A5060984705- Synthesis and biological activity
- Plant-Microbe Interactions and Immunity
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Power Line Communications and Noise
- Blind Source Separation Techniques
- Mobile Ad Hoc Networks
- PAPR reduction in OFDM
- Plant Virus Research Studies
- Click Chemistry and Applications
- Fungal Plant Pathogen Control
- Cooperative Communication and Network Coding
- Plant Pathogenic Bacteria Studies
- Advanced Wireless Communication Techniques
- Advanced MIMO Systems Optimization
- Wireless Sensor Networks and IoT
- Synthesis and Biological Evaluation
- Advanced Adaptive Filtering Techniques
- Cancer therapeutics and mechanisms
- Wireless Communication Networks Research
- Asymmetric Hydrogenation and Catalysis
- Climate variability and models
- Pain Mechanisms and Treatments
- Embedded Systems and FPGA Design
- Advanced Algorithms and Applications
Guizhou University
2013-2025
Hirosaki University
2023-2025
Goodyear (United Kingdom)
2023
State Key Laboratory of Food Science and Technology
2023
Xinjiang University
2022
Soochow University
2022
Second Affiliated Hospital of Soochow University
2022
Ministry of Education of the People's Republic of China
2022
Institute of Medicinal Plant Development
2021
Chengdu University of Information Technology
2021
In this study, 24 indole derivatives containing 1,3,4-thiadiazole were discovered and synthesized. The target compounds' antifungal efficacy against 14 plant pathogenic fungal pathogens was then determined in vitro. With an EC50 value of 2.7 μg/mL, Z2 demonstrated the highest level bioactivity among them Botrytis cinerea (B.c.), exceeding concentrations control prescription drugs azoxystrobin (Az) (EC50 = 14.5 μg/mL) fluopyram (Fl) 10.1 μg/mL). underwent vivo testing on blueberry leaves...
Enolates are ubiquitous intermediates in organic synthesis. Among them, boron enolates exhibit distinctive reactivity patterns and selectivities due to the presence of a atom, making their synthesis highly attractive. Although methods for accessing ketone‐ or ester‐derived well‐developed, much less progress has been made development aldehyde‐derived aldehydes' high tendency toward self‐condensation. Therefore, practical applications significantly hindered. We present herein an efficient...
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) three human cancer cell lines including A549, PC-3, SMMC-7721. The results displayed that some the compounds had good activities, especially 2-{4-[(3-Fluoro-phenylimino)-methyl]-phenoxymethyl}-3-methyl-3H-quinazolin-4-one (5 g),...
The natural alkaloids of tryptanthrin and their derivatives have a wide range biological activities. In this research, four series azatryptanthrin containing 4-aza/3-aza/2-aza/1-aza were prepared by condensation cyclization reaction against plant pathogens to develop new product-based bacterial pesticide. Compound 4Aza-8 displayed remarkable growth inhibitory effect on pathogenic bacteria Xanthomonas axonopodis pv. citri (Xac), oryzae Oryzae (Xoo), Pseudomonas syringae actinidiae (Psa) with...
Herein, a new series of 2-chloro-N-(5-(2-oxoindolin-3-yl)-4H-pyrazol-3-yl) acetamide derivatives containing 1,3,4-thiadiazole (10a-i) and 4H-1,2,4-triazol-4-amine (11a-r) moiety was designed, synthesised as novel anticancer agents. The antiproliferative activity values indicated that compound 10 b stood the most potent derivative with IC50 12.0 nM against A549 K562 cells, respectively. Mechanism investigation docking studies it possessed good apoptosis characteristic dose-dependent growth...
In this study, 21 indole derivatives containing 1,3,4-oxadiazole were designed and synthesized, the results of biological activity test showed that target compound had certain antifungal against 12 plant pathogenic fungi in vitro, among which. E1 excellent bioactivity Botrytis cinerea (B.c.), Tomato (F.M.) Phomopsis sp (P.s.), with median effective concentration (EC50) values 2.8, 5.1 5.2 µg/mL, which are higher than those control drug azoxystrobin (Az) at 15.2, 31.2 15.2 µg/mL. vivo tests...
