A5088204445- Corrosion Behavior and Inhibition
- Mine drainage and remediation techniques
- Metal Extraction and Bioleaching
- Synthesis and bioactivity of alkaloids
- Probiotics and Fermented Foods
- Cancer therapeutics and mechanisms
- Gut microbiota and health
- Microbial Metabolites in Food Biotechnology
- Quinazolinone synthesis and applications
- Ferroptosis and cancer prognosis
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- Genomics and Phylogenetic Studies
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
Lanzhou University
2016-2025
Hangzhou City University
2023
ABSTRACT Colorectal cancer (CRC) is a common accompanied by microbiome dysbiosis. Exploration of probiotics against oncogenic microorganisms promising for CRC treatment. Here, differential between and healthy control were analyzed. Antibacterial experiments, whole-genome sequencing, metabolic network reconstruction combined to reveal the anti- Fusobacterium nucleatum mechanism, which was verified co-culture assay mendelian randomization analysis. Sequencing results showed that F. enriched in...
ABSTRACT Colorectal cancer (CRC) is the third most common cancer, and it can be prevented by performing early screening. As a hallmark of human microbiome plays important roles in occurrence development CRC. Recently, blood has been proposed as an effective diagnostic tool for various diseases, yet its performance on CRC deserves further exploration. In this study, 133 feces 120 samples are collected, including healthy individuals, adenoma patients, patients. The cfDNA fecal genome subjected...
Isaindigotone is an alkaloid containing a pyrrolo-[2,1-b]quinazoline moiety conjugated with benzylidene group and isolated from the root of Isatis indigotca Fort. However, further anticancer activities this its derivatives have not been fully explored. In work, novel isaindigotone derivative was synthesized three different gastric cell lines one human epithelial line were used to study anti-proliferation effects BLG26. HGC27 cells AGS explore potential mechanisms. BLG26 exhibited better in...
Natural products play an important role in drug development and lead compound synthesis. Neocryptolepine is a polycyclic quinoline isolated from Cryptolepis sanguinolent. The cytotoxicity of neocryptolepine to gastric cancer cells AGS, MKN45, HGC27, SGC7901 was not very strong, it also had certain toxicity mucosa GES-1. Therefore, series derivatives were synthesized by the modification structure neocryptolepine, their evaluated. results showed that compounds C5 C8 exhibited strong AGS cells....
Cancer is a significant health burden in the world. Natural product drugs have received widespread attention because of their safety and effectiveness, stable effects fewer side effects. Some studies demonstrated that exopolysaccharide (EPS) from lactic acid bacteria (LAB) can inhibit growth many types cancer cells. In this work, EPS Lactiplantibacillus plantarum YT013 on gastric cells were investigated. Its cytotoxicity was evaluated by MTT assay; at concentration 1000 μg/mL, most...
Chemotherapy is commonly used clinically to treat colorectal cancer, but it usually prone drug resistance, so novel drugs need be developed continuously cancer. Neocryptolepine derivatives have attracted a lot of attention because their good cytotoxic activity; however, cytotoxicity studies on cancer cells are scarce. In this study, the 8-methoxy-2,5-dimethyl-5H-indolo[2,3-b] quinoline (MMNC) in was evaluated. The results showed that MMNC inhibits proliferation HCT116 and Caco-2 cells,...
Gigantol, a naturally occurring dibenzyl compound derived from various orchid species within the Dendrobium genus, exhibits notable pharmacological activity. We found that gigantol has significant anti-lung cancer properties, both in vitro and vivo, which it exerts through induction of ferroptosis. Furthermore, we gigantol's specific interaction with subunit solute carrier family 7 member 11 (SLC7A11) cystine/glutamate antiporter system (system Xc
Acidithiobacillus ferrooxidans ( A. ) is a gram-negative, extremely acidophilic, mesophilic, chemolithotrophic bacterium and the most well-studied acidophilic organism which usually found in acid environments such as mine drainage. The draft genome sequence of ATCC 23270 was first reported 2000, fourteen years ago. Here we describe features this organism, together with sequence, annotation. This from , 3,142,890 bp long single replicon its 32,719 protein-coding 64 RNA genes part Genomic...
Acidithiobacillus ferrooxidans ( A. ) is a gram-negative, extremely acidophilic, mesophilic, chemolithotrophic bacterium and the most well-studied acidophilic organism which usually found in acid environments such as mine drainage. The draft genome sequence of ATCC 23270 was first reported 2000, fourteen years ago. Here we describe features this organism, together with sequence, annotation. This from , 3,142,890 bp long single replicon its 32,719 protein-coding 64 RNA genes part Genomic...