A5009485093- Diabetes Treatment and Management
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Glioma Diagnosis and Treatment
- Diabetes Management and Research
- BRCA gene mutations in cancer
- Cancer Cells and Metastasis
- Genetics, Bioinformatics, and Biomedical Research
- Breast Lesions and Carcinomas
- MRI in cancer diagnosis
- Metabolism, Diabetes, and Cancer
- Lymphatic System and Diseases
- Radiomics and Machine Learning in Medical Imaging
- Diabetes and associated disorders
- Cutaneous Melanoma Detection and Management
- Cancer Immunotherapy and Biomarkers
- Advanced MRI Techniques and Applications
- Cellular Mechanics and Interactions
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Immune cells in cancer
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Ultrasound and Hyperthermia Applications
Henry Ford Health System
2010-2024
University of California, Los Angeles
1978-2024
UCLA Health
2024
Karolinska Institutet
2009-2023
UCLA Jonsson Comprehensive Cancer Center
2023
Henry Ford Hospital
1992-2022
State University of New York
2022
Stony Brook School
2022
University of Tampa
2022
Moffitt Cancer Center
2022
Women of sub-Saharan African descent have disproportionately higher incidence triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including prevalence basal-like quadruple-negative subtypes Americans (AA). However, previous investigations relied on self-reported race (SRR) primarily U.S. Due to heterogeneous genetic admixture biological consequences social determinants, the true association...
To investigate cardiovascular (CV) safety and event rates for dapagliflozin versus other glucose-lowering drugs (GLDs) in a real-world type 2 diabetes population after applying the main inclusion criteria outcomes from DECLARE-TIMI 58 study.
BACKGROUND: African-American women with breast cancer have poorer survival than European-American women. After adjustment for socioeconomic variables, differences diminish but do not disappear, possibly because of residual in health care access, biology, or behavior. This study compared and similar access. METHODS: We measured who are served by a large medical group metropolitan Detroit maintenance organization where screening, diagnosis, treatment, follow-up based on standard practices...
Abstract Background: Tumor-specific immune response is an important aspect of disease prognosis and ultimately impacts treatment decisions for innovative immunotherapies. The atypical chemokine receptor 1 (ACKR1 or DARC) gene plays a pivotal role in regulation harbors several single-nucleotide variants (SNV) that are specific to sub-Saharan African ancestry. Methods: Using computational Cancer Genome Atlas (TCGA) analysis, case–control clinical cohort Luminex assays, CIBERSORT deconvolution,...
OBJECTIVE Type 1 diabetes (T1D) and type 2 (T2D) increase risks of cardiovascular (CV) renal disease (CVRD) compared with diabetes-free populations. Direct comparisons between T1D T2D are scarce. We examined this by pooling full-population cohorts in Sweden Norway. RESEARCH DESIGN AND METHODS A total 59,331 patients 484,241 T2D, aged 18–84 years, were followed over a mean period 2.6 years from 31 December 2013. Patients identified nationwide prescribed drug hospital registries Norway Sweden....
In comparison with responses in recurrent glioblastoma (rGBM), the intracranial response of brain metastases (BrM) to immune checkpoint blockade (ICB) is less well studied. Here, we present an integrated single-cell RNA-Seq (scRNA-Seq) study 19 ICB-naive and 9 ICB-treated BrM samples from our own published data sets. We compared them previously scRNA-Seq rGBM found that ICB led more prominent T cell infiltration into than rGBM. These BrM-infiltrating cells exhibited a tumor-specific...
Objective To determine which mammographically guided breast biopsy technique is the most efficient in making a diagnosis women with suspicious mammograms. Summary Background Data Mammographically techniques include stereotactic 14-gauge core-needle (SC bx), 11-gauge suction-assisted core (Mammotome [Mbx]), coring excisional (Advanced Breast Biopsy Instrument [ABBI]), and wire-localized (WL bx). Controversy exists over best. Methods All patients undergoing any one of these methods 15-month...
Many consensus guidelines recommend routine surveillance to detect recurrent disease among cancer survivors. We compare care receipt guideline recommendations.Cohorts of patients aged 30 years or older diagnosed with breast, colorectal, endometrial, lung, prostate between 1990 and 1995 treated curative intent were identified (n = 100 per site). Receipt indications for examinations procedures abstracted from medical records as long 5 after treatment. Kaplan-Meier product estimates used...
Small molecules that induce non-apoptotic cell death are of fundamental mechanistic interest and may be useful to treat certain cancers. Here, we report tegavivint, a drug candidate undergoing human clinical trials, can activate unique mechanism in sarcomas other cancer cells. This lethal is distinct from ferroptosis, necroptosis pyroptosis requires the lipid metabolic enzyme trans -2,3-enoyl-CoA reductase (TECR). TECR canonically involved synthesis very long chain fatty acids but appears...
Abstract BACKGROUND The economics of breast cancer recurrence are poorly understood. For this retrospective cohort study, the authors evaluated economic burden by using data from a large Midwestern healthcare system. METHODS Women with Stage I or II (according to American Joint Commission on Cancer staging criteria) were identified tumor registry Henry Ford Health System. was estimated patient charges (adjusted 2003 U.S. dollars). RESULTS From 1996 2002, 1616 patients early identified,...
The objective of this work was to demonstrate that autoantibodies in breast cancer sera are not epiphenomena, and exhibit unique immunologic features resembling the rheumatic autoimmune diseases.We performed a comprehensive study on collection from women with or benign disease, undergoing annual screening mammography. All had suspicious mammography assessment underwent biopsy. We used indirect immunofluorescence, crithidia assay for anti-dsDNA antibodies, multiple ELISAs extractable nuclear...
PURPOSE: We designed a study to determine whether increases inp53protein in primary carcinomas of the colon or rectum correlate with overall survival. Mutations tumor suppressor genep53are detectable by immunocytochemical methods colorectal cancers because accumulation nuclearp53protein. METHODS: IgG1 monoclonal antibody humanp53protein (PAb 1801) was used detectp53in formalin-fixed, paraffin-embedded archival tumors resected from 84 patients limited bowel wall. A multivariate analysis...