Abstract Background This study aims to introduce the concept of habitat subregions and construct an accurate prediction model by analyzing refined medical images, predict lymph node metastasis (LNM) in patients with intrahepatic cholangiocarcinoma (ICC) before surgery, provide personalized support for clinical decision-making. Methods Clinical, radiological, pathological data from ICC were retrospectively collected. Using information arterial venous phases multisequence CT tumor delineated...

Several studies have demonstrated that neuroinflammation is the key to perioperative neurocognitive disorders (PND); however, specific mechanism postsurgery and anesthesia has not yet been fully clarified. The present study aimed at exploring effects of P2X4/NLRP3 signaling pathway in cognitive impairment after surgery. 12-14-month-old male C57BL/6 mice undergoing open tibial fracture surgery by sevoflurane were administered P2X4R inhibitor 5-BDBD or saline was intraperitoneally for 3...

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a highly malignant tumor with poor prognosis. This study aimed to investigate whether Hemoglobin, Albumin, Lymphocytes, and Platelets (HALP) score Tumor Burden Score (TBS) serves as independent influencing factors following radical resection in patients ICC. Furthermore, we sought evaluate the predictive capacity of combined HALP TBS grade, referred HTS develop prognostic prediction model. Methods Clinical data for ICC who...

Abstract Background Tumor morphology, immune function, inflammatory levels, and nutritional status play critical roles in the progression of intrahepatic cholangiocarcinoma (ICC). This multicenter study aimed to investigate association between markers related tumor with prognosis ICC patients. Additionally, a novel morphology score (TIIN score), integrating these factors was constructed. Methods A retrospective analysis performed on 418 patients who underwent radical surgical resection had...

Abstract Chronic inflammation is pivotal in the pathogenesis of hepatocellular carcinoma (HCC). Histamine a biologically active substance that amplifies inflammatory and immune response serves as neurotransmitter. However, knowledge histamine’s role HCC its effects on immunotherapy remains lacking. We focused histamine-related genes to investigate their potential HCC. The RNA-seq data clinical information regarding were obtained from Cancer Genome Atlas (TCGA). After identifying...

Melatonin exerts neuroprotective effects on isoflurane-induced cognitive impairment. However, the underlying mechanism has yet to be elucidated. The present study sought determine if melatonin confers its beneficial by acting mTOR, and it attenuates neuroinflammation in hippocampus of aged mice. A total 72 male C57BL/6 mice, 16-month-old, were randomly equally divided into six groups: (1) control group (CON); (2) rapamycin (RAP); (3) (MEL); (4) isoflurane (ISO); (5) rapamycin+ (RAP+ISO); (6)...

\textsf{Holant} is an essential framework in the field of counting complexity. For over fifteen years, researchers have been clarifying complexity classification for complex-valued on Boolean domain, a challenge that remains unresolved. In this article, we prove dichotomy domain when non-trivial signature odd arity exists. This based \textsf{\#EO}, and consequently $\text{FP}^\text{NP}$ vs. \#P as well, stating each problem either or \#P-hard. Furthermore, establish generalized version...

Many studies have shown that postoperative pain aggravates perioperative neurocognitive disorder (PND). In this study we aimed to clarify the effect of preoperative inflammatory on and cognitive function. We established model by injected complete freund adjuvant (CFA) PND tibial fracture surgery in 14- month-old C57BL/6 mice. The paw withdrawal threshold body weight mice were measured 7 days before 3 after surgery. On third day, subjected behavioral testing or sacrificed collect brain...

To develop and validate an MRI-based fusion model for preoperative prediction of perineural invasion (PNI) status in patients with intrahepatic cholangiocarcinoma (ICC). A retrospective collection 192 ICC from three medical centers (training set: n = 147; external test 45) was performed. Patients were classified into the PNI-positive PNI-negative groups based on postoperative pathological results. After image preprocessing, a total 1,197 features extracted T2-weighted imaging (T2WI). Feature...

