Shanpeng Li
A5101715817- Statistical Methods and Inference
- Glioma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Genetic Associations and Epidemiology
- Chronic Myeloid Leukemia Treatments
- BRCA gene mutations in cancer
- Acute Lymphoblastic Leukemia research
- Cardiovascular Function and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Acute Ischemic Stroke Management
- Cancer Genomics and Diagnostics
- Cardiac Health and Mental Health
- Blood Pressure and Hypertension Studies
- Machine Learning in Healthcare
- Acute Myeloid Leukemia Research
- Meta-analysis and systematic reviews
- Cardiovascular Disease and Adiposity
- Histone Deacetylase Inhibitors Research
- Lipoproteins and Cardiovascular Health
- Thyroid and Parathyroid Surgery
- Insurance, Mortality, Demography, Risk Management
- Cardiovascular Health and Risk Factors
- Intracerebral and Subarachnoid Hemorrhage Research
City Of Hope National Medical Center
2025
City of Hope
2024-2025
University of California, Los Angeles
2021-2025
Peking University
2023-2024
Beckman Research Institute
2024
University of Oxford
2014-2024
Cancer Research And Biostatistics
2023
UCLA Health
2021-2023
Central South University
2021
Applied Biomathematics (United States)
2021
Evidence is sparse and inconclusive on the association between long-term fine (≤2.5 μm) particulate matter (PM
Background— Despite the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in humans, there remains no evidence-based therapies for HFpEF. Endothelin-1 (ET-1) antagonists are a possibility because elevated ET-1 levels associated adverse cardiovascular effects, such as arterial and pulmonary vasoconstriction, impaired left ventricular (LV) relaxation, stimulation LV hypertrophy. hypertrophy is common phenotype HFpEF, particularly when hypertension. Methods...
Abstract Context The increased incidence of thyroid cancer globally over the past several decades is principally attributed to small, indolent papillary cancers. A possible concomitant increase in cancer-specific mortality remains debated. Objective changes and incidence-based were assessed using a large population-based cohort an 18-year period. Design & Patients retrospective analysis all cancers reported California Cancer Registry was performed (2000–2017). Age-adjusted rates analyzed...
In comparison with responses in recurrent glioblastoma (rGBM), the intracranial response of brain metastases (BrM) to immune checkpoint blockade (ICB) is less well studied. Here, we present an integrated single-cell RNA-Seq (scRNA-Seq) study 19 ICB-naive and 9 ICB-treated BrM samples from our own published data sets. We compared them previously scRNA-Seq rGBM found that ICB led more prominent T cell infiltration into than rGBM. These BrM-infiltrating cells exhibited a tumor-specific...
Molecular testing has improved risk stratification and increased nonoperative management for patients with indeterminate thyroid nodules, but data on the long-term outcomes of current molecular tests Afirma Gene Sequencing Classifier (GSC) Thyroseq v3 are limited.To determine rate delayed operation false negative GSC in Bethesda III IV nodules.Prospective follow-up a single center, randomized, clinical trial comparing performance diagnosis nodules at University California, Los Angeles...
Background— Despite the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in humans, there are no evidence-based therapies for HFpEF. Clinical studies suggest a relationship between obesity-associated dysfunctional adipose tissue (AT) and However, an apparent obesity paradox exists some HF populations higher body mass index. We sought to determine whether HFpEF exerted effects on AT investigated involved mechanisms. Methods Results— Mice underwent d -aldosterone...
In cancer research, leveraging patient-derived xenografts (PDXs) in pre-clinical experiments is a crucial approach for assessing innovative therapeutic strategies. Addressing the inherent variability treatment response among and within individual PDX lines essential. However, current literature lacks user-friendly statistical power analysis tool capable of concurrently determining required number animals per line group this context. paper, we present simulation-based R package sample size...
To demonstrate the potential value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) as a rapid, non-invasive metabolic imaging surrogate for pharmacological modulation EGFR signaling in EGFR-driven GBM, we synchronously conducted preclinical study using patient-derived orthotopic xenograft (PDOX) models and validated it phase II molecular recurrent GBM (rGBM) patients osimertinib. A PDOX mouse model was performed concurrently with an open-label, single-arm, single-center,...
