A5004954855- Cancer Immunotherapy and Biomarkers
- Effects of Radiation Exposure
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Immune cells in cancer
- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- CAR-T cell therapy research
- T-cell and B-cell Immunology
- Nanoplatforms for cancer theranostics
- Prostate Cancer Diagnosis and Treatment
- interferon and immune responses
- Chemokine receptors and signaling
- Radiation Dose and Imaging
- Cancer, Stress, Anesthesia, and Immune Response
- Cell death mechanisms and regulation
- Genomics, phytochemicals, and oxidative stress
- Ultrasound and Hyperthermia Applications
- Animal Genetics and Reproduction
University of California, Los Angeles
2015-2024
APLA Health
2013-2023
UCLA Health
2020-2023
Olive View-UCLA Medical Center
2011-2019
University of Colorado Denver
2018
University of Colorado Cancer Center
2018
UCLA Jonsson Comprehensive Cancer Center
2018
Westwood Institute for Anxiety Disorders
2015
Molecular Oncology (United States)
2008
Northwood University
2005
Abstract Purpose: This study examined the feasibility, efficacy (abscopal effect), and immune effects of TGFβ blockade during radiotherapy in metastatic breast cancer patients. Experimental Design: Prospective randomized trial comparing two doses blocking antibody fresolimumab. Metastatic patients with at least three distinct sites whose tumor had progressed after one line therapy were to receive 1 or 10 mg/kg fresolimumab, every 3 weeks for five cycles, focal a site week (three 7.5 Gy),...
Abstract Purpose: A phase I study was conducted to determine safety, clinical efficacy, and antitumor immune responses in patients with advanced non–small cell lung carcinoma (NSCLC) following intratumoral administration of autologous dendritic cells (DC) transduced an adenoviral (Ad) vector expressing the CCL21 gene (Ad-CCL21-DC). We evaluated safety tumor antigen–specific situ vaccination (ClinicalTrials.gov: NCT01574222). Experimental Design: Sixteen stage IIIB/IV NSCLC subjects received...
Abstract Purpose: The goal of this study was to determine if radiation therapy (RT) human cancer enhances or diminishes tumor-specific T-cell reactivity. This is important immunotherapy be harnessed improve the outcome radiotherapy. Experimental Design: Lymphocytes were isolated from colorectal (CRC) patients before, during, and after presurgical chemoradiotherapy. Similar samples taken prostate receiving standard RT. level CD8+ T cells capable binding tetramers for tumor-associated antigen...
Innovation and progress in radiation oncology depend on discovery insights realized through research biology. Radiobiology has led to fundamental scientific insights, from the of stem/progenitor cells definition signal transduction pathways activated by ionizing that are now recognized as integral DNA damage response (DDR). Radiobiological discoveries guiding clinical trials test therapy combined with inhibitors DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated...
Radiation therapy (RT) can extend its influence in cancer beyond what be attributed to in-field cytotoxicity by modulating the immune system. While complex, these systemic effects help tip therapeutic balance favor of treatment success or failure. Engagement system is generally through recognition damage-associated molecules expressed released as a result tumor and normal tissue radiation damage. This has evolved discriminate pathological from physiological forms cell death signaling...
There is compelling evidence that lymphocytes are a recurring feature in radiation damaged normal tissues, but assessing their functional significance has proven difficult. Contradictory roles have been postulated both tissue pathogenesis and protection, although these not necessarily mutually exclusive as the immune system can display what may seem to be opposing faces at any one time. While exact role of T irradiated responses still obscure, accumulation after damage suggests they critical...
Glioblastoma stem cells (GSC) are a significant cell model for explaining brain tumor recurrence. However, mechanisms underlying their radiochemoresistance remain obscure. Here we show that most clonogenic in GSC cultures sensitive to radiation treatment (RT) with or without temozolomide (TMZ). Only few single survive and regain self-repopulating capacity. Cells re-populated from treatment-resistant clones contain more compared those grown treatment-sensitive clones, repeated cycles rapidly...
There is a significant need to find biomarkers of response radiotherapy and cetuximab in locally advanced head neck squamous cell carcinoma (HNSCC) that predict altered immunity, thereby enabling personalized treatment.To examine whether the Kirsten rat sarcoma viral oncogene homolog (KRAS)-variant, germline mutation microRNA-binding site KRAS, predictive biomarker immunity setting cisplatin treatment evaluate interaction KRAS-variant with p16 status blood-based transforming growth factor β1...
<h3>Background</h3> We previously reported the results of a multicentric prospective randomized trial chemo-refractory metastatic breast cancer patients testing efficacy two doses TGFβ blockade during radiotherapy. Despite lack objective responses to combination, who received higher dose blocking antibody fresolimumab had better overall survival when compared those assigned lower (hazard ratio 2.73, <i>p</i> = 0.039). They also demonstrated an improved peripheral blood mononuclear cell...
Local irradiation with a dose of around 0.5 Gy is an effective treatment acute necrotizing inflammations. The hypothesis that low doses X-rays modulate the oxidative burst in activated macrophages, which plays major role inflammatory process, was tested.Murine RAW 264.7 macrophages were stimulated LPS/gammaIFN, PMA or zymosan and measured using either DCFH-DA by reduction cytochrome-C. Radiation 0.3-10 given shortly before after stimulation.Low X-ray <1 significantly reduced whereas higher...
Acute radiation exposure of the thorax can lead to late serious, and even life-threatening, pulmonary cardiac damage. Sporadic in nature, complications tend be difficult predict, which prompted this investigation into identifying non-invasive, tissue-specific biomarkers for early detection injury. Levels circulating microRNA (miRNA) were measured C3H C57Bl/6 mice after whole irradiation at doses yielding approximately 70% mortality 120 or 180 days, respectively (LD70/120 180). Within first...