Patients undergoing major surgeries may experience certain cognitive decline, which is known as postoperative delirium (POD) or dysfunction (POCD). We employed integrated behavioral Z-scoring introduced by Guilloux et al. (2011) to investigate the effects of fracture fixation under anesthesia on hippocampus-dependent memory in mice.ICR mice (12-14 months) underwent stabilized tibial operation sevoflurane anesthesia. They were subjected a battery successive tests following surgery, including...

Postoperative cognitive dysfunction (POCD) is a common complication after surgery, especially in aged patients. Neuroinflammation has been closely associated with the development of POCD. While contribution pneumoperitoneum to systemic inflammation well documented, effect pneumoperitoneal pressure on neuroinflammation and postoperative function remains unclear. In this study, we showed that high-pressure promoted microglial activation hippocampus aggravated impairment mice. These results...

During facemask ventilation, gastric insufflation is defined as appearance of a comet-tail or an acoustic shadow on ultrasonography. Ultrasonographic measurement antral cross-section area (CSA) may reflect insufflated antrum and provide interesting semi-quantitative data in regard to the insufflation. This study aimed determine appropriate level inspiratory pressure sufficient adequate pulmonary ventilation with lower occurrence during pressure-controlled using real-time ultrasonography...

Older individuals have been reported to suffer from cognitive disorders after surgery. Various types of surgical trauma used establish postoperative dysfunction (POCD) animal models in preclinical studies. However, few comparative analyses these were conducted.Tibial surgery, abdominal and extended surgery performed on aged ICR mice POCD models. Behavioral tests included open field, novel object recognition, fear conditioning, Morris water maze tests. The Z-score methodology was adopted...

This study was designed to investigate the role of pericytes in pathogenesis perioperative neurocognitive disorder (PND). In this study, we established a PND model via sevoflurane anesthesia and tibial fracture surgery 2-month-old 16-month-old male C57BL/6 mice. On third postoperative day, mice were subjected behavioral testing or sacrificed collect brain tissue. The progression hippocampal blood–brain barrier (BBB) disruption neuroinflammation detected using transmission electron microscope...

Objective: To investigate the effect of sleep fragmentation on perioperative neurocognitive disorders (PND) and central neuroinflammation by simulating patterns postoperative patients with in aged mice. Methods: Thirty-two elderly ICR mice were randomly divided into four groups (n=8): normal group (C), surgery (S), fragmented (F), surgery+fragmented (D). Fragmented was conducted after internal fixation tibia fractures, cognitive function evaluated novel object recognition (NOR) fear...

Objective: To investigate the predictive effect of major adverse cardiac events (MACE) in malignant obstructive jaundice (OJ) patients using plasma brain natriuretic peptide (BNP) level and surgical Apgar scoring (SAS) system.Methods: Forty one OJ undergoing treatments were studied at a single center. Pre-and postoperative BNP level, total bilirubin (TBil) data function (HR, CVP, CI, LVEF%) detected, SAS was calculated during surgery, relationship both with MACE after surgery...

The degree of inflammation and immune status is widely recognized to be associated with intrahepatic cholangiocarcinoma (ICC) closely linked poor postoperative survival. purpose this study was evaluate whether the systemic immune-inflammatory index (SII) albumin bilirubin (ALBI) grade together exhibit better predictive strength compared SII ALBI separately in patients ICC undergoing curative surgical resection.A retrospective analysis performed on a cohort 374 histologically confirmed who...

Objective:To investigate the clinical significance of detecting peripheral blood hepatocyte growth factor（HGF） in OSAHS patients.Method:Ninety-six cases patients our hospital were selected as group,and divided into 3 subgroups according to PSG results：mild,medium and severe. Each group included 32 cases,Thirty-five healthy persons control group. ELISA method was utilized detect HGF level blood. concentration measured with severe after months comprehensive treatment. The relationship between...

Objective: To investigate effects of two anesthesia methods on the first night sleep quality in middle-aged and elderly patients after surgery. Methods: This was a prospective study conducted from November 2017 to March 2018. Sixty patients, aged 50-70, undergoing elective surgery for unilateral lower extremity varicose vein at Ningbo No.2 Hospital, with American Society Anesthesiologists (ASA) grade Ⅰ or Ⅱ, were enrolled randomly allocated groups (n=30), general group spinal group. On day...