Abstract Background Endoplasmic reticulum (ER) stress is considered one of the mechanisms contributing to reactive oxygen species (ROS)- mediated cell apoptosis. In diabetic cardiomyopathy (DCM), apoptosis generally accepted as etiological factor and closely related cardiac ROS generation. ER proposed link between apoptosis; however, signaling pathways their roles in participating stress- induced DCM are still unclear. Methods this study, we investigated transductions ROS- dependent...

Baicalein, a widely used Chinese herbal medicine, has historically been in anti-inflammatory and anti-cancer therapies. However, the anti-metastatic effect molecular mechanism(s) of baicalein on hepatocellular carcinoma (HCC) remain poorly understood. Therefore, purpose this study was to assess effects related HCC. Based assays utilized both HCC cell lines an animal model, we found that inhibited tumor metastasis vivo vitro. Furthermore, after treatment with for 24 hours, there decrease...

Abstract Distal cholangiocarcinoma (dCCA) is a highly lethal malignancy that accounts for approximately 40% of patients with primary cholangiocarcinoma. Remarkable cellular heterogeneity and perineural invasion (PNI) are two typical features dCCA. Deciphering the complex interplay between neoplastic neural cells crucial understanding mechanisms propelling PNI-positive dCCA progression. Herein, we conduct single-cell RNA sequencing on 24,715 from pairs tumors adjacent tissues, identifying...

The looming antibiotic-resistance problem has imposed an enormous crisis on global public health and agricultural development. Even worse, the evolution widespread distribution of elements in bacterial pathogens have made resurgence diseases that were once easily treatable deadly again. development antibiotics with novel mechanisms action is urgently required.

Spatial-temporal hotspot pattern analysis of environmental pollution incidents provides an indispensable source information for the further development incident prevention measures. In this study, spatial-temporal patterns in China period 1995–2012 were analyzed, using Spatial Getis-Ord statistic and Improved Prediction Accuracy Index (IAPI). The results show that, period, occurrence exhibited a dynamic growth but then dropped continued to drop after year 2006, which was considered crucial...

Oxymatrine is an alkaloid obtained primarily from Sophora roots and has been shown to show anticancer effects in various cancers. However, the cellular molecular of this agent on cervical cancer have poorly characterized. Here, we investigated antitumor effect oxymatrine a human cell line (HeLa). Our results showed that application significantly inhibited growth tumorigenesis dose-dependent manner induced apoptosis through caspase-dependent pathways as determined using flow cytometry TUNEL...

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor with poor prognosis. This study aimed to investigate whether Hemoglobin, Albumin, Lymphocytes, and Platelets (HALP) score Tumor Burden Score (TBS) serves as independent influencing factors following radical resection in patients ICC. Furthermore, we sought evaluate the predictive capacity of combined HALP TBS grade, referred HTS develop prognostic prediction model. Methods Clinical data for ICC who...

Hepatocellular carcinoma (HCC) is the most common histological type of primary liver cancer and majority patients are diagnosed at an advanced stage have a poor prognosis. AKR1C3 (Aldo-keto reductase family 1 member C3) AKR1D1 D1) catalyze conversion aldehydes ketones to alcohols play crucial roles in multiple cancers. However, functions HCC remain unclear. In our study, data from public databases were selected as training validation sets, then 76 center chosen test set. Bioinformatics...

As one of the major alkaloid components in Sophoraflavescensait (kushen), oxymatrine has been used widely across world anti-inflammatory and anti-cancer therapies.However, effect metastasis hepatocellular carcinoma (HCC) related mechanism(s) are still unclear.The present study aimed to investigate anti-metastatic on HCC cells.Oxymatrine could also inhibit protein levels MMP-2/-9 a dose-dependent relationship.Moreover, reduces activity p38 signaling pathway via inhibiting phosphorylation...

Hepatocellular carcinoma (HCC) is one of the most common malignancies with poor outcomes. The main causes HCC-related deaths are recurrence and metastasis. Long noncoding RNAs (lncRNAs) recently identified as critical regulators in cancers. However, lncRNAs involved HCC metastasis poorly understood. In this study, via analyzing Cancer Genome Atlas Liver Carcinoma dataset, we a novel lncRNA LINC01134, which highly expressed tissues correlated microvascular invasion, macrovascular recurrence,...

To evaluate the role of P2Y1R in visceral hypersensitivity rats with experimental irritable bowel syndrome.A rat model syndrome was generated by intra-colonic administration acetic acid (AA) and assessed histology myeloperoxidase (MPO) activity assay. Then expression colonic tissue detected Western blot. In order to explore regulatory hypersensitivity, an agonist (MRS2365) antagonist (MRS2179) were intra-colonically administered effects tested through a colorectal distension test. The...

