A5048635954- Synthesis and biological activity
- Molecular Sensors and Ion Detection
- Cancer therapeutics and mechanisms
- Quinazolinone synthesis and applications
- X-ray Diffraction in Crystallography
- HER2/EGFR in Cancer Research
- Synthesis and Biological Evaluation
- Crystallization and Solubility Studies
- Sulfur Compounds in Biology
- Lung Cancer Treatments and Mutations
- Synthesis of Tetrazole Derivatives
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Luminescence and Fluorescent Materials
- Synthesis and pharmacology of benzodiazepine derivatives
- Fluoride Effects and Removal
- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Perovskite Materials and Applications
- Chemical Synthesis and Analysis
- Cell Adhesion Molecules Research
- Catalytic Cross-Coupling Reactions
- Multicomponent Synthesis of Heterocycles
- Microwave-Assisted Synthesis and Applications
- Synthetic Organic Chemistry Methods
Guizhou University
2019-2025
Guiyang Medical University
2020-2024
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2024
Guangdong University of Technology
2018-2020
Université Paris Cité
2020
Délégation Paris 7
2020
Délégation Paris 5
2020
Affiliated Hospital of Guizhou Medical University
2020
Guiyang University
2019
Sun Yat-sen University
2019
DTP specifically recognizes F − and allows for quantitative analysis in buffer solutions. In cellular imaging, releases red fluorescence upon recognition, enabling the visualization of fluoride within HepG2 cells.
In this paper, a series of novel 3-methyl-quinazolinone derivatives was designed, synthesised and evaluated for antitumor activity in vitro on wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) three human cancer cell lines including A549, PC-3, SMMC-7721. The results displayed that some the compounds had good activities, especially 2-{4-[(3-Fluoro-phenylimino)-methyl]-phenoxymethyl}-3-methyl-3H-quinazolin-4-one (5 g),...
In this paper, a set of 3-methylquniazolinone derivatives were designed, synthesised, and studied the preliminary structure-activity relationship for antiproliferative activities. All target compounds performed significantly inhibitory effects against wild type epidermal growth factor receptor tyrosine kinase (EGFRwt-TK) tumour cells (A431, A549, MCF-7, NCI-H1975). particular, compound 4d 3-fluoro-N-(4-((3-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)methoxy)phenyl)benzamide showed higher...
This paper described our efforts to develop dianilinopyrimidines as novel EGFR inhibitors. All the target compounds were tested for inhibitory effects against wild type (EGFRwt) and three tumour cells, including A549, PC-3, HepG2. Some of performed well in antitumor activities. Especially, compound 4c 2-((2-((4-(3-fluorobenzamido)phenyl)amino)-5-(trifluoromethyl) pyrimidin-4-yl)amino)-N-methylthiophene-3-carboxamide showed higher anti-tumour activities than Gefitinib. The IC50 values reached...
A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 kinase employed to evaluate their biological activities. The results shown that most the target compounds existed excellent antitumor In particular, IC50 values compound 9u (E)-3-((2-((4-(3-(3-fluorophenyl)acrylamido)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylthiophene-2-carboxamide against reached 0.35 μM, 3.24 5.12 0.091...
Although the long-term survival rate for leukemia has made significant progress over years with development of chemotherapeutics, patients still suffer from relapse, leading to an unsatisfactory outcome. To discover new effective anti-leukemia compounds, we synthesized a series dianilinopyrimidines and evaluated activities those compounds by using cell lines (HEL, Jurkat, K562). The results showed that dianilinopyrimidine analog H-120 predominantly displayed highest cytotoxic potential in...
为了寻求新型抗肿瘤药物,设计并合成了一系列新型1,3,4-噁二唑和1,3,4-噻二唑衍生物,对这些化合物在人类四种癌细胞:B-16(皮肤黑色素瘤细胞)、PC-3(人前列腺癌细胞)、U87(人原发性胶质母细胞瘤细胞)和A549(人非小细胞肺癌细胞)进行抗肿瘤活性评价.结果显示部分化合物具有较好的抗肿瘤活性,尤其是5-{6-[4-(2-羟基乙基)哌嗪-1-基]-2-甲基嘧啶-4-基氨基}-[1,3,4-噻二唑-2-羧酸(2-甲氧基苯基)酰胺(8b)和5-{6-[4-(2-羟基乙基)哌嗪-1-基]-2-甲基嘧啶-4-基氨基}-[1,3,4-噻二唑-2-羧酸(4-甲氧基苯基)酰胺(8c),对四种癌细胞都显示出较高的抗肿瘤活性,其抑制活性均优于阳性对照达沙替尼.随后对这类化合物抑制肿瘤的可能靶点开展了进一步研究.