A5109310774- Stress Responses and Cortisol
- Birth, Development, and Health
- Neuroendocrine regulation and behavior
- Synthesis and bioactivity of alkaloids
- Liver Disease Diagnosis and Treatment
- Cancer Research and Treatments
- Probiotics and Fermented Foods
- Autophagy in Disease and Therapy
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Reproductive System and Pregnancy
- Carbon dioxide utilization in catalysis
- Drug-Induced Hepatotoxicity and Protection
- Cancer therapeutics and mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- Bioactive natural compounds
- Hippo pathway signaling and YAP/TAZ
- Synthesis and Biological Activity
- Selenium in Biological Systems
- Phytochemical Studies and Bioactivities
- Synthesis and Reactivity of Heterocycles
Lanzhou University
2022-2025
Second Affiliated Hospital of Soochow University
2019-2025
Soochow University
2019-2025
Yunnan Agricultural University
2025
Tianjin University
2024
Changchun Normal University
2023
Wuhan University
2015-2021
Shaanxi University of Technology
2021
Shanghai University of Traditional Chinese Medicine
2018-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2020
ABSTRACT Colorectal cancer (CRC) is a common accompanied by microbiome dysbiosis. Exploration of probiotics against oncogenic microorganisms promising for CRC treatment. Here, differential between and healthy control were analyzed. Antibacterial experiments, whole-genome sequencing, metabolic network reconstruction combined to reveal the anti- Fusobacterium nucleatum mechanism, which was verified co-culture assay mendelian randomization analysis. Sequencing results showed that F. enriched in...
Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) a natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by API against APAP-induced injury in mice, and explored potential mechanism. Cell viability assays mice were used to evaluate effects injury. Western blotting, immunofluorescence staining, RT-PCR, Transmission Electron Microscope carried out determine signalling pathways affected API. Analysis mouse serum levels...
Nonalcoholic fatty liver disease is associated with obesity and insulin resistance. Factors that regulate the disposal of hepatic triglycerides contribute to development steatosis. G0/G1 switch gene 2 (G0S2) a target peroxisome proliferator-activated receptors plays an important role in regulating lipolysis adipocytes. Therefore, we investigated whether G0S2 lipid metabolism. Adenovirus-mediated expression (Ad-G0S2) potently induced mice. The mass Ad-G0S2-infected mice was markedly increased...
Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) phenolic compound derived from natural products such as fruit vegetables. Our research investigated the protective mechanisms FST APAP-induced hepatic injury vitro vivo. Assessment mouse serum levels alanine/aspartate aminotransferases (ALT/AST), myeloperoxidase (MPO) activity, malondialdehyde (MDA), glutathione (GSH) reactive oxygen species (ROS) demonstrated...
The determination of allergenic proteins in Moringa oleifera leaves, which is the main components immune activity, has enabled development a more effective method for evaluating activity extracted leaves protein. In this study, extraction process protein was optimized based on single factor experiment. hemagglutination-related properties protein, such as (thermal, acid–base) stability, sugar binding specificity, ion characteristics, and hemolytic were detected. optimal combination was: time...
An imbalance of excitatory and inhibitory signals in the brain has been proposed to be one main pathological features various diseases related hypothalamic-pituitary-adrenal axis (HPAA) dysfunction. Excessive glutamate release induces neuronal excitotoxicity, while glutamic acid decarboxylase (GAD) 67 promotes transformation excessive γ-aminobutyric (GABA). Our previous studies demonstrated that prenatal ethanol exposure (PEE) causes foetal over-exposure maternal corticosterone...
Background: Despite the increasing adoption of Space GlucoseControl system (SGCs), a novel blood glucose management technique, in critically ill patients, its efficacy and safety warrant further investigation. Objective: This study aimed to assess SGCs managing patients with stress-induced hyperglycemia intensive care unit. Methods: A prospective was conducted involving 22 monitored using for 72 hours. Measurements included mean glucose, maximum minimum frequencies (> 8.3 mmol/L),...
The objective of this study was to explore the neuroprotective effect moxibustion on rats with Parkinson's disease (PD) and its mechanism. A model established in using a two-point stereotactic 6-hydroxydopamine injection right substantia nigra (SN) ventral tegmental area. received at Baihui (GV20) Sishencong (EX-HN1) acupoints for 20 minutes, six times week, 6 weeks. SN tissue histologically immunohistochemically examined. Differentially expressed genes (DEGs) were identified through RNA...
