A5012690658- Prostate Cancer Treatment and Research
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Acute Myeloid Leukemia Research
- Social and Educational Sciences
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cutaneous lymphoproliferative disorders research
- Retinoids in leukemia and cellular processes
- Adipose Tissue and Metabolism
- Angiogenesis and VEGF in Cancer
- T-cell and Retrovirus Studies
- Chemical Synthesis and Analysis
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical and Molecular Research
- PI3K/AKT/mTOR signaling in cancer
- RNA modifications and cancer
- Glycosylation and Glycoproteins Research
- Cell death mechanisms and regulation
- Lymphoma Diagnosis and Treatment
- Protease and Inhibitor Mechanisms
Umeå University
2013-2024
Malmö University
2007-2024
Southern University of Science and Technology
2023
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2023
Lund University
2013-2022
Heinrich Heine University Düsseldorf
2016
Klinik für Frauenheilkunde
2016
Düsseldorf University Hospital
2016
Clinical Research Management
2013-2015
One classical feature of cancer cells is their metabolic acquisition a highly glycolytic phenotype. Carbon monoxide (CO), one the products cytoprotective molecule heme oxygenase-1 (HO-1) in cells, has been implicated carcinogenesis and therapeutic resistance. However, functional contributions CO HO-1 to these processes are poorly defined. In human prostate cancers, we found that was nuclear localized malignant with low enzymatic activity moderately differentiated tumors correlating...
Abstract Interleukin‐6 (IL6) is a growth and survival factor in human prostate cancer (PCa) cells with aggressive phenotypes has been implicated the progression of hormone refractory PCas. In present study, we characterized IL6‐triggered PI3K/Akt MAPK/Erk signaling. We identified A‐type cyclin, cyclin A1 as an important downstream target PI3K/Akt. Treatment PI3K inhibitor or cotransfection vector expressing wild‐type PTEN decreased promoter activity. Cyclin activity its expression were...
The winter period is seldom included in the estimates of aquatic‐atmospheric carbon exchange. In this study we quantified flux dioxide (CO 2 ) and methane (CH 4 over 3 years from 12 small subarctic lakes. lakes accumulated consistent high amounts CO CH (56–97% as winter, resulting a during ice thaw. thaw increased with increasing mean depth lakes, while was surrounded by mires. quantitatively important to annual gas balances For nine 11 55% occurred three an apparent net uptake, including...
Significance Prostate cancer is the most common malignancy and third leading cancer-related cause of death among men Western world. Treatment options at advanced stages disease are scarce, better therapies in urgent need. In our study, we show that clinically relevant lipid kinase phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) plays an important role cell invasion survival by regulating PI3K/AKT/androgen receptor pathways. Elevated levels PIP5K1α contribute to proliferation, survival,...
Recurrent prostate cancer remains a major clinical challenge. The lysine specific demethylase‐1 (LSD1/KDM1A), together with the JmjC domain‐containing JMJD2A and JMJD2C proteins, have emerged as critical regulators of histone methylation. LSD1–JMJD2 complex functions transcriptional co‐regulator hormone activated androgen estrogen receptors at gene promoters. LSD1 also regulates DNA methylation p53 function. is overexpressed in numerous cancers including through an unknown mechanism. We...
Abstract Background Prostate cancer develops through malignant transformation of the prostate epithelium in a stepwise, mutation-driven process. Although activator protein-1 transcription factors such as JUN have been implicated potential oncogenic drivers, molecular programs contributing to progression are not fully understood. Methods We analyzed expression clinical samples across different stages and investigated its functional role Pten -deficient mouse model. performed histopathological...
Abstract Serine/arginine (SR) protein–specific kinase (SRPK), a family of cell cycle–regulated protein kinases, phosphorylate SR domain–containing proteins in nuclear speckles and mediate the pre-mRNA splicing. However, physiologic roles this event cycle are incompletely understood. Here, we show that SRPK2 binds phosphorylates acinus, an essential for RNA splicing, redistributes it from to nucleoplasm, resulting cyclin A1 but not A2 up-regulation. Acinus S422D, phosphorylation mimetic,...
Cyclin A1 is a cell cycle regulator that has been implicated in the progression of prostate cancer. Its role invasion and metastasis this disease not characterized.
Critical functions of the immune system are maintained by ability myeloid progenitors to differentiate and mature into macrophages. We hypothesized that cytoprotective gas molecule carbon monoxide (CO), generated endogenously heme oxygenases (HO), promotes differentiation functional Deletion HO-1, specifically in lineage (Lyz-Cre:Hmox1(flfl)), attenuated toward macrophages decreased expression macrophage markers, CD14 colony-stimulating factor receptor (MCSFR). showed HO-1 CO induced...
Abstract Bone metastasis is a leading cause of morbidity and mortality in prostate cancer. While cancer stem-like cells have been implicated as cell origin for metastasis, the pathways that enable metastatic development at distal sites remain largely unknown. In this study, we illuminate relevant to bone disease. We observed cyclin A1 (CCNA1) protein expression was relatively higher lesions lymph node, lung, bone/bone marrow. both primary tissues, also correlated with aromatase (CYP19A1),...
Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between proliferation differentiation, they maintain homeostasis normal tissues. Here, we screened homeobox mammary stem cells to establish role transformation breast Using a Genes PCR array, 83 cancer stem/progenitor isolated by flow cytometry. The candidate gene HOXC8 epigenetic regulation was studied DNA methylation miRNA analyses....
// Lise M. Lindahl 1 , Simon Fredholm 2 Claudine Joseph Boye Schnack Nielsen 3 Lars Jønson 4 Andreas Willerslev-Olsen Maria Gluud Edda Blümel David L. Petersen Nina Sibbesen Tengpeng Hu Claudia Nastasi Thorbjørn Krejsgaard Ditte Jæhger Jenny Persson 5 Nigel Mongan 6 Mariusz A. Wasik 7 Ivan V. Litvinov 8 Denis Sasseville 9 Sergei B. Koralov 10 Charlotte Bonefeld Carsten Geisler Anders Woetmann Elisabeth Ralfkiaer 11 Iversen Niels Odum Department of Dermatology, Aarhus...
Using Caenorhabditis elegans as an infection host model for Vibrio cholerae predator interactions, we discovered a bacterial cytotoxin, MakA, whose function virulence factor relies on secretion via the flagellum channel in proton motive force-dependent manner. The MakA protein is expressed from polycistronic makDCBA (motility-associated killing factor) operon. Bacteria expressing induced dramatic changes intestinal morphology leading to defecation defect, starvation and death C. elegans. Mak...
Cystatin C is believed to prevent tumor progression by inhibiting the activities of a family lysosomal cysteine proteases. However, little known about precise mechanism cystatin function in prostate cancer. In present study, we examined expression and its association with matrix metalloproteinases 2 (MMP2) androgen receptor (AR) tissue microarray comparing benign malignant specimens from 448 patients who underwent radical prostatectomy for localized was significantly lower cancer than...
// Emeli M. Nilsson 1,* , Kristian B. Laursen 2,* Jonathan Whitchurch 1,3 Andrew McWilliam 1 Niels Ødum 4 Jenny L. Persson 5 David Heery 3 Lorraine J. Gudas 2 and Nigel P. Mongan 1,2 Faculty of Medicine Health Sciences, School Veterinary Science, University Nottingham, United Kingdom Department Pharmacology, Weill Cornell Medical College, New York, NY, USA Pharmacy, Immunology Microbiology, Copenhagen, Denmark Clinical Research Center, Lund University, Malmö, Sweden * These authors have...