A5040799512- Inorganic Chemistry and Materials
- Hydrogen Storage and Materials
- Magnetic and transport properties of perovskites and related materials
- Medical Imaging and Pathology Studies
- Ammonia Synthesis and Nitrogen Reduction
- X-ray Diffraction in Crystallography
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- MXene and MAX Phase Materials
- Cancer, Hypoxia, and Metabolism
- Nuclear Physics and Applications
- Heusler alloys: electronic and magnetic properties
- Cell Adhesion Molecules Research
- Iron-based superconductors research
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer Genomics and Diagnostics
- Chemical Synthesis and Characterization
- Radiopharmaceutical Chemistry and Applications
- Renal and related cancers
- Advanced NMR Techniques and Applications
- Single-cell and spatial transcriptomics
- Cardiac tumors and thrombi
UCLA Medical Center
2022-2025
Ronald Reagan UCLA Medical Center
2025
University of California, Los Angeles
2025
UCLA Health
2024
Star Technology and Research (United States)
2023
Vanderbilt University
2016-2022
Vanderbilt University Medical Center
2017-2018
University of Chicago
2010-2016
<h3>Background</h3> Immune checkpoint inhibitors, including antibodies against programmed death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 (CTLA-4), are being used with increasing frequency for the treatment of cancer. Immune-related adverse events (irAEs) colitis, dermatitis, pneumonitis well described, but less frequent now emerging larger numbers patients treated. Herein we describe incidence spectrum thrombocytopenia following immune inhibitor therapy two severe cases idiopathic...
By activating the transcription cofactors YAP and TAZ, receptor EphA2 mediates a metabolic switch to glutamine dependency in HER2 + breast cancers.
BackgroundApproximately 10% of patients with SCLC develop a paraneoplastic syndrome (PNS). Neurologic PNS are thought to improve prognosis, which we hypothesized is related increased tumor-infiltrating lymphocytes and immune recognition.MethodsWe queried 2,512,042 medical records from single institution identify who have without performed manual, retrospective chart review. We then multiplexed fluorescence immunohistochemistry automated quantitative analysis (AQUA Technology) on tumors...
In comparison with responses in recurrent glioblastoma (rGBM), the intracranial response of brain metastases (BrM) to immune checkpoint blockade (ICB) is less well studied. Here, we present an integrated single-cell RNA-Seq (scRNA-Seq) study 19 ICB-naive and 9 ICB-treated BrM samples from our own published data sets. We compared them previously scRNA-Seq rGBM found that ICB led more prominent T cell infiltration into than rGBM. These BrM-infiltrating cells exhibited a tumor-specific...
Abstract Background MRI-derived apparent diffusion coefficient (ADC) and contrast-enhancement (CE) may represent non-invasive biomarkers to evaluate microstructural tissue changes histopathological immune cell infiltration induced by checkpoint inhibitors (ICI). Methods 125 lesions across 93 patients were analyzed. ADC (reflecting water diffusivity) CE T1-subtraction maps blood-brain barrier permeability) tumor values used for bivariate histograms of CE, quantify voxel fractions belonging...
A tumor blood vessel is a key regulator of tissue perfusion, immune cell trafficking, cancer metastasis, and therapeutic responsiveness. mTORC1 signaling node downstream multiple angiogenic factors in the endothelium. However, inhibitors have limited efficacy most solid tumors, part due to inhibition function at high doses used oncology patients compensatory PI3K triggered by cells. Here we show that low-dose RAD001/everolimus, an inhibitor, selectively targets endothelial cells (ECs)...
<ns4:p><ns4:bold>Background:</ns4:bold> The conventional dogma of treating cancer by focusing on the elimination tumor cells has been recently refined to include consideration microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein involved in adhesion and migration, shown be suppressive context cell. However, its role not fully investigated. Here, we examine how ephrin-A1 deficiency affects growth metastasis murine model breast cancer.</ns4:p><ns4:p>...
<ns4:p><ns4:bold>Background:</ns4:bold> The conventional dogma of treating cancer by focusing on the elimination tumor cells has been recently refined to include consideration microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein involved in adhesion and migration, shown be suppressive context cell. However, its role not fully investigated. Here, we examine how ephrin-A1 deficiency affects growth metastasis murine model breast cancer.</ns4:p><ns4:p>...
Predicting response to ICI therapy among patients with renal cell carcinoma (RCC) has been uniquely challenging. We analyzed patient characteristics and clinical correlates from a retrospective single-site cohort of advanced RCC receiving anti-PD-1/PD-L1 monotherapy (N = 97), as well molecular parameters in subset patients, including multiplexed immunofluorescence (mIF), whole exome sequencing (WES), T receptor (TCR) sequencing, RNA (RNA-seq). Clinical factors such the development...
Novel characterization of patterns adverse events (AEs) kinase inhibitors (KIs) could reveal new insights on human molecular physiology and methods to improve the therapeutic index KIs. Incidence severity AEs for each 157 patients enrolled in sorafenib clinical trials were determined three clinically relevant treatment intervals: weeks 0-3, 3-7, after 7 weeks. The most common within patient co-occurrences mucositis with dermatologic events: hand-foot syndrome (HFS; odds ratio [OR] = 4.36; p...
Epithelioid angiosarcoma is an extremely rare subtype of cardiac that highly aggressive and associated with poor prognosis. Due to its nature, the epidemiology pathogenesis this disease are not well-known. Thus, effective diagnostic treatment modalities limited. Here, we report a case primary epithelioid in patient who was treated successfully surgical resection. A 45-year-old woman initially presented chronic systemic symptoms severe anemia subsequently developed new-onset atrial...
Abstract Nearly half of metastatic melanoma patients develop brain metastases (MBM). Local therapies like surgery and radiotherapy provide limited survival benefit. While targeted immune checkpoint inhibitors (ICI) improved outcomes in with asymptomatic MBM, the prognosis is still grim for majority patients. To decipher resistance mechanism to immunotherapy we integrated datasets from both single-cell RNAseq (scRNAseq) spatial transcriptomics (Visium). Our scRNAseq analysis 25 MBM (7 treated...
Motivation: Immune checkpoint inhibitors (ICIs) can promote immune cell infiltration and increase anti-tumoral response in brain metastases (BM). Imaging proxies of would facilitate ICI-response monitoring BM. Goal(s): To test whether the combined assessment diffusion contrast-enhancement MRI phenotypes provide insights into microscopic infiltration. Approach: We studied associations with histological ICI-treatment statusResults: Correlation analysis showed that high diffusivity pronounced...
Abstract Background: The brain metastatic niche has been historically difficult to study and thus poorly understood. Although metastases portend high morbidity mortality, increasing evidence shown that immune checkpoint blockade (ICB) can confer long-lasting responses in patients. How ICB remodels the tumor microenvironment is still relatively unknown. Here, we examine of resected a cohort 19 patients pre-operatively treated with without using single-cell methods. Methods: Tumor tissue was...