A5054809613- Heavy Metal Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Trace Elements in Health
- Moringa oleifera research and applications
- Natural Antidiabetic Agents Studies
- SARS-CoV-2 and COVID-19 Research
- Nanoparticles: synthesis and applications
- COVID-19 Clinical Research Studies
- Computational Drug Discovery Methods
- Piperaceae Chemical and Biological Studies
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Diverse Scientific Research Studies
- Chemistry and Chemical Engineering
- Chromatography in Natural Products
- Occupational exposure and asthma
- Ginkgo biloba and Cashew Applications
- Analytical Chemistry and Chromatography
- Phytochemistry and Biological Activities
- Phytochemistry and biological activity of medicinal plants
- Ginger and Zingiberaceae research
- Immune cells in cancer
- Microplastics and Plastic Pollution
- Intellectual Capital and Performance Analysis
- Nanotechnology research and applications
University of Nigeria
2021-2025
University of Ibadan
2016-2018
Ficus exasperata has been used to treat ulcer, diabetes, fever, and a variety of stress-related disorders. Acetaminophen (APAP) overdose is the most common cause drug-induced acute liver injury. In this study, we evaluated hepatoprotective effect antioxidant capacity ethanolic extract F. (EFE) on acetaminophen-induced hepatotoxicity in albino rats. Rats were pretreated with EFE (150, 250, 500 mg/kg) thereafter received 250 mg/kg APA intraperitoneally (i.p.). The normal control group...
The pathophysiological processes involved in neurodegenerative diseases have not been clearly defined. Nevertheless, a significant aspect of the proof focuses directly on function several mechanisms inflammation. immune system is represented central nervous by microglial cell capable detecting harmful or foreign pathogens, and thus initiates self-activation neuro-inflammatory via phagocytosis cytokines release, to maintain cellular microenvironment. Then, cells can spawn an emphasis...
Cancer is a complex global health challenge that requires novel and holistic approaches to treatment prevention. Polyherbal medicines, composed of multiple plants with historical use in traditional medicine, have gained popularity due their safety, cost-effectiveness, accessibility. However, selecting the right determining optimal combinations for enhanced biological effects remains challenging. To address this, molecular docking study was conducted, targeting proteins implicated cancer...
Cadmium (Cd) has recently emerged as a major concern not only in environmental toxicology but also metabolic diseases such diabetes mellitus (DM) and its complications. Conflicting data aside, these studies have been examined clinical population undergoing management well possible modulation by the prominent antagonist of Cd zinc (Zn). This study relationship between cadmium levels, glycemic control renal pathology established type II diabetic patients with focus on populations exposed to...
Abstract Wnt/β‐catenin signaling pathway plays a role in cancer development, organogenesis, and embryogenesis. The abnormal activation promotes stem cell renewal, proliferation, differentiation. In the present study, molecular docking simulation ADMET studies were carried out on selected bioactive compounds search of β‐catenin protein inhibitors for drug discovery against cancer. Blind was performed using PyRx software Autodock Vina. (PDB ID: 1jdh) 313 (from PubChem database) with standard...
BACKGROUNDElectronic waste (e-waste) is known to contain thousands of toxic chemicals and metals, many which have identified endocrine disruption potentials even at low blood concentrations resulting from occupational environmental exposures. E-waste crude reprocessing in Nigeria massive a growing number Nigerians are occupationally exposed. The present study aimed determine changes gonadal hormone levels associated with e-waste Nigerian male workers. METHODSThis cross-sectional was carried...
The aim of the present study was to investigate effects Moringa oleifera seed oil against acetaminophen-induced liver injury.24 male Wistar albino rats were distributed into four treatment groups six animals each and lasted for ten days.Group1 Controls while group2 received acetaminophen dosage (1g/Kg body weight) only on tenth day.Group3 oral administration (2ml/kg also 10days prior being treated with (1g/kg day.Group4 administered days.Plasma activities marker enzymes ALT ALP significantly...
Green nanotechnology represents a burgeoning field that holds immense promise in the realm of nutraceuticals and pharmaceuticals. This comprehensive review explores multifaceted applications green nanotechnology, offering an extensive analysis its potential current achievements these vital sectors. The utilization plant extracts natural compounds as reducing stabilizing agents for nanoparticles is key focus this review. discussion encompasses various synthesis techniques, shedding light on...
Research is a deliberate and systematic inquiry or investigation to establish fact. could focus on any desired discipline like science, education, economy, administration, etc. Resources (e.g. humans, funds, equipment etc) are essential in research, especially impactful research. forms an part of development for interdisciplinary multidisciplinary application new technologies procedures. Progress comfort human beings due success research outcomes the society. In modern world, every sector,...
Abstract Background Hypertensive disorders of pregnancy including preexisting (or chronic) hypertension are the most common complication encountered during that contribute significantly to maternal and perinatal morbidity mortality. Brain natriuretic peptide (BNP) copeptin have been investigated as biomarkers in various hypertensive disorders, but studies their clinical value chronic pregnant women sparce. This study aimed assess levels BNP investigate correlation with blood pressure (BP)...
Mixed chemical toxicity including genotoxicity is currently a major concern in rapidly industrializing developing countries. Simple biomarkers remain constraint. Gamma-glutamyl-transpeptidase (GGT), precursor of glutathione, protects against genotoxic effects and may serve as marker for pre-neoplastic lesion. The objective the study was to determine possible relationship between GGT, uric acid angiogenic agent copper (Cu) mixed exposure. Sixty-six individuals occupationally exposed...
Background/Aim: Painful vaso-occlusive crisis (VOC) is the most frequent complication of sickle cell disease.The cause VOC believed to be ischemic tissue injury from obstruction blood flow by sickled erythrocytes.Sickling process leads hypoxia and acidosis; a cycle that eventually injury.The study was aimed at evaluating biochemical haematological changes in disease patients during steady state. Materials Methods:One hundred anaemia attending clinic University Nigeria Teaching Hospital,...
Objectives: There is increasing exposure to petrochemicals, including benzene, particularly in the low and medium-income countries. Benzene a component of many petrochemicals ubiquitous environmental pollutant. Phenol one its principal metabolites serves as biomarker benzene. The mechanism toxicity incompletely elucidated. Benzene’s interaction with key micronutrients; copper (Cu), iron (Fe), zinc (Zn) haemopoietic system has only been poorly explored, developing countries where their status...