Tyrosine kinase (TK), vascular endothelial growth factor (VEGF), and matrix metalloproteinases (MMP) are important cancer therapeutic target proteins. Based on reported anti-cancer cytotoxic activities of Caesalpinia bonduc, this study isolated phytochemicals from young twigs leaves C bonduc identified the interaction between them proteins (TK, VEGF, MMP) in silico. AutoDock Vina, iGEMDOCK, analysis pharmacokinetic pharmacodynamic properties bioactives as molecules were performed. Seven...

Ficus exasperata has been used to treat ulcer, diabetes, fever, and a variety of stress-related disorders. Acetaminophen (APAP) overdose is the most common cause drug-induced acute liver injury. In this study, we evaluated hepatoprotective effect antioxidant capacity ethanolic extract F. (EFE) on acetaminophen-induced hepatotoxicity in albino rats. Rats were pretreated with EFE (150, 250, 500 mg/kg) thereafter received 250 mg/kg APA intraperitoneally (i.p.). The normal control group...

Genome-wide Association Studies (GWAS) are conducted to identify single nucleotide polymorphisms (variants) associated with a phenotype within specific population. These variants diseases have complex molecular aetiology which they cause the disease phenotype. The genotyping data generated from subjects of study is high dimensionality, challenge. problem that dataset has large number features and relatively smaller sample size. However, statistical testing standard approach being applied...

This research's primary focus was to evaluate the hepatoprotective potentials of Andrographis paniculata in carbon tetrachloride-induced hepatotoxicity Wistar rats.A total thirty-six (36) rats were used for this study.The animals shared equally into six (6) groups.Three groups (1, 3, and 5) served as control given distilled water (1 ml/kg), Silymarin (50 mg/kg), (500 mg/kg) group.The administration duration 28 days, after which they olive oil normal saline ml/kg).The other (2, 4, 6) treated...

The majority of liver-related illnesses are caused by occupational and domestic exposure to toxic chemicals like formaldehyde (FA), which is widely common in Africa the world at large. Hence, measures should be taken protect humans from its hazardous effects. This study, therefore, examines protective potential Ganoderma lucidum (100 mg/kg body weight) on formaldehyde-induced (40%) liver oxido-inflammation male rats. Male Wistar rats, 150-200 g, were allotted into four groups 10 animals as...

Background: Diabetes is associated with chronic hyperglycaemia, long-term damage, dysfunction, and organ failure. This study aims to evaluate the antidiabetic activity of twigs Andrographis paniculata its toxicological markers on Streptozotocin (STZ)-induced diabetic Albino rats. Methods: A total thirty rats were randomly divided into five groups six animals each. Non-diabetic treated distilled water as non-diabetic sham control group 1, while (group 2, 3, 4 5) 60 mg/kg bw STZ intravenous...

Abstract Background Diabetes, a global cause of mortality in developing countries is chronic disorder affecting the metabolism macromolecules and has been attributed to defective production action insulin characterized by persistent hyperglycemic properties. This harms organs body such as liver, kidney spleen. Medicinal plants Hunteria umbellate have shown possess hypoglycemic, antioxidative anti-diabetic properties owing high concentration active phytochemical constituents like flavonoids...

Abstract Rising prevalence of type 2 diabetes mellitus (T2DM) in sub-Saharan Africa has necessitated surveys antidiabetic medicinal plants. This study assessed the mechanism Terminalia catappa aqueous leaf extract (TCA) high fat/low dose streptozotocin-induced diabetic rats. T2DM was induced by a combination high-fat diet and low STZ (30 mg/kg bw) animals were administered with TCA (400 800 orally daily for 28 days. Biochemical parameters indices including renal function tests pancreatic...

Isoxazole and oxadiazole derivatives inhibiting 3-hydroxykynurenine transaminase (3HKT) are potential larvicidal candidates. This study aims to identify more suited inhibitors of Anopheles gambiae 3HKT (Ag3HKT) through molecular docking dynamics simulation. A total 958 compounds were docked against (PDB ID: 2CH2) using Autodock vina Autodock4. The top three identified hits subjected 300 ns simulation AMBER 18 ADMET analysis SWISSADME predictor ADMETSAR. Replacement alkyl attachment on C5...

