A5018672833- Dialysis and Renal Disease Management
- Nutritional Studies and Diet
- Potassium and Related Disorders
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Infrastructure Maintenance and Monitoring
- Cancer Risks and Factors
- Nutrition, Genetics, and Disease
- Healthcare Systems and Practices
- Heart Failure Treatment and Management
- BRCA gene mutations in cancer
- Diabetes Treatment and Management
- Renal function and acid-base balance
- Neurological and metabolic disorders
- Electrolyte and hormonal disorders
- Genetic Associations and Epidemiology
- Erythropoietin and Anemia Treatment
- Renal Transplantation Outcomes and Treatments
- Lipoproteins and Cardiovascular Health
- Organ Transplantation Techniques and Outcomes
- Multiple and Secondary Primary Cancers
- Gene expression and cancer classification
- Smoking Behavior and Cessation
- Metabolism and Genetic Disorders
- Asphalt Pavement Performance Evaluation
University of Tennessee Health Science Center
2016-2025
Centre de Médecine Préventive
2023
University of California, Irvine
2017-2020
University of Tennessee at Knoxville
2020
Memphis VA Medical Center
2018
Fred Hutch Cancer Center
2011-2017
Brigham and Women's Hospital
2014-2017
MedStar Health
2013-2017
Biomedical Research Institute
2013-2017
Cancer Research Center
2013-2017
This study investigates whether the incidence of new-onset diabetes mellitus (DM) is associated with statin use among postmenopausal women participating in Women's Health Initiative (WHI).The WHI recruited 161,808 aged 50 to 79 years at 40 clinical centers across United States from 1993 1998 ongoing follow-up. The current analysis includes data through 2005. Statin was captured enrollment and year 3. Incident DM status determined annually enrollment. Cox proportional hazards models were used...
A multi-ethnic study demonstrates that the extrapolation of genetic disease risk models from European populations to other ethnicities is compromised more strongly by structure than environmental or global background in differential associations across ethnicities.
IMPORTANCEUse of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk colorectal cancer.OBJECTIVE To identify common genetic markers that may confer differential benefit from or NSAID chemoprevention, we tested gene × environment interactions between regular use and/or NSAIDs single-nucleotide polymorphisms (SNPs) in relation to cancer. DESIGN, SETTING, AND PARTICIPANTSCase-control study using data 5 case-control cohort studies initiated 1976 2003...
Abstract BACKGROUND DNA methylation patterns differ among children and adults play an unambiguous role in several disease processes, particularly cancers. The origin of these differences is inadequately understood, this a question specific relevance to childhood adult cancer. METHODS levels at 26,485 autosomal CpGs were assayed 201 newborns (107 African American 94 Caucasian). Nonparametric analyses performed examine the relation between maternal parity, age, newborn gestational gender,...
Purpose Earlier Women's Health Initiative Dietary Modification trial findings suggested that a low-fat eating pattern may reduce breast cancers with greater mortality. Therefore, as primary outcome-related analysis from randomized prevention trial, we examined the long-term influence of this intervention on deaths result and after cancer during 8.5 years (median) dietary cumulatively for all diagnosed 16.1 follow-up. Patients Methods The randomly assigned 48,835 postmenopausal women normal...
Considerable efforts have been undertaken to relate single nutrients bone health. To this point, results are inconsistent. Suboptimal nutrient intake does not occur in isolation but rather reflects a poor diet quality.
Constipation is one of the most prevalent conditions in primary care settings and increases risk cardiovascular disease, potentially through processes mediated by altered gut microbiota. However, little known about association constipation with CKD. In a nationwide cohort 3,504,732 United States veterans an eGFR ≥60 ml/min per 1.73 m 2 , we examined status severity (absent, mild, or moderate/severe), defined using diagnostic codes laxative use, incident CKD, ESRD, change Cox models (for...
<h3>Importance</h3> Uric acid is a waste metabolite produced from the breakdown of purines, and elevated serum uric levels are associated with higher risk hypertension, cardiovascular disease, mortality progression chronic kidney disease (CKD). Treatment hyperuricemia in patients preexisting CKD has not been shown to improve outcomes, but associations acid–lowering therapies development new-onset estimated glomerular filtration rate (eGFR) within reference range no albuminuria unclear....
