Kofi K. Gyan
A5042355944- Cancer Genomics and Diagnostics
- Genetics, Bioinformatics, and Biomedical Research
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Biotechnology and Related Fields
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Breast Cancer Treatment Studies
- Epigenetics and DNA Methylation
- Advances in Oncology and Radiotherapy
- CRISPR and Genetic Engineering
- Genetic factors in colorectal cancer
- Cancer-related Molecular Pathways
- PARP inhibition in cancer therapy
- Global Maternal and Child Health
- HER2/EGFR in Cancer Research
- Reproductive Health and Contraception
- Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Global Health and Surgery
- Immune cells in cancer
- Global Health Workforce Issues
- Molecular Biology Techniques and Applications
- Advanced Breast Cancer Therapies
- CAR-T cell therapy research
Cornell University
2018-2025
Weill Cornell Medicine
2018-2025
Komfo Anokye Teaching Hospital
2016-2024
Kwame Nkrumah University of Science and Technology
2016-2024
University of Michigan
2011-2018
Henry Ford Health System
2016-2018
NewYork–Presbyterian Hospital
2018
Henry Ford Hospital
2017
University of Ghana
2016
AstraZeneca (Brazil)
2016
Women of sub-Saharan African descent have disproportionately higher incidence triple-negative breast cancer (TNBC) and TNBC-specific mortality across all populations. Population studies show racial differences in TNBC biology, including prevalence basal-like quadruple-negative subtypes Americans (AA). However, previous investigations relied on self-reported race (SRR) primarily U.S. Due to heterogeneous genetic admixture biological consequences social determinants, the true association...
Abstract Precision medicine approaches to cancer treatment aim exploit genomic alterations that are specific individual patients tailor therapeutic strategies. Yet, some targetable genes and pathways essential for tumor cell viability even in the absence of direct alterations. In underrepresented populations, mutational landscape determinants response existing therapies poorly characterized because limited inclusion clinical trials studies. One way reveal is with genetic screens. Most...
Poly (ADP-ribose) polymerase inhibitors (PARPi) are used for patients with BRCA1/2 mutations, but other mutations may benefit from PARPi treatment. Another mutation that is present in more cancers than to the TP53 gene. In 2D breast cancer cell lines, mutant p53 (mtp53) proteins tightly associate replicating DNA and (PARP) protein. Combination drug treatment alkylating agent temozolomide talazoparib kills mtp53 expressing grown lines. We evaluated sensitivity combination of plus lung...
To investigate subtype-specific risk of germline alleles associated with triple negative breast cancer (TNBC) in African ancestry populations.Breast (BC) mortality is higher American (AA) compared to White (WA) women; this disparity partly explained by 2-fold TNBC incidence.We used a surgically maintained biospecimen cohort 2884 BC cases. Subsets the total (760 AA; 962 WA; 910 West African/Ghanaian; 252 East African/Ethiopian) were analyzed for genotypes candidate alleles. A subset 417...
The ability of many countries to achieve national health goals such as the Millennium Development Goals remains hindered by inadequate and poorly distributed personnel, including doctors. distribution doctors in Ghana is highly skewed, with a majority serving two major metropolitan areas (Accra Kumasi), numbers remote rural districts. Recent policies increasing worker salaries have reduced migration out Ghana, but made little difference within country. This qualitative study was undertaken...
Purpose Breast cancer, the most common cancer worldwide, is leading cause of mortality in Ghanaian women. Previous studies find women are diagnosed at a younger age and more advanced stages (III IV), have tumors with characteristics similar to African American We sought remedy gaps knowledge about breast survival Ghana its relation demographic biologic factors diagnosis assist control registration planning. Methods Individuals who care Komfo Anokye Teaching Hospital from 2009 2014 were...
Women with African ancestry in western, sub-Saharan Africa and the United States represent a population subset facing an increased risk of being diagnosed biologically aggressive phenotypes breast cancer that are negative for estrogen receptor, progesterone HER2/neu marker. These tumors commonly referred to as triple-negative cancer. Disparities incidence outcome related racial or ethnic identity motivated establishment International Breast Registry, on basis partnerships between Komfo...
<p>PDTOs breast cancer subtype analysis</p>
<p>IC50 values (µM) obtained for tested inhibitors in breast PDTO lines.</p>
<p>List of raw gRNA counts</p>
<p>List of primers and vectors used in this study.</p>
<p>List of inhibitors tested in HTDS alone or combination with gefitinib.</p>
<p>PDTO breast media composition.</p>
<p>Patient clinical information</p>
<div>Abstract<p>Precision medicine approaches to cancer treatment aim exploit genomic alterations that are specific individual patients tailor therapeutic strategies. Yet, some targetable genes and pathways essential for tumor cell viability even in the absence of direct alterations. In underrepresented populations, mutational landscape determinants response existing therapies poorly characterized because limited inclusion clinical trials studies. One way reveal is with genetic...
<p>Supplementary Figures 1-7</p>
Large-scale efforts to identify breast cancer (BC) risk alleles have historically taken place among women of European ancestry. Recently, there are new verify if these increase in African American (AA) as well. We investigated the effect previously reported AA and triple-negative (TNBC) our African-enriched International Center for Study Breast Cancer Subtypes (ICSBCS) cohort. Using case-control, case-series race-nested approaches, we report that Duffy-null allele (rs2814778) is associated...
Population-based incidence rates of breast cancers that are negative for estrogen receptor (ER), progesterone receptor, and human epidermal growth factor 2/ neu (triple-negative cancer [TNBC]) higher among African American (AA) compared with white (WA) women, TNBC prevalence is elevated selected populations patients. The extent to which risk related East versus West ancestry, whether these associations extend expression other biomarkers, uncertain.We used immunohistochemistry evaluate neu,...
Maternal mortality remains a huge problem in the developing world, especially Sub-Saharan Africa.1 According to World Health Organization, efforts intended decrease maternal deaths need recognize and address unsafe abortions as significant contributor high rates of found countries.2,3 In Africa, where are highly restricted, 680 women die per 100,000 abortions, compared with 0.2-1.2 developed countries, most legal.4.
Abstract Precision medicine approaches to cancer treatment aim exploit genomic alterations that are specific individual patients tailor therapy strategies. These usually revealed via next generation sequencing of the tumor tissue. Yet, it is clear some targetable genes and pathways essential for cell viability even in absence direct alterations. This especially important under-represented populations, whose mutational landscape determinants response existing therapies poorly characterized...
This study analyzes a survey conducted at gathering of clinicians who specialize in breast cancer sub-Saharan Africa to better understand what they need from international collaborators.
Poly (ADP-ribose) polymerase inhibitors (PARPi) are used for patients with