A5100393895- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Liver physiology and pathology
- Inflammatory Biomarkers in Disease Prognosis
- Multiple Myeloma Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and biosynthesis
- Drug-Induced Hepatotoxicity and Protection
- RNA modifications and cancer
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Blood Pressure and Hypertension Studies
- MicroRNA in disease regulation
- Sepsis Diagnosis and Treatment
- Extracellular vesicles in disease
- Dialysis and Renal Disease Management
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Natural Language Processing Techniques
- Lymphoma Diagnosis and Treatment
- Reproductive biology and impacts on aquatic species
Tianjin Medical University
2023-2025
Tianjin Third Central Hospital
2023-2025
Capital Medical University
2024-2025
First Affiliated Hospital of Anhui Medical University
2018-2025
First Affiliated Hospital of Zhengzhou University
2024-2025
First Affiliated Hospital Zhejiang University
2025
Zhejiang University
2007-2025
Beijing Friendship Hospital
2025
Anhui Medical University
2018-2025
Tianjin Fire Research Institute
2025
Abstract Tumor metastasis is a hallmark of cancer. The communication between cancer-derived exosomes and stroma plays an irreplaceable role in facilitating pre-metastatic niche formation cancer metastasis. However, the mechanisms underlying exosome-mediated during colorectal (CRC) liver remain incompletely understood. Here we identified HSPC111 was leading upregulated gene hepatic stellate cells (HSCs) incubated with CRC cell-derived exosomes. In xenograft mouse model, exosomal facilitated...
Tertiary lymphoid structures (TLSs) have been proposed to assess the prognosis of patients with cancer. Here, we investigated prognostic value and relevant mechanisms TLSs in colorectal cancer liver metastases (CRCLM).603 CRCLM treated by surgical resection from three centers were included. The categorized according their anatomic subregions quantified, a TLS scoring system was established for intratumor region (T score) peritumor (P score). Differences relapse-free survival (RFS) overall...
Xiao Wang, Qin Liu, Tao Gui, Qi Zhang, Yicheng Zou, Xin Zhou, Jiacheng Ye, Yongxin Rui Zheng, Zexiong Pang, Qinzhuo Wu, Zhengyan Li, Chong Ruotian Ma, Zichu Fei, Ruijian Cai, Jun Zhao, Xingwu Hu, Zhiheng Yan, Yiding Tan, Yuan Qiyuan Bian, Zhihua Shan Qin, Bolin Zhu, Xiaoyu Xing, Jinlan Fu, Yue Minlong Peng, Xiaoqing Yaqian Zhongyu Wei, Xipeng Qiu, Xuanjing Huang. Proceedings of the 59th Annual Meeting Association for Computational Linguistics and 11th International Joint Conference on...
Abstract Distal cholangiocarcinoma (dCCA) is a highly lethal malignancy that accounts for approximately 40% of patients with primary cholangiocarcinoma. Remarkable cellular heterogeneity and perineural invasion (PNI) are two typical features dCCA. Deciphering the complex interplay between neoplastic neural cells crucial understanding mechanisms propelling PNI-positive dCCA progression. Herein, we conduct single-cell RNA sequencing on 24,715 from pairs tumors adjacent tissues, identifying...
Hemoglobin, albumin, lymphocyte and platelet (HALP) score is derived from the counts of hemoglobin, lymphocytes, platelets. It serves as a valuable tool for assessing both inflammation nutritional status in critically ill patients. However, there hasn't been specific study exploring role HALP Additionally, whether exhibits an incremental effect on Sequential Organ Failure Assessment (SOFA) remains unknown. In this study, we used Medical Information Mart Intensive Care (MIMIC-IV) version 2.2...
Telomere length plays important roles in maintaining genome stability and regulating cell replication death. Telomerase has functions not only to extend telomere but also repair DNA damage. Studies have shown that telomerase may increase cancer resistance DNA-damaging anticancer agents; tamoxifen suppress expression breast cells. This study aimed investigate the role of activity prognosis.qPCR qRT-PCR were used analyze expression, respectively, tumor samples 348 patients. Cox regression...
Abstract Ubiquitin A‐52 residue ribosomal protein fusion product 1 (UBA52) has a role in the occurrence and development of tumours. However, mechanism by which UBA52 regulates hepatocellular carcinoma (HCC) tumorigenesis progression remains poorly understood. By using Cell Counting Kit (CCK‐8), colony formation, wound healing Transwell assays, we assessed effects knockdown overexpression on proliferation migration HCC cells vitro. establishing subcutaneous metastatic tumour models nude mice,...
Abstract Background and Objectives Intraoperative bile duct injury is a significant complication in laparoscopic cholecystectomy (LC). Near‐infrared fluorescence cholangiography (NIFC) can reduce this complication. Therefore, determining the optimal indocyanine green (ICG) dosage for effective NIFC crucial. This study aimed to determine ICG NIFC. Methods was prospective, randomized, double‐blind clinical trial at single tertiary referral center, including 195 patients randomly assigned three...
BACKGROUND Proteasome inhibitors and mammalian target of rapamycin each have activity in various B‐cell malignancies affect distinct cellular pathways. Their combination has demonstrated synergy vitro mouse models. METHODS The authors conducted a single‐arm, phase 2 trial combined temsirolimus bortezomib patients with relapsed refractory non‐Hodgkin lymphoma (NHL) using dosing scheme that was previously tested multiple myeloma. received weekly on days 1, 8, 15, 22 35‐day cycle. RESULTS Of 39...
