reported to play major roles in the pathogenesis of Type 2 Diabetes Mellitus (T2DM) through insulin resistance β-cell dysfunction. Naringin is a citrus derived flavonoid that has for its antioxidant properties. Even though effects naringin T2DM related oxidative reported, varying dose concentration mechanism action involving far-fetched. This research studied at on apoptosis, biomarkers organ function high fat diet/low-streptozotocin-induced albino...
The nutraceutical role of dietary proteins and peptides is gaining considerable interest in the management cardiovascular disease like hypertension. In order to investigate contribution Sesamum indicum seed its antihypertensive properties was investigated, there protein sequences: 7S globulin (NCBI accession number, giǀ13183177), 2S albumin giǀ13183174) 11S giǀ13183172) were selected for BLAST, BIOPEP allergenicity analysis. BLAST gave following similarities: vs rice glutelin precursor...
This study evaluated the effect of quercetin on oxidative stress in a rat model L-arginine-induced acute pancreatitis. Thirty male rats were randomly divided into five experimental groups thus: control, L-arginine group (2g/Kg body weight, i.p), and other treated with 12.5mg/Kg 25mg/Kg weight 50mg/Kg an hour after L-argnine administration. Twenty four hours thereafter, sacrificed blood collected by cardiac puncture organs excised for assay plasma lipase α-amylase activities as well some...
Aframomum danielli is one of the African spices used in folklore medicine for management several diseases. This study identified phytochemical components present n‐hexane seed extract A. by gas chromatography‐mass spectrometry (GC‐MS) analysis and also evaluated anti‐cancer potential phytochemicals performing molecular docking against human Vascular Endothelial Growth Factor (VEGF) using Molegro Virtual Docker. The GC‐MS presence caryophyllene (RT: 18.479), humulene 19.189), 2‐butanone...