Dufulin is a new antiviral agent that highly effective against plant viruses and acts by activating systemic acquired resistance (SAR) in plants. In recent years, it has been used widely to prevent control tobacco rice viral diseases China. However, its targets mechanism of action are still poorly understood.Here, differential in-gel electrophoresis (DIGE) classical two-dimensional (2-DE) techniques were combined with mass spectrometry (MS) identify the target Dufulin. More than 40 proteins...
Plant bacterial illnesses are common and cause dramatic damage to agricultural goods all over the world, yet there few efficient bactericides alleviate them at present. To discover novel antibacterial agents, two series of quinazolinone derivatives with structures were synthesized their bioactivity against plant bacteria was tested. Combining CoMFA model search assay, D32 identified as a potent inhibitor Xanthomonas oryzae pv. Oryzae (Xoo), an EC50 value 1.5 μg/mL, much better in inhibitory...
The looming antibiotic-resistance problem has imposed an enormous crisis on global public health and agricultural development. Even worse, the evolution widespread distribution of elements in bacterial pathogens have made resurgence diseases that were once easily treatable deadly again. development antibiotics with novel mechanisms action is urgently required.
Xanthomonas oryzae pv. (Xoo) is often considered one of the most destructive bacterial pathogens causing leaf blight (BLB), resulting in significant yield and cost losses rice. In this study, a series novel derivatives containing isopropanolamine moiety linked to various substituted phenols piperazines were designed, synthesized screened.
Crystal structures of the tobacco mosaic virus (TMV) coat protein (CP) in its helical and disk conformations have previously been determined at atomic level. For structure, interactions proteins nucleic acids main chains were clearly observed; however, conformation residues C-terminus was flexible disordered. four-layer aggregate chain could only be observed through water-mediated hydrogen bonding with residues. In this study, effects C-terminal peptides on TMV CP investigated by crystal...
Detecting plant-derived signal molecules using fluorescent probes is a key topic and huge challenge for scientists. Salicylic acid (SA), vital defense hormone, can activate global transcriptional reprogramming to systemically express network of prominent pathogenesis-related proteins against invasive microorganisms. This strategy called systemic acquired resistance (SAR). Therefore, monitoring the dynamic fluctuations SA in subcellular microenvironments advance our understanding different...
Abstract In this paper 25 novel 5‐trifluoromethyl‐1 H ‐pyrazole‐4‐carboxamide derivatives were designed, synthesized, and evaluated for their in vitro anticancer antifungal activities; some exhibited good activity against cancer cells fungi. The IC 50 values of T1 , T4 T6 T7 A549 24.9, 21.9, 14.0, 10.2 μM, respectively, those T15 Thanatephorus cucumeris Botryosphaeria dothidea 22.0 27.7 μg/ml, respectively. A morphological study using FM SEM demonstrated that destroys the integrity...
5-Methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) are crucial epigenetic modifications in eukaryotic genomic DNA that regulate gene expression associated with the occurrence of various cancers. Here, we combined bisulfite conversion 4-acetamido-2,2,6,6-tetramethyl-1-oxopiperridinium tetrafluoroborate (ACT+BF4-, TCI) oxidation to develop a label-free sequence-independent isothermal amplification (BTIA) assay for genome-wide 5mC 5hmC analysis. The BTIA strategy can distinguish...
Enolates are ubiquitous intermediates in organic synthesis. Among them, boron enolates exhibit distinctive reactivity patterns and selectivities due to the presence of a atom, making their synthesis highly attractive. Although methods for accessing ketone‐ or ester‐derived well‐developed, much less progress has been made development aldehyde‐derived aldehydes' high tendency toward self‐condensation. Therefore, practical applications significantly hindered. We present herein an efficient...