Background Anthropometric measures have been widely used for body weight classification in humans. Waist circumference has advanced as a useful parameter measuring adiposity. This study evaluated the correlation between mass index (BMI) and waist examined their significance indicators of health status adults. Design Methods The subject included 489 healthy adults from Ota, Nigeria, aged 20 75 years, grouped into early adulthood (20-39 years), middle (40-59 years) (60 years above). Weight,...

Characterization and experimental modelling were employed for investigating prospects of Phyllanthus muellerianus as eco-friendly/sustainable material reducing concrete steel-reinforcement corrosion in industrial/microbial environment. Atomic Absorption Spectroscopy/Fourier Transform Infra Red Spectroscopy the inorganic organic constituent leaf, well total-corrosion effects leaf-extract admixture steel-reinforced requisitely analyzed interpreted. Results showed that is constituted non-toxic...

Heliotropium indicum is a plant of the Boraginaceae family reported to have multiple beneficial health effects, including analgesic, anti-malaria, anti-microbial, anti-tumor, anti-inflammatory, amongst others. 42 Male Wistar rats were used for this study. Group A served as control and received distilled water only. Groups B, C, D, E, F fed with extract Indicum in different concentrations. (500 mg/kg, 1000 1500 mg/kg 2000 3000 mg/kg) respectively. This study showed that contains...

Nonalcoholic fatty liver disease (NAFLD) has become notorious globally. Increasingly emerging evidence shows that NAFLD is strongly associated with inflammation, proinflammatory cytokines such as interleukin‐2 (IL‐2), interleukin‐6 (IL‐6), and tumour necrosis factor -α (TNF‐ α ) playing a vital role in its progression. In this work, an attempt was made to verify the anti‐inflammatory activity of Ruzu herbal bitters (RHB), antiobesity medicinal concoction, on induced by high‐fat diet (HFD)...

Context: One of the world’s most widespread and frequent liver diseases is non-alcoholic fatty disease (NAFLD). Aims: To evaluate preventives activities Ruzu herbal bitters (RHB), which an anti-obesity therapeutic concoction used widely in Nigeria on high–fat diet (HFD) induced NAFLD albino Wistar rats. Methods: A total number twenty-five rats were isolated divided equally into five groups. Group 1, normal control group was placed rat saline (1 mL/kg body weight daily) for twelve weeks. The...

Terminalia catappa leaves are used in managing both diabetes mellitus and its complications Southwest Nigeria. However, inhibitory activity on enzymes implicated is not very clear. This study investigated the vitro properties mode of inhibition T. leaf extracts associated with diabetes. The also identified some bioactive compounds as well their molecular interaction binding pocket these enzymes. Standard enzyme kinetics assays were performed to determine effects aqueous extract (TCA) ethanol...

Seven new compounds, including four lignans, (+)-(8S,8′S)-9,9′-dibenzoylsecoisolariciresinol (1), (+)-(8S*,8′R*)-4,4′-dimethyloxomatairesinol (2), (+)-(7S*,8R*,8′R*,9′S*)-9′-n-butoxytsugacetal (3), and pseudolarkaemin A (4), a pyronane glycoside, B (5), an ent-beyerene C (6), triterpene, 25-epi-pseudolarolide Q (7), along with 25 known compounds (8–32) were isolated from the twigs of Pseudolarix kaempferi. Their structures elucidated mainly by analysis their NMR MS data. Pseudolarolide acid...

The use of medicinal plants as an alternative mean treating various diseases has drawn the attention several researchers. desire to find lasting solutions epilepsy among humans increases every day. Thus, this work was aimed at investigating potential capacity studied phytochemicals in Alsophila spinulosa against human 4-aminobutyrate-aminotransferase well predict nonbonding interactions involved complexes. In work, ten compounds with biological activities were selected and using molecular...