Abstract Absolute risks of stroke are typically estimated using measurements cardiovascular disease risk factors recorded at a single visit. However, the comparative utility versus sequential factor for prediction is unclear. Risk were on three separate visits 13,753 individuals in prospective China Kadoorie Biobank. All participants stroke-free baseline (2004–2008), first resurvey (2008), and second (2013–2014), followed-up incident cases 3 years following resurvey. To reflect models...
Relapsed or refractory (R/R) acute myeloid leukemia (AML) with FMS-like tyrosine kinase 3 (FLT3) mutations remains a difficult and hard to treat entity. Gilteritinib is potent oral FLT-3 inhibitor that improves overall survival in R/R AML, but studies are limited combining gilteritinib hypomethylating agent venetoclax treatment backbone (HMA-VEN-GILT). Here we report our experience HMA-VEN-GILT for 22 FLT3 AML patients. yielded an ORR of 77.3% (17/22), CR 4.5% (1/22), CRi 13.6% (3/22), MLFS...
Despite the great burden of chronic respiratory diseases in China, few large multicentre, spirometry-based studies have examined its prevalence, rate underdiagnosis regionally or relevance socioeconomic and lifestyle factors.We analysed data from 512 891 adults China Kadoorie Biobank, recruited 10 diverse regions during 2004-2008. Air flow obstruction (AFO) was defined by lower limit normal criteria based on spirometry-measured lung function. The prevalence AFO region, age, status, body mass...
Little is known about the long-term risks of stroke and ischemic heart disease (IHD) in women who had a hysterectomy alone (HA) or with bilateral oophorectomy (HBO) for benign diseases, particularly China where burden cardiovascular diseases (CVD) high. We assessed mean levels risk factors relative IHD Chinese HA HBO.A total 302 510 women, aged 30 to 79 years were enrolled Kadoorie Biobank from 2004 2008 followed up 9.8 years. The analysis involved premenopausal without prior cancer at...
The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multiple BP with subsequent 5-year ICH risk, incremental value these over a single-point measurement in risk prediction.
In cancer research, leveraging patient-derived xenografts (PDXs) in pre-clinical experiments is a crucial approach for assessing innovative therapeutic strategies. Addressing the inherent variability treatment response among and within individual PDX lines essential. However, current literature lacks user-friendly statistical power analysis tool capable of concurrently determining required number animals per line group this context. paper, we present simulation-based R package sample size...
Summary Pegaspargase is a key drug for the treatment of younger adults with acute lymphoblastic leukaemia (ALL). Pegaspargase‐associated hepatotoxicity most common during induction, and its incidence increases age body mass index (BMI). We hypothesized that delayed administration pegaspargase induction associated lower risk while retaining efficacy. retrospectively reviewed 141 adult patients newly diagnosed ALL who received from November 2013 to February 2024. There were 78 (55.3%) early...
Semiparametric joint models of longitudinal and competing risk data are computationally costly, their current implementations do not scale well to massive biobank data. This paper identifies addresses some key computational barriers in a semiparametric model for survival By developing implementing customized linear scan algorithms, we reduce the complexities from <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"><a:mi>O</a:mi><a:mfenced open="("...
Both genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea health metrics (ICVHMs) offset association with incident HF remains unclear.
Abstract In biomedical studies it is common to collect data on multiple biomarkers during study follow‐up for dynamic prediction of a time‐to‐event clinical outcome. The are typically intermittently measured, missing at some event times, and may be subject high biological variations, which cannot readily used as time‐dependent covariates in standard model. Moreover, they can highly correlated if from the same pathway. To address these issues, we propose flexible joint model framework that...
In this paper, we describe an R package named JMcmprsk, for joint modelling of longitudinal and survival data with competing risks.The in its current version implements two models proposed to handle risks together continuous ordinal outcomes respectively (Elashoff et al., 2008;Li 2010).The corresponding implementations are further illustrated real examples.The also provides simulation functions simulate datasets or under the scenario, which provide useful tools validate evaluate new methods.