A5048058787- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Microbial Metabolism and Applications
- Protein Kinase Regulation and GTPase Signaling
- Bacterial Infections and Vaccines
- Antimicrobial Peptides and Activities
- Polyomavirus and related diseases
- Streptococcal Infections and Treatments
- Melanoma and MAPK Pathways
- Biochemical and Structural Characterization
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Peptidase Inhibition and Analysis
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Full-Duplex Wireless Communications
- RNA Research and Splicing
- Pneumonia and Respiratory Infections
- Plant Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Cellular Mechanics and Interactions
- NF-κB Signaling Pathways
- Immune Response and Inflammation
UiT The Arctic University of Norway
2016-2025
Centre for Arctic Gas Hydrate, Environment and Climate
2023-2025
University Hospital of North Norway
2023
Østfold University College
2020
Centre for Sustainable Energy
2004
Enterococcus faecium is a commensal but also bacteremia causing pathogen, which inherently resistant to several antimicrobials and has great ability acquire new traits. Bacterial membrane vesicles (MVs) are increasingly recognized as mode of cell-free communication way deliver virulence factors and/or antimicrobial resistance determinants. These features make MVs interesting research targets in on critical hospital pathogens. This study describes for the first time that E. strains produce...
Early recognition of pathogens by the innate immune system is crucial for bacterial clearance. Many pattern receptors (PRRs) such as Toll-like (TLRs) and (NOD)-like (NLRs) have been implicated in initial sensing components. The intracellular signaling cascades triggered these result transcriptional upregulation inflammatory pathways. Although this step elimination, it also associated with potential substantial immunopathology, which underscores need tight control responses. leading human...
Vitamin D induces the expression of antimicrobial peptides with activity against Staphylococcus aureus. Thus, we studied association between serum 25-hydroxyvitamin (25(OH)D) and S. aureus nasal colonization carriage. Nasal swabs, blood samples clinical data from 2,115 women 1,674 men, aged 30-87 years, were collected in Tromsø Staph Skin Study 2007-08, as part population-based sixth Study. Multivariate logistic regression analyses stratified by recognized risk factors for carriage: sex, age...
Staphylococcus aureus is known as a frequent colonizer of the skin and mucosa. Among bacterial factors involved in colonization are adhesins such microbial surface components recognizing adhesive matrix molecules (MSCRAMMs). Serine aspartate repeat containing protein D (SdrD) adhesion to human squamous cells isolated from nose. Here, we identify Desmoglein 1 (Dsg1) novel interaction partner for SdrD. Genetic deletion sdrD S. NCTC8325-4 through allelic replacement resulted decreased adherence...
The persistence of Staphylococcus aureus has been accredited to its ability escape immune response via host cell invasion. Despite the efficacy many antibiotics against S. aureus, high extracellular concentrations conventional required for bactericidal activity is limited by their low cellular accumulation and poor intracellular retention. While nanocarriers have received tremendous attention antibiotic delivery persistent pathogens, they suffer daunting challenges such as drug loading,...
Staphylococcus aureus produces membrane-derived vesicles (MVs), which share functional properties to outer membrane (OMVs). Atomic force microscopy (AFM) revealed that S. aureus-derived MVs are associated with the bacterial surface or released into surrounding environment depending on growth conditions. By using a comparative proteomic approach, total of 131 and 617 proteins were identified in isolated from grown Luria-Bertani (LB) Brain-Heart infusion (BHI) broth, respectively. Purified...
Increasing prevalence of infected and chronic wounds demands improved therapy options. In this work an electrospun nanofiber dressing with liposomes is suggested, focusing on the dressing's ability to support tissue regeneration infection control. Chloramphenicol (CAM) was chosen antibiotic, added nanofibers after first embedded in maintain a sustained drug release. Nanofibers spun from five different polymer blends were tested, where pectin polyethylene oxide (PEO) identified as most...
Signaling through Toll-like receptors (TLRs), crucial molecules in the induction of host defense responses, requires adaptor proteins that contain a Toll/interleukin-1 receptor (TIR) domain. The pathogen <i>Staphylococcus aureus</i> produces several innate immune-evasion interfere with host's immune response. A database search analysis suggested presence gene encoding homologue human TIR domain <i>S. MSSA476 which was named staphylococcal protein (TirS). Ectopic expression...
Colonization of the body is an important step in Staphylococcus aureus infection. S. colonizes skin and mucous membranes humans several animal species. One ecological niche anterior nares. More than 60% nose are found vestibulum nasi. Our aim was to describe localization nasal tissue from healthy carriers. Punch biopsies were taken nasi volunteers (S. carriers non−/intermittent carriers, n = 39) attending population-based Tromsø 6 study. The samples processed as frozen sections before...
ABSTRACT Staphylococcus aureus expresses a panel of cell wall-anchored adhesins, including proteins belonging to the microbial surface components recognizing adhesive matrix molecule (MSCRAMM) family, exemplified by serine-aspartate repeat protein D (SdrD), which serve key roles in colonization and infection. Deletion sdrD from S. subsp. strain NCTC8325-4 attenuated bacterial survival human whole blood ex vivo , was associated with increased killing neutrophils. Remarkably, SdrD able inhibit...
Using Caenorhabditis elegans as an infection host model for Vibrio cholerae predator interactions, we discovered a bacterial cytotoxin, MakA, whose function virulence factor relies on secretion via the flagellum channel in proton motive force-dependent manner. The MakA protein is expressed from polycistronic makDCBA (motility-associated killing factor) operon. Bacteria expressing induced dramatic changes intestinal morphology leading to defecation defect, starvation and death C. elegans. Mak...
Topical administration of drugs into the vagina can provide local therapy vaginal infections, preventing possible systemic side effects drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, thus it be utilized in improving localized by prolonging residence time a drug at site while acting as an antimicrobial synergy. Therefore, we aimed to explore potential chitosan, namely chitosan-coated liposomes hydrogel,...
Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infections and causes serious reproductive tract complications among women. The limitations existing oral antibiotics treatment antimicrobial resistance require alternative options. We are proposing, for first time, natural polyphenol resveratrol (RES) in an advanced delivery system comprising liposomes incorporated chitosan hydrogel, localized C. infection. Both free RES liposomes-in-hydrogel inhibited...
Burns and other skin injuries are growing concerns as well challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention eradication infectious biofilm-producing pathogens, while enhancing wound healing, urgently needed for timely infection-prone injuries. Treatment acute requires tailoring formulation assure both proper retention appropriate release incorporated antimicrobials. The challenge remains formulate antimicrobials with low water solubility,...
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