A5048016855- Antimicrobial agents and applications
- Wound Healing and Treatments
- Bacterial biofilms and quorum sensing
- Advancements in Transdermal Drug Delivery
- Nanocomposite Films for Food Packaging
- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Nail Diseases and Treatments
- Nanoparticles: synthesis and applications
- Pharmacology and Nanomedicine Research
- RNA Interference and Gene Delivery
- Lipid Membrane Structure and Behavior
- Curcumin's Biomedical Applications
- Dermatology and Skin Diseases
- Nanoparticle-Based Drug Delivery
UiT The Arctic University of Norway
2021-2024
Centre for Arctic Gas Hydrate, Environment and Climate
2024
Successful treatment of skin infections requires eradication biofilms found in up to 90 % all chronic wounds, causing delayed healing and increased morbidity. We hypothesized that chitosan hydrogel boosts the activity liposomally-associated membrane active antimicrobials (MAA) could potentially improve bacterial biofilm eradication. Therefore, liposomes (∼300 nm) bearing chlorhexidine (CHX; ∼50 μg/mg lipid) as a model MAA were incorporated into hydrogel. The novel CHX-liposomes-in-hydrogel...
Burns and other skin injuries are growing concerns as well challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention eradication infectious biofilm-producing pathogens, while enhancing wound healing, urgently needed for timely infection-prone injuries. Treatment acute requires tailoring formulation assure both proper retention appropriate release incorporated antimicrobials. The challenge remains formulate antimicrobials with low water solubility,...
The eradication of bacteria embedded in biofilms is among the most challenging obstacles management chronic wounds. These are found wounds; moreover, biofilm-embedded considerably less susceptible to conventional antimicrobial treatment than planktonic bacteria. Antimicrobial peptides and their mimics considered attractive candidates pursuit novel therapeutic options for wounds general bacterial eradication. However, some limitations linked these membrane-active antimicrobials making...
Infected chronic skin wounds and other infections are increasingly putting pressure on the health care providers patients. The is especially concerning due to rise of antimicrobial resistance biofilm-producing bacteria that further impair treatment success. Therefore, innovative strategies for wound healing bacterial eradication urgently needed; utilization materials with inherent biological properties could offer a potential solution. Chitosan one most frequently used polymers in delivery...
The main focus when considering treatment of non-healing and infected wounds is tied to the microbial, particularly bacterial, burden within wound bed. However, as fungal contributions in these microbial communities become more recognized, needs be broadened, remaining participants complex microbiome need addressed development new strategies. In this study, lecithin/chitosan nanoparticles loaded with clotrimazole were tailored eradicate one most abundant fungi environment, namely C....
Vaginal yeast infections, such as vulvovaginal candidiasis (VVC), affect nearly three out of four women worldwide. Re-occurrence is frequent and requires repeated treatments with oral, antifungal medications at high doses. Prolonged contribute to development resistant fungal strains the risk systemic adverse effects. drug delivery can overcome several disadvantages associated oral administration. However, current dosage forms, vaginal creams gels, are rapidly expelled from tract require...