Changes in DNA methylation patterns with age frequently have been observed and implicated the normal aging process its associated increasing risk of disease, particularly cancer. Additionally, offspring older parents are at significantly increased cancer, diabetes, neurodevelopmental disorders. Only a proportion these risks among children can be attributed to nondisjunction chromosomal rearrangements. Using genome-wide survey 27,578 CpG dinucleotides cohort 168 newborns, we examined...
There is growing interest in identifying interventions that may increase health span by targeting biological processes underlying aging. The design of efficient and rigorous clinical trials to assess these requires careful consideration eligibility criteria, outcomes, sample size, monitoring plans. Experienced geriatrics researchers trialists collaborated provide advice on trial design. Outcomes based the accumulation incidence age-related chronic diseases are attractive for Accumulation...
Case–control studies have reported that exogenous estrogen use is associated with increased risk of skin cancer. The effects menopausal hormone therapy on incidence nonmelanoma cancer and melanoma were evaluated in post hoc analyses the Women's Health Initiative randomized placebo-controlled trials combined plus progestin (E + P) only (E-alone). Postmenopausal women aged 50–79 years randomly assigned to conjugated equine (0.625 mg/d) medroxyprogesterone acetate (2.5 or placebo E P trial if...
Abstract Background: Considerable evidence suggests that cigarette smoking is associated with a higher risk of colorectal cancer (CRC). What unclear, however, the impact quitting on attenuation and whether other factors for CRC modify this association. Methods: We conducted pooled analysis eight studies, including 6,796 cases 7,770 controls, to evaluate association between history investigate potential effect modification by factors. Results: Current smokers [OR, 1.26; 95% confidence...
Epidemiological studies of the association sodium and potassium intake with cardiovascular disease risk have almost exclusively relied on self-reported dietary data. Here, 24-hour urinary excretion assessments are used to correct self-report data for measurement error under assumption that urine recovery provides a biomarker differs from usual according classical model. Under this assumption, self-reports underestimate by 0% 15%, overestimate 8% sodium/potassium ratio ≈20% using food...
Background Heart failure (HF) is associated with poor cardiac outcomes and mortality. It not known whether HF leads to renal in patients normal kidney function. We hypothesized that worse long-term outcomes. Methods Results Among 3 570 865 US veterans estimated glomerular filtration rate (eGFR) ≥60 mL min −1 1.73 m −2 during October 1, 2004 September 30, 2006, we identified 156 743 an International Classification of Diseases , Ninth Revision diagnosis HF. examined the association incident...
Prior studies have suggested that arteriovenous fistula (AVF) or graft (AVG) creation may be associated with slowing of estimated glomerular filtration rate (eGFR) decline. It is unclear if this attributable to the physiological benefits a mature access on systemic circulation versus confounding factors. We examined nationwide cohort 3026 US veterans advanced chronic kidney disease (CKD) transitioning dialysis between 2007 and 2011 who had pre-dialysis AVF/AVG at least three outpatient eGFR...
While chronic kidney disease (CKD) is regularly evaluated among patients with diabetes, function may be significantly impaired before diabetes diagnosed. Moreover, disparities in the severity of CKD such a population are likely. This study extent national cohort 36,764 US veterans first diagnosed between 2003 and 2013 prior to initiating oral antidiabetic therapy. Evidence (any stage) at time diagnosis was determined using eGFR urine-albumin-creatinine ratios, odds which were assessed...
We examined the real-world comparative safety of sodium-glucose cotransporter-2 inhibitors (SGLT2i) vs. other newer anti-glycemic medications (dipeptidyl peptidase-4 [DPP4i], glucagon-like peptide-1 receptor agonists [GLP1a]) in patients with and without chronic kidney disease (CKD).
Introduction: Niacin is a non-statin lipid-lowering therapy that has been shown to lower triglycerides and improve other risk factors for renal outcomes. Despite these favorable data, the effect of niacin on long-term kidney outcomes remains unclear. The aim this study examine associations therapies with incident chronic disease (CKD), end-stage (ESRD), death in patients estimated glomerular filtration (eGFR) at least 60 mL/min/1.73 m2. Methods: In nationwide historic cohort 1,139,630 US...