A5045827612- Probiotics and Fermented Foods
- Quinazolinone synthesis and applications
- Synthesis and bioactivity of alkaloids
- Gut microbiota and health
- Cancer therapeutics and mechanisms
- Synthesis and Biological Activity
- Multiple Myeloma Research and Treatments
- Fermentation and Sensory Analysis
- Cancer Mechanisms and Therapy
- Synthesis and biological activity
- Cancer Research and Treatments
- Biochemical and biochemical processes
- Genomics, phytochemicals, and oxidative stress
- Genomics and Phylogenetic Studies
- Corrosion Behavior and Inhibition
- Metal Extraction and Bioleaching
- Polysaccharides Composition and Applications
- Glycosylation and Glycoproteins Research
- Bioactive Compounds and Antitumor Agents
- Polysaccharides and Plant Cell Walls
- Tea Polyphenols and Effects
- Food Quality and Safety Studies
- Minerals Flotation and Separation Techniques
- Microbial Metabolites in Food Biotechnology
- Computational Drug Discovery Methods
Lanzhou University
2020-2023
Shanghai University
2021
Colorectal cancer (CRC) is a common clinical malignancy globally ranked as the fourth leading cause of mortality. Some microbes are known to contribute adenoma-carcinoma transition and possess diagnostic potential. Advances in high-throughput sequencing technology functional studies have provided significant insights into landscape gut microbiome fundamental roles its components carcinogenesis. Integration scattered knowledge highly beneficial for future progress. In this study, literature...
Cancer is second only to heart disease as a cause of death, despite improvements in its early diagnosis and precision medicine. Due the limitations commonly used anticancer methods such surgery, radiotherapy chemotherapy, biological therapy, especially probiotics lactic acid bacteria, has received widespread attention. Lactobacillus been proven inhibit proliferation variety cancer cells. In this work, effects cell-free culture supernatant serofluid dish (CCS1) Lactiplantibacillus plantarum...
Exopolysaccharides (EPSs) are highly heterogeneous natural polymers, can exhibit some unique bio-logical activities, such as anti-oxidation, inflammation regulation, anticancer and anti-viral etc. A new type of EPS was obtained from the fermentation supernatant Lactiplantibacillus plantarum YT013. However, low yield posed a challenge for further research application. Therefore, in this study, production process optimized, anti-cancer cells proliferation activity investigated. Identified best...
A series of novel derivatives isaindigotone, which comes from the root isaits indinatca Fort, were synthesised (Compound 1-26). Four human gastrointestinal cancer cells (HCT116, PANC-1, SMMC-7721, and AGS) employed to evaluate anti-proliferative activity. Among them, Compound 6 displayed most effective inhibitory activity on AGS with an IC50 (50% concentration) value 2.2 μM. The potential mechanism study suggested that induced apoptosis in cells. collapse mitochondrial membrane (MMP) was...
Cancer is a significant health burden in the world. Natural product drugs have received widespread attention because of their safety and effectiveness, stable effects fewer side effects. Some studies demonstrated that exopolysaccharide (EPS) from lactic acid bacteria (LAB) can inhibit growth many types cancer cells. In this work, EPS Lactiplantibacillus plantarum YT013 on gastric cells were investigated. Its cytotoxicity was evaluated by MTT assay; at concentration 1000 μg/mL, most...
Colorectal cancer (CRC) is a common clinical malignant tumor and closely related to intestinal microbiome disorders. Especially, Fusobacterium nucleatum ( F. ) one of the most prevalent pathogens in CRC. However, its change CRC patients Northwest China, an area with high incidence gastrointestinal tumors, unclear, therapeutic strategies targeting remain unresolved. Here, fecal samples healthy people were studied using 16S rRNA sequencing explore microbial community alterations. Additionally,...
Isaindigotone is an alkaloid containing a pyrrolo-[2,1-b]quinazoline moiety conjugated with benzylidene group and isolated from the root of Isatis indigotca Fort. However, further anticancer activities this its derivatives have not been fully explored. In work, novel isaindigotone derivative was synthesized three different gastric cell lines one human epithelial line were used to study anti-proliferation effects BLG26. HGC27 cells AGS explore potential mechanisms. BLG26 exhibited better in...
Natural products play an important role in drug development and lead compound synthesis. Neocryptolepine is a polycyclic quinoline isolated from Cryptolepis sanguinolent. The cytotoxicity of neocryptolepine to gastric cancer cells AGS, MKN45, HGC27, SGC7901 was not very strong, it also had certain toxicity mucosa GES-1. Therefore, series derivatives were synthesized by the modification structure neocryptolepine, their evaluated. results showed that compounds C5 C8 exhibited strong AGS cells....
Acidithiobacillus ferrooxidans is a facultative anaerobe that depends on ferrous ion oxidation as well reduced sulfur to obtain energy and widely applied in metallurgy, environmental protection, soil remediation. With the accumulation of experimental data, metabolic mechanisms, kinetic models, several databases have been established. However, scattered data are not conducive understanding A. necessitates updated information informed by systems biology. Here, we constructed knowledgebase iron...
Serofluid dish is a popular fermented food in northwest China that contains abundant microorganisms. Advances of next-generation sequencing facilitate the elucidation bacterial community composition, yet roles fungi serofluid need further exploration. Here, internal transcribed spacer (ITS) and metatranscriptomics were conducted results showed dominant fungal communities belong to Candida Saccharomyces. Additionally, diversity, including phylogenetic diversity species richness, was largely...
As one of the key components common rail system, accuracy pressure field and velocity analysis pipe is related to service reliability. In order obtain distribution that difficult be measured in experiment, this paper considers using three-dimensional modeling establishing model oil flow based on fluid simulation software, then obtains through numerical simulation. The cone angle at nozzle structure compared analyzed. Meanwhile most appropriate angle’s processing among commonly used angles...
In drug development, the discovery of drugs with targeted properties often requires starting active lead compounds. The traditional process discovering compounds is costly, and virtual screening using large databases can be an emerging promising approach. Here, a combinatorial chemical molecular database was created by synthesis many unexplored small molecule building blocks from public through reaction amides, which uploaded to web for specific target protein CDK6 actual high fraction...
Background: Colorectal cancer (CRC) is a common clinical malignant tumor and closely related to intestinal microbiome disorders. Especially, F. nucleatum one of the most prevalent pathogens in CRC. However, therapeutic strategies targeting remain unresolved. Methods: Here, fecal samples healthy people CRC patients were collected studied using 16S rRNA sequencing. Additionally, antibacterial activity potential mechanism vanillin derivatives (IPM711 IPM712) explored. Findings: Results showed...