A5088072182- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- RNA modifications and cancer
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Urban Heat Island Mitigation
- Intracerebral and Subarachnoid Hemorrhage Research
- Neural dynamics and brain function
- Psychological Well-being and Life Satisfaction
- Viral Infectious Diseases and Gene Expression in Insects
- Urban Green Space and Health
- ECG Monitoring and Analysis
- Acute Kidney Injury Research
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Advanced Fluorescence Microscopy Techniques
- Birth, Development, and Health
- Cardiovascular Health and Risk Factors
- CCD and CMOS Imaging Sensors
- Neurosurgical Procedures and Complications
- Advanced Proteomics Techniques and Applications
First Affiliated Hospital of Xinxiang Medical University
2025
Harbin Medical University
2016-2024
Tsinghua University
1997-2022
Institute of Microbiology
2020-2022
Chinese Academy of Sciences
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2022
Peking University
2020
Institute of Microelectronics
2010-2012
Newcastle University
2011
Jiangxi Provincial Children's Hospital
2009
BackgroundStroke is a leading cause of death and disability worldwide. Despite considerable improvements in diagnosis treatment, little known about the short-term long-term prognosis after first stroke low-income middle-income countries, including China. We aimed to assess risk recurrent mortality for each major pathological types.MethodsThis population-based cohort study included adults aged 35–74 years without who were recruited China Kadoorie Biobank (CKB). A baseline survey was conducted...
This article discusses a cost-effective portable home unit for electrocardiogram (ECG) and blood pressure (BP) monitoring. Based on feedback from our previous work concerning PC-based ECG/BP telemonitoring system, the system described helps to overcome past problems by simplifying installation, operation, maintenance, reducing cost. The strategy methodology used in design development of as well results, are presented.
We present HealthGPT, a powerful Medical Large Vision-Language Model (Med-LVLM) that integrates medical visual comprehension and generation capabilities within unified autoregressive paradigm. Our bootstrapping philosophy is to progressively adapt heterogeneous knowledge pre-trained large language models (LLMs). This achieved through novel low-rank adaptation (H-LoRA) technique, which complemented by tailored hierarchical perception approach three-stage learning strategy. To effectively...
Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in occurrence and development It is unclear whether fatty acids play association between This study aims to investigate mediating role We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators outcomes. Summary data obtained from genome-wide insomnia, proposed failure were used this study. The overall includes...
Little is known about the long-term risks of stroke and ischemic heart disease (IHD) in women who had a hysterectomy alone (HA) or with bilateral oophorectomy (HBO) for benign diseases, particularly China where burden cardiovascular diseases (CVD) high. We assessed mean levels risk factors relative IHD Chinese HA HBO.A total 302 510 women, aged 30 to 79 years were enrolled Kadoorie Biobank from 2004 2008 followed up 9.8 years. The analysis involved premenopausal without prior cancer at...
Real-time multichannel neuronal signal recording has spawned broad applications in neuro-prostheses and neuro-rehabilitation. Detecting discriminating spikes from multiple spike trains real-time require significant computational efforts present major challenges for hardware design terms of area power consumption. This paper presents a Hebbian eigenfilter sorting algorithm, which principal components analysis (PCA) is conducted through learning. The eliminates the need computationally...
Background RNA structure is the crucial basis for function in various cellular processes. Over last decade, high throughput profiling (SP) experiments have brought enormous insight into secondary structure. Results In this review, we first provide an overview of approaches prediction, including free energy‐based algorithms and comparative sequence analysis. Then introduce SP technologies, databases to document data, pipelines/algorithms normalize interpret data. Computational frameworks that...
Both genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea health metrics (ICVHMs) offset association with incident HF remains unclear.
Abstract RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure in various Differential data different conditions reveal the structurally variable regions (SVRs), is important for understanding functions. Here, we propose DiffScan, a computational framework normalization and differential high...
L-Carnosine is a natural biologically active dipeptide with critical physiological functions, such as antioxidant, antiglycation, and cytoplasmic buffering properties. Direct enzymatic synthesis promising way for L-carnosine production. In this study, new aminopeptidase (gene_236976) synthetic activity toward was identified by metagenome mining approach from deep-sea sediment functionally expressed in Escherichia coli. The enzyme shared low identity of 14.3% reported dipeptidase (SmPepD)...