Cancer is second only to heart disease as a cause of death, despite improvements in its early diagnosis and precision medicine. Due the limitations commonly used anticancer methods such surgery, radiotherapy chemotherapy, biological therapy, especially probiotics lactic acid bacteria, has received widespread attention. Lactobacillus been proven inhibit proliferation variety cancer cells. In this work, effects cell-free culture supernatant serofluid dish (CCS1) Lactiplantibacillus plantarum...
Exopolysaccharides (EPSs) are highly heterogeneous natural polymers, can exhibit some unique bio-logical activities, such as anti-oxidation, inflammation regulation, anticancer and anti-viral etc. A new type of EPS was obtained from the fermentation supernatant Lactiplantibacillus plantarum YT013. However, low yield posed a challenge for further research application. Therefore, in this study, production process optimized, anti-cancer cells proliferation activity investigated. Identified best...
Aberrant activation of Wnt signaling is implicated in gliomagenesis. Propofol, the most commonly used intravenous anesthetic agent clinics, exhibits potent antitumor activity a variety cancer cells through different mechanisms. However, role propofol on and glioma cell growth remains to be fully elucidated. In present study, was identified as inhibitor signaling. 293T transfected with Wnt1 or Wnt3 expression plasmids treated Wnt3A-conditioned medium, significantly inhibited transcriptional...
Abstract Reports in recent years have suggested that adiponectin (APN) improves insulin resistance and inhibits apoptosis by activating the AMP-activated protein kinase (AMPK) pathway PI3K/Akt signaling after binding to its receptor. This study aims explore mechanism which APN reduces embryo loss rate trophoblast early pregnancy of mice with polycystic ovary syndrome (PCOS). PCOS were subcutaneously injected (10 μg mg kg −1 day ) on 11 consecutive days from 3rd onwards observe change induced...
Abstract Long-term, high dosage protamine zinc insulin (PZI) treatments produce adverse reactions. The trace element selenium (Se) is a candidate for the prevention of diabetes due to anti-oxidative stress activity and regulation glycometabolism. In this study, we aimed investigate anti-diabetic effects combination PZI Se on type 2 diabetes. Diabetic KKAy mice were randomized into following groups: model group groups that subcutaneously injected with PZI, Se, or low dose + 6 weeks. combined...
Cancer is a significant health burden in the world. Natural product drugs have received widespread attention because of their safety and effectiveness, stable effects fewer side effects. Some studies demonstrated that exopolysaccharide (EPS) from lactic acid bacteria (LAB) can inhibit growth many types cancer cells. In this work, EPS Lactiplantibacillus plantarum YT013 on gastric cells were investigated. Its cytotoxicity was evaluated by MTT assay; at concentration 1000 μg/mL, most...
To investigate the effects of Alisma and Rhizoma decoction on nonalcoholic steatohepatitis (NASH) to further shed light underlying mechanisms actions decoction.Plasma alanine aminotransferase (ALT) content was determined liver inflammation fibrosis were evaluated. Intrahepatocellular malondialdehyde superoxide dismutase contents using commercially available kits Furthermore, α-SMA expression in tissues examined by immunohistochemistry LC3-II detected immunoblotting assays.Mice receiving...
Context Qiancao Naomaitong Mixture (QNM) is mainly used to treat ischemic stroke patients in the clinic. Objective This study evaluates protective effect of QNM on neuronal damage vitro, and clarifies underlying mechanism against cerebral ischemia-reperfusion (I/R) injury vivo. Materials methods Activity assay caspase 3 (C-3) 8 (C-8) were measured with microplate reader cell apoptosis was investigated. Cerebral I/R induced by MCAO model. groups given at 0.27, 0.54 1.08 mL/100 g body weight....
Natural products play an important role in drug development and lead compound synthesis. Neocryptolepine is a polycyclic quinoline isolated from Cryptolepis sanguinolent. The cytotoxicity of neocryptolepine to gastric cancer cells AGS, MKN45, HGC27, SGC7901 was not very strong, it also had certain toxicity mucosa GES-1. Therefore, series derivatives were synthesized by the modification structure neocryptolepine, their evaluated. results showed that compounds C5 C8 exhibited strong AGS cells....