Hypoxia has crucial roles in cancer development and progression. Our previous study indicated that cell migration was increased a hypoxic microenvironment GBC-SD gallbladder (GBC) cells. Oridonin, bioactive diterpenoid compound is isolated from the plant Rabdosia rubescens, been identified as an anticancer agent various types of cancer. However, its proliferation, apoptosis, associated regulatory mechanisms have not yet to be fully elucidated GBC. The present investigated effect oridonin on...

Developing new agricultural bactericides is a feasible strategy for stopping the increase in resistance of plant pathogenic bacteria. Some pentacyclic triterpene acid derivatives were elaborately designed and synthesized. In particular, compound A

As a pro-inflammatory cytokine, Interleukin 17A (IL-17A) plays an important role in pathology of tumor microenvironment and inflammatory diseases. In this study, we intend to investigate the IL-17A on metastasis gallbladder cancer (GBC) related mechanisms. The serum levels were associated with node advanced stage. We also found pro-invasion effect GBC cells. When treated IL-17A, protein level epithelial marker E-cadherin cells was significantly down-regulated, while mesenchymal phenotype...

Abstract Objectives This study was designed to compare vascular contractile and relaxing responses G-protein coupled receptor agonists among the different regions of arteries following heat stress in rats. Methods Heat exposure performed by increasing internal temperature rats 42°C for 15 min. After 48 h, a myograph system used monitor rat renal, femoral mesenteric endothelin type B (ETB) receptor, A (ETA) serotonin α-adrenoceptor, respectively. In addition, calcitonin gene-related peptide...

<h3>Objective</h3> Left ventricular (LV) remodelling contributes to the development of cardiac dysfunction and is considered as a key determinant morbidity, mortality prognosis in patients who developed diabetic cardiomyopathy (DCM). Stimulation toll-like receptor 4 (TLR4) can lead impairment myocyte contractility activation several intracellular mediators such kinases, which are known critical regulators myocardial remodelling. Up-regulation TLR4 expression has been shown tissue mice. This...

Background: We aim to investigate the prevalence, patterns, risk factors, and outcomes of peritoneal metastases (PM) after curative laparoscopic hepatectomy (LH) for hepatocellular carcinoma (HCC). Methods: A multicenter cohort 2,138 HCC patients who underwent LH from August 2010 December 2016 seven hospitals in China was retrospectively analyzed. The incidence PM following evaluated compared with that open (OH) 1:1 propensity score matching (PSM). Results: prevalence 5.1% (15/295) early...

<title>Abstract</title> Distal cholangiocarcinoma (dCCA) is a highly lethal malignancy that accounts for approximately 40% of patients with primary cholangiocarcinoma. Remarkable cellular heterogeneity and perineural invasion (PNI) are two typical features dCCA. Deciphering the complex interplay between neoplastic neural cells crucial understanding mechanisms propelling PNI-positive dCCA progression. Herein, we conduct single-cell RNA sequencing on 24 715 from pairs tumors adjacent tissues,...

To1 improve updating efficiency and querying accuracy for spatial moving object data, we propose a parallel data structure indexing objects. The contains main index an auxiliary index, which are used supporting range based identity query operations, respectively. It also utilizes hooks operations to that may be influenced. Thus, it avoids locking relevant objects structures as existing approaches do when processed. At the same time, supports time slice semantics operations. Experimental...

<h3>Objective</h3> It has been mentioned that myocardial fibrosis which contributes to cardiac dysfunctions is one of the hall markers diabetic cardiomyopathy. Up-regulation reactive oxidative species (ROS)/TGF- beta 1/Smad signalling was described enhance collagen synthesis and fibroblasts proliferation through activating connective tissue growth factor (CTGF). As an essential trace element, selenium (Se) cardioprotective effects because its antioxidant property. However, role in...

<h3>Objective</h3> Previous studies have showed that TLR4 (Toll-like receptor 4) may trigger apoptosis of cardiomyocytes under conditions cardiac inflammation and oxidative stress. Studies also presented stress played an important role in the development diabetic cadiomyopathy. Selenium (Se) is essential trace element which known as antioxidant agent. This work aimed to investigate cadioprotective effect possible mechanism sodium selenite treatment experimental rats. <h3>Methods</h3>...

Hepatocellular carcinoma (HCC) is a major public health burden worldwide owing to high incidence and poor prognosis. Although numerous apoptotic genes were disclosed in HCC, the prognostic value clinical utility of remained unclear.The differentially expressed (DEGs) identified microarray RNA sequencing data from databases. The apoptosis-related (AR-DEGs) selected construct Lasso-penalized Cox regression model. signature including five was used calculate risk score. Then, receiver operating...