The emergence of multi-electrode array enables the study real-time neurophysiological activities across multiple regions brain. However, extracellular action potentials recorded on any electrode represent simultaneous electrical activity an unknown number neurons which present a critical challenge to accuracy interpretation and identification neural circuitry in subsequent analysis. In this paper, we principal component analysis approach utilizing Hebbian eigenfilter identify corresponding...
Abstract Background Principal component analysis (PCA) has been widely employed for automatic neuronal spike sorting. Calculating principal components (PCs) is computationally expensive, and requires complex numerical operations large memory resources. Substantial hardware resources are therefore needed implementations of PCA. General Hebbian algorithm (GHA) proposed calculating PCs spikes in our previous work, which eliminates the needs expensive covariance eigenvalue decomposition...
The correlation map of neurons emerges as an important mathematical framework for a spectrum applications including neural circuit modeling, neurologic disease bio-marking and neuroimaging. However, constructing is computationally expensive, especially when the number large. This paper proposes hardware design using hierarchical systolic arrays to calculate pairwise correlations between neurons. Through mapping efficient algorithm cross-correlation onto massively parallel structure, able...
Dynamic clamp emerges as an important apparatus to study the intrinsic neuronal properties through close-loop interactions between models and biological neurons. Modelling large-scale networks in software will result significant computational delay that becomes a bottleneck apply dynamic for more complicated systems. In this paper, we present real-time clamping system based on field programmable gate arrays (FPGAs) accelerate necessary computations. It also provides flexible platform...
To investigate the outcome of rapid lowering elevated blood pressure in patients with intracerebral hemorrhage and to understand its association clinical outcome.Between July 2014 June 2018, a total 1,500 diagnosed cerebral were randomized assessed for their neurological symptoms CT scan. (42%) received intensive treatment, while 1,645 (58%) assigned guideline-recommended therapy. The systolic these was measured every half hour during first day admission. intensive-treatment group further...
Rapid advances in multichannel neural signal recording technologies recent years have spawned broad applications neuro-prostheses and neuro-rehabilitation. The dramatic increase data bandwidth volume associated with requires a significant computational effort which presents major design challenges for brain-machine interface (BMI) system terms of power dissipation hardware area. In this paper, we present streaming method implementing real-time memory efficient processing hardware. This...
Abstract Background Existing evidence has identified that high-risk plaque (HRP) characterized by a thin-cap fibroatheroma and/or minimal lumen area ≤ 3.5 mm² were indicative of future cardiovascular events. Diffuse coronary artery disease also contributes to the poor prognosis. Purpose The present study aims assess prognostic value diffuse HRP in patients with acute myocardial infarction (AMI) using three-vessel optical coherence tomography (OCT). Methods A total 674 AMI who underwent OCT...
A 50-year-old female with a final diagnosis of Takotsubo cardiomyopathy (TCM) was reported. Episodes seizures, which were companied transient tombstoning ST elevation, recorded during treatment. This report on TCM elevation implies to clinicians that the ECG changes are great variability.
Rapid advances in multi-channel microelectrode neural recording technologies recent years have spawned broad applications implantable neuroprosthetic and rehabilitation systems. The dramatic increases data bandwidth volume associated with multichannel also come a large computational load which presents major design challenges for systems terms of power dissipation hardware area. In this paper, we present new methodology that utilizes Hebbian learning real-time signal processing. A...
A home electrocardiography (ECG) and blood pressure telemonitoring system for cardiac patients was installed in the Macau region. The monitoring centre established emergency unit at Government Hospital of Macau. first users were 10 cardiovascular selected by a physician. average age these 61 years (range 30–78). results three-month trial showed that easy to operate technically reliable. It found be helpful patients. most significant problem during electrical noise from ECG electrodes.
Background: Transglutaminase (TG) is an enzyme of the transferase family with cross-linking properties, which has been widely used in food industry. Traditionally, TG isolated from strains Streptomyces sp. However, development a facile and efficient production commercial always desirable. Purpose: In current study, we described route for food-grade strain bacteria, Bacillus subtilis. Method: Two strategies were employed extracellular S. ladakanum B. Sixteen signal peptides optimized to...
Abstract RNAs perform their function by forming specific structures, which can change across cellular conditions. Structure probing experiments combined with next generation sequencing technology have enabled transcriptome-wide analysis of RNA secondary structure in various Differential data different conditions reveal the structurally variable regions (SVRs), is important for understanding functions. Here, we propose DiffScan, a computational framework normalization and differential high...