A5044488631- Cancer Cells and Metastasis
- Ubiquitin and proteasome pathways
- Plant biochemistry and biosynthesis
- Glioma Diagnosis and Treatment
- Psychiatric care and mental health services
- Cancer, Lipids, and Metabolism
- Healthcare Decision-Making and Restraints
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Erythropoietin and Anemia Treatment
- Cancer Research and Treatments
- Schizophrenia research and treatment
- NF-κB Signaling Pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Neurogenesis and neuroplasticity mechanisms
- Cell death mechanisms and regulation
- Electroconvulsive Therapy Studies
- 3D Printing in Biomedical Research
- PARP inhibition in cancer therapy
- Emergency and Acute Care Studies
- Cancer Genomics and Diagnostics
- Radiation Therapy and Dosimetry
- Psychosomatic Disorders and Their Treatments
- Mental Health and Psychiatry
University of California, Los Angeles
2016-2025
UCLA Jonsson Comprehensive Cancer Center
2012-2024
University of Colorado Denver
2013-2024
University of Colorado Cancer Center
2013-2024
Witten/Herdecke University
2022
University of Siegen
2022
Ruhr University Bochum
2022
Orthopädische Praxis
2015-2022
Technical University of Munich
2015-2020
Klinikum rechts der Isar
2015-2020
If cancer arises and is maintained by a small population of cancer-initiating cells within every tumor, understanding how these react to treatment will facilitate improvement in the future. Cancer-initiating can now be prospectively isolated from breast cell lines tumor samples propagated as mammospheres vitro under serum-free conditions.CD24(-/low)/CD44+ were MCF-7 MDA-MB-231 monolayer cultures mammospheres. Their response radiation was investigated assaying clonogenic survival measuring...
Gliomas contain a small number of treatment-resistant glioma stem cells (GSCs), and it is thought that tumor regrowth originates from GSCs, thus rendering GSCs an attractive target for novel treatment approaches. Cancer rely more on glycolysis than oxidative phosphorylation glucose metabolism, phenomenon used in 2-[ 18 F]fluoro-2-deoxy- d -glucose positron emission tomography imaging solid cancers, targeting metabolic pathways cancer has become topic considerable interest. However, if are...
Breast cancers are thought to be organized hierarchically with a small number of breast cancer stem cells (BCSCs) able regrow tumor while their progeny lack this ability. Recently, several groups reported enrichment for BCSCs when were subjected classic anticancer treatment. However, the underlying mechanisms leading incompletely understood. Using non‐BCSCs sorted from patient samples, we found that ionizing radiation reprogrammed differentiated into induced (iBCSCs). iBCSCs showed increased...
Glioblastoma (GBM) is the deadliest brain cancer in adults, and all patients succumb to tumor. While surgery followed by chemoradiotherapy delays disease progression, these treatments do not lead tumor control, targeted therapies or biologics have failed further improve survival. Utilizing a transient radiation-induced state of multipotency, we used adenylcyclase activator forskolin alter fate irradiated glioma cells. The effects combined treatment on neuronal marker expression, cell cycle...
There is increasing evidence that solid cancers contain cancer-initiating cells (CICs) are capable of regenerating a tumor has been surgically removed and/or treated with chemotherapy radiation therapy. Currently, cell surface markers, like CD133 or CD44, used to identify CICs in vitro; however, these markers cannot be and track vivo. The 26S proteasome the main regulator many processes within proliferating cell, its activity may altered depending on phenotype cell.Human glioma breast cancer...
Recent reports suggest that cancer control may worsen if erythropoietin is administered. We investigated whether receptor expression on cells correlate with this unexpected finding.Cancer tissue from patients advanced carcinoma of the head and neck (T3, T4, or nodal involvement) scheduled for radiotherapy was assayed retrospectively by immunohistochemistry. Patients were anemic randomized to receive epoetin beta (300 U/kg) placebo under double-blind conditions, given three times weekly...
Recent data indicate a hierarchical organization of many solid cancers, including breast cancer, with small number cancer initiating cells (CICs) that have the ability to self-renew and exhibit multi-lineage potency. We, others, demonstrated CICs in glioma are relatively resistant ionizing radiation if compared their non-tumorigenic counterparts. However, extent remaining self-renewing capacity after fractions is currently unknown. We hypothesized CICs, contrast counterparts, not only...
Abstract Background Glioblastoma is the most common brain tumor in adults. The mechanisms leading to glioblastoma are not well understood but animal studies support that inactivation of suppressor genes neural stem cells (NSC) required and sufficient induce glial cancers. This suggests NSC niches may harbor cancer (CSCs), Thus providing novel therapy targets. We hypothesize higher radiation doses these improve patient survival by eradicating CSCs. Methods 55 adult patients with Grade 3 or 4...
Innovation and progress in radiation oncology depend on discovery insights realized through research biology. Radiobiology has led to fundamental scientific insights, from the of stem/progenitor cells definition signal transduction pathways activated by ionizing that are now recognized as integral DNA damage response (DDR). Radiobiological discoveries guiding clinical trials test therapy combined with inhibitors DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated...
Cancer stem cells (CSCs) or tumor-initiating cells, similar to normal tissue rely on developmental pathways, such as the Notch pathway, maintain their cell state. One of regulators pathway is Musashi-1, a mRNA-binding protein. Musashi-1 promotes signaling by binding mRNA Numb, negative regulator signaling, thus preventing its translation. CSCs have also been shown downregulate 26S proteasome activity in several types solid tumors, making them resistant proteasome-inhibitors used anticancer...
There is considerable interest in defining the metabolic abnormalities of IDH mutant tumors to exploit for therapy. While most studies have attempted discern function by using cell lines transduced with exogenous enzyme, this study, we perform unbiased metabolomics discover differences between a cohort patient-derived IDH1 and wildtype gliomaspheres.Using both our own microarray TCGA datasets, performed KEGG analysis define pathways differentially enriched cells tumors. Liquid chromatography...
Experimental and clinical data suggest that solid cancers contain treatment-resistant cancer stem cells will impair treatment efficacy. The objective of this study was to investigate if head neck squamous cell carcinoma (HNSCC) also can be identified by low 26S proteasome activity their presence correlates outcome. Human HNSCC cells, engineered report lack based on accumulation a fluorescent fusion protein, were separated high (ZsGreen-cODCneg) or (ZsGreen-cODCpos) activity. Self-renewal...