A5074559844- Effects of Radiation Exposure
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Advanced Radiotherapy Techniques
- Carcinogens and Genotoxicity Assessment
- Virus-based gene therapy research
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Prostate Cancer Treatment and Research
- Spider Taxonomy and Behavior Studies
- Ultrasound and Hyperthermia Applications
- Head and Neck Cancer Studies
- Prostate Cancer Diagnosis and Treatment
- Cancer Research and Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer Cells and Metastasis
- Advances in Oncology and Radiotherapy
- Lung Cancer Treatments and Mutations
- Renal Diseases and Glomerulopathies
- Cancer Genomics and Diagnostics
- Sphingolipid Metabolism and Signaling
- Alzheimer's disease research and treatments
- Herpesvirus Infections and Treatments
- Lepidoptera: Biology and Taxonomy
University of Rochester Medical Center
2020-2025
University of Rochester
2020-2025
University of Miami
2016-2023
Sylvester Comprehensive Cancer Center
2016-2023
Onderwijsraad
2022
University of Miami Health System
2019
Beaumont Hospital, Royal Oak
2008-2017
Beaumont Health
2012-2017
Radiation Oncology Associates
2017
Oakland University
2012-2016
High-resolution measurements of the survival asynchronous Chinese hamster V79-379A cells in vitro after single doses X rays (0.01-10.0 Gy) and neutrons (0.02-3.0 were made using a computerized microscope for locating identifying (Palcic Jaggi, Int. J. Radiat. Biol. 50, 345-352, 1986). The X-ray response from 1 to 10 Gy showed good fit linear-quadratic (LQ) dose-survival model, but with below 0.6 Gy, an increased effectiveness was observed, cell prediction data above LQ model. effect per unit...
The anatomy, histology, and development of the nasal glands are described in several species birds belonging to seven orders. position glands, above orbits, course ducts, arrangement nerves blood-vessels very similar different species. There two ducts on each side, one duct opening niedian other lateral wall vestibule. In marine consist tubules, all sides which glandular diverticula radiate out. terrestrial reduced size, number especially diverticula. secretion consists a slimy mass...
Survival of HT29 cells was measured after irradiation with single doses X-rays (0.05-5 Gy) and neutrons (0.025-1.5 Gy), using a Dynamic Microscopic Imaging Processing Scanner (DMIPS) which individual can be accurately located in tissue culture flasks, their positions recorded, an appropriate incubation time the recorded revisited to allow scoring survivors. The response over X-ray dose range 2-5 Gy showed good fit Linear-Quadratic (LQ) model. For below 1 Gy, increased effectiveness observed...
Innovation and progress in radiation oncology depend on discovery insights realized through research biology. Radiobiology has led to fundamental scientific insights, from the of stem/progenitor cells definition signal transduction pathways activated by ionizing that are now recognized as integral DNA damage response (DDR). Radiobiological discoveries guiding clinical trials test therapy combined with inhibitors DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated...
Abstract Objective: We have shown previously that pretreatment with genistein potentiated cell killing induced by radiation in human PC-3 prostate carcinoma line vitro. tested this approach vivo using an orthotopic model of cells nude mice. Methods: Established tumors were pretreated p.o. at a dose 5 mg/d for 2 days followed tumor irradiation Gy photons. One day after radiation, was resumed and given every other 4 weeks. Results: Genistein combined caused significantly greater inhibition...
The survival of asynchronous and highly enriched G1-, S- G2-phase populations Chinese hamster V79 cells was measured after irradiation with 60Co gamma rays (0.1-10 Gy) using a precise flow cytometry-based clonogenic assay. high-dose responses demonstrated conventional relationship, being the most radiosensitive S-phase radioresistant. Below 1 Gy, distinct low-dose hyper-radiosensitivity (HRS) were observed for cell populations, no evidence HRS in G1- populations. Modeling supports conclusion...
Little is known about the mode of cell killing associated with low-dose hyper-radiosensitivity, radiation response that describes enhanced sensitivity cells to small doses ionizing radiation. Using a technique measures activation caspase 3, we have established relationship between apoptosis detected 24 h after exposure and hyper-radiosensitivity in four mammalian lines (T98G, U373, MR4 3.7 cells) two normal human lymphoblastoid lines. The existence clonogenic survival experiments was found...
The molecular mechanisms responsible for the development of proteinuria and glomerulosclerosis in radiation nephropathy remain largely unknown. Podocytes are increasingly recognized as key players pathogenesis primary secondary glomerular disorders. lipid-modulating enzyme sphingomyelin phosphodiesterase acid-like 3B (SMPDL3b) is a determinant podocyte injury known off target anti-CD20 antibody rituximab (RTX). current study investigates role sphingolipids radiation-induced podocytopathy....
The risk of recurrence following radiation therapy remains high for a significant number prostate cancer patients. development in vitro isogenic models radioresistance through exposure to fractionated is an increasingly used approach investigate the mechanisms cells and help guide improvements radiotherapy standards. We treated 22Rv1 with 2 Gy cumulative total dose 60 Gy. This process selected 22Rv1-cells increased clonogenic survival subsequent but sensitivity Docetaxel. RR-22Rv1 cell line...
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, despite optimized treatment options, median survival remains dismal. Contemporary evidence suggests disease recurrence results from expansion of a robustly radioresistant subset GBM progenitor cells, termed stem cells (GSCs). In this study, we utilized transmission electron microscopy to uncover ultrastructural effects on patient-derived GSC lines exposed supratherapeutic radiotherapy levels. Elevated...
Two visits to Western Samoa, totalling some four months, were devoted the intensive collecting of spiders. 90 species collected, which 32 are new and six records for islands though recorded elsewhere. Four males three females described belonging known previously only from other sex. Representatives eight families not found, one family being as new, Tamasesiidae. The total number now Samoa is 123, a much larger than that reported island groups in south-west Pacific. conclusion drawn knowledge...