Neutrophil-to-lymphocyte ratio (NLR) is a promising prognostic marker for patients undergoing hepatectomy colorectal liver metastases (CRLM). However, its value in receiving neoadjuvant therapy (NAT) has not been sufficiently addressed. From 2013 to 2023, cohort of 692 with CRLM were enrolled five centers. Clinicopathological characteristics obtained from prospectively maintained multi-center database. The effect NLR (> 2 versus ≤ 2) on overall survival (OS) and recurrence-free was estimated...
An imbalance of excitatory and inhibitory signals in the brain has been proposed to be one main pathological features various diseases related hypothalamic-pituitary-adrenal axis (HPAA) dysfunction. Excessive glutamate release induces neuronal excitotoxicity, while glutamic acid decarboxylase (GAD) 67 promotes transformation excessive γ-aminobutyric (GABA). Our previous studies demonstrated that prenatal ethanol exposure (PEE) causes foetal over-exposure maternal corticosterone...
Identifying modifiable risk factors early on is essential to prevent major depressive disorder (MDD). This study systematically investigated the causal relationship between 19 and MDD. Single-nucleotide polymorphisms (SNPs) associated with potentially were screened via genome-wide association (GWAS) enrolling individuals of European descent. Summary-level data for MDD (59,851 cases 113,154 controls) extracted from UK Biobank. The inverse-variance-weighted (IVW) method was utilized as primary...
Glioma, an aggressive brain tumor, poses a challenge in understanding the mechanisms of treatment resistance, despite promising results from immunotherapy. We identified genes associated with immunotherapy resistance through analysis The Cancer Genome Atlas (TCGA), Chinese Glioma (CGGA), and Gene Expression Omnibus (GEO) databases. Subsequently, qRT-PCR western blot analyses were conducted to measure mRNA protein levels TBC1 Domain Family Member 1 (TBC1D1), respectively. Additionally, Set...
Background Impaired renal function (IRF) is associated with an elevated risk of major adverse events (MARE). However, the relationship between age-adapted estimated glomerular filtration rate (eGFR) criteria and in-hospital MARE has not been extensively studied in critically ill patients. Furthermore, impact eGFR trajectory changes on this patient population remains underexplored.
Previous studies support the causal effect of insomnia on heart failure. Fatty acid metabolism plays key roles in occurrence and development It is unclear whether fatty acids play association between This study aims to investigate mediating role We performed two-step, two-sample Mendelian randomization analysis by applying SNPs as genetic instruments for exposures, mediators outcomes. Summary data obtained from genome-wide insomnia, proposed failure were used this study. The overall includes...
Perioperative management and lung function recovery are vital for cancer patients. We conducted an open-label, single-center, noninferiority, randomized controlled trial in China to evaluate the efficacy of digital therapeutic (DTx)-assisted vs. multidisciplinary (MM) perioperative patients with cancer. From July 2022 June 2023, 186 minimally invasive surgery were randomized, 147 completed study. The participants randomly assigned a 1:1 ratio receive DTx-assisted (n = 72) or traditional MM...
Abstract The regulation of macrophages during inflammatory responses is a crucial process in alcoholic liver disease (ALD) and aberrant macrophage DNA methylation associated with inflammation. Our preliminary screening results the present study demonstrated zinc finger SWI2/SNF2 MuDR (SWIM)-domain containing 3 (ZSWIM3) were hypermethylated 5′ untranslated region (5′-UTR) region. ZSWIM3, novel finger-chelate domain SWIM, predicted to function DNA-binding protein-binding interactions. Its...
Salvianolic acid B (Sal B) has strong antioxidant and anti-fibrosis effects, which are related to the transforming growth factor β/Smad signaling pathway. However, how Sal affects this pathway phosphorylation (p-) of Smad2 at both COOH-terminal (pSmad2C) linker region (pSmad2L) unknown. The aims present study were investigate underlying mechanisms on acute chronic liver injury induced by CCl<sub>4</sub> H<sub>2</sub>O<sub>2</sub>, its effects p-Smad2C/L. In <em>in vivo</em> experiments,...
(1) Background: We aim to construct a machine learning (ML) algorithm predict the risk of distant metastasis (DM) T1 and T2gallbladder cancer (GBC); (2) Demographic clinical pathological data T2 GBC patients were extracted from National Institutes Health (NIH)’s Surveillance, Epidemiology, End Results (SEER) database between 2004 2015 develop seven ML models. Models evaluated based on accuracy, precision, recall rate, F1- score, area under receiver operating characteristic curve (AUC); (3)...
(1) Background: This study seeks to employ a machine learning (ML) algorithm forecast the risk of distant metastasis (DM) in patients with T1 and T2 gallbladder cancer (GBC); (2) Methods: Data diagnosed GBC was obtained from SEER, encompassing period 2004 2015, were utilized apply seven ML algorithms. These algorithms appraised by area under receiver operating characteristic curve (AUC) other metrics; (3) Results: involved 4371 total. Out these patients, 764 (17.4%) cases progressed develop...
Abstract Background This study investigated the correlation between tumor regression grade (TRG) score and Immunoscore, prognostic values of TRG a risk in colorectal cancer liver metastases (CRLMs) patients after neoadjuvant chemotherapy. Methods Patients undergoing chemotherapy from 2014 to 2019 were selected. Immunoscore evaluated 200 CRLMs. A combining score, clinical (CRS) was defined divided into low‐, medium‐, high‐risk groups. Differences relapse‐free survival (RFS) overall (OS)...