A5078381092- Wound Healing and Treatments
- Proteoglycans and glycosaminoglycans research
- Periodontal Regeneration and Treatments
- Tendon Structure and Treatment
- Tissue Engineering and Regenerative Medicine
- Dermatologic Treatments and Research
- Glycosylation and Glycoproteins Research
- Bone Tissue Engineering Materials
- Electrospun Nanofibers in Biomedical Applications
- 3D Printing in Biomedical Research
- Nerve injury and regeneration
- Hydrogels: synthesis, properties, applications
- Antimicrobial Peptides and Activities
- Angiogenesis and VEGF in Cancer
- Polymer Surface Interaction Studies
- Laser Applications in Dentistry and Medicine
- Gold and Silver Nanoparticles Synthesis and Applications
- Galectins and Cancer Biology
- Diabetic Foot Ulcer Assessment and Management
- Neurogenesis and neuroplasticity mechanisms
- Advanced biosensing and bioanalysis techniques
- Chemokine receptors and signaling
- Polydiacetylene-based materials and applications
- Spinal Cord Injury Research
- Cellular Mechanics and Interactions
Leibniz Institute of Polymer Research
2015-2023
TU Dresden
2019
Duke University
2018
Glycosaminoglycan-based hydrogels scavenge proinflammatory chemokines, reduce the influx of immune cells, and improve healing chronic wounds.
A major limitation for the therapeutic applications of cytokines is their short half‐life time. Glycosaminoglycans (GAGs), known to complex and stabilize in vivo, are therefore used form 3D‐biohybrid polymer networks capable aiding effective administration Interleukin‐4, a key regulator inflammatory response. Mimicking vivo situation protease‐rich milieu, star‐shaped poly(ethylene glycol) (starPEG)‐heparin hydrogels starPEG reference without heparin loaded with Interleukin‐4 subsequently...
Abstract Adipose tissue‐derived stem cells (ASCs) have been shown to assist regenerative processes after spinal cord injury (SCI) through their secretome, which promotes several mechanisms, such as inducing axonal growth, reducing inflammation, promoting cell survival, and vascular remodeling, thus ultimately leading functional recovery. However, while systemic delivery (e.g., i.v. [intravenous]) may cause off‐target effects in different organs, the local administration has low efficiency...
Abstract Excessive inflammation often impedes the healing of chronic wounds. Scavenging chemokines by multiarmed poly(ethylene glycol)‐glycosaminoglycan (starPEG‐GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse skin wound model. Herein, textile‐starPEG‐GAG composite contact layer (WCL) capable selectively sequestering pro‐inflammatory is reported. Systematic variation local and integral charge densities starPEG‐GAG hydrogel component allows for tailoring its...
The anti-inflammatory cytokine IL-13 can be loaded and released from heparin-based cryogel biomaterials for sustained delivery to the brain.
Controlled release of active biomolecules is an attractive approach to modulate chemotactic gradients and accordingly the recruitment cells, e.g. endothelial progenitor cells improve wound healing or stimulate angiogenesis after myocardial infarction. Here, we developed variants hCXCL12, also named stromal cell-derived factor 1α, a chemokine that activates CXCR4 consequently recruits tissue specific stem cells. hCXCL12 were designed bind glycosaminoglycans (GAGs) with different affinities in...
Precision surface engineering is key to advanced biomaterials. A new platform of PEGylated styrene-maleic acid copolymers for adsorptive biofunctionalization reported. Balanced amphiphilicity renders the water-soluble but strongly affine surfaces. Fine-tuning their molecular architecture provides control over anchorage onto specific materials-which why they are referred as "anchor polymers" (APs)-and structural characteristics adsorbed layers. Conjugatable with an array bioactives-including...
Gold nanoparticles decorated with analyte recognition units can form the basis of colorimetric (bio)sensors. The presentation those may play a critical role in determining sensor sensitivity. Herein, we use model system to investigate effect architecture polymeric linker that connects gold units. Our results show number latter be adsorbed during assembly sensors depends on topology. We also this lead substantial differences performance, particularly situations which interactions are...
Event Abstract Back to StarPEG-heparin hydrogels as chemokine scavenger improve aberrant wound healing processes Nadine Lohmann1, 2, Lucas Schirmer2, 3, Elke Wandel1, Passant Atallah2, Inka Forstreuter1, Uwe Freudenberg2, Carsten Werner2, Jan C. Simon1, 2 and Sandra Franz1, 1 Leipzig University, Department of Dermatology, Venerology Allergology, Germany SFB-TRR67, Collaborative Research CenterMatrixengineering, 3 Center for Regenerative Therapies Dresden, Leibnitz Institute Polymer New ECM...
Wound Healing Excessive inflammation often impedes the healing of chronic wounds. In article number 2100293, Lucas Schirmer, Carsten Werner, and co-workers report a glycosaminoglycan hydrogelcoated wound contact layer capable selectively sequestering pro-inflammatory chemokines. A large animal model human disorders confirms that approach dampens without affecting pro-regenerative growth factors, thus expanding scope new anti-inflammatory therapy toward clinical use.
Event Abstract Back to The Dorsal Skin Fold Chamber as new model of delayed wound healing monitor the impact pro-angiogenic starPEG-heparin hydrogels on angiogenesis and outcome during skin regeneration Christian Beescho1, Teresa Schöpfer2, Lucas Schirmer3, Passant Atallah3, Uwe Freudenberg3, Carsten Werner3, Jan Christoph Simon2, Stefan Langer1 Sandra Franz2 1 University Hospital Leipzig, Plastic Reconstructive Surgery, Germany 2 Dermatology Venerology, 3 Max Bergmann Center Biomaterials,...
Event Abstract Back to starPEG-heparin hydrogels can by functionalized with TGFβ and support human dermal fibroblast growth differentiation Stephan Thoenes1, 2, Lucas Schirmer2, 3, Akira Watarai2, 4, Carsten Werner2, Jan C. Simon1, Uwe Freudenberg2, 3 Ulf Anderegg1, 2 1 Leipzig University, Dept. of Dermatology, Germany Dresden Collaborative Research Center (SFB-TR67) Matrixengineering, Technical University Dresden, Leibniz Institute Polymer Research, 4 Kitasato School Medicine, Department...
Event Abstract Back to Glycosaminoglycan - biohybrid hydrogels for the immune modulation in wound healing Lucas Schirmer1, Uwe Freudenberg1 and Carsten Werner1, 2 1 Leibniz-Institut für Polymerforschung Dresden, Max Bergmann Center of Biomaterials, Germany Technische Universität Regenerative Therapies Dresden (CRTD), Introduction: Chronic wounds represent a challenge conventional treatment. The underlying dysregulation inflammatory signals can lead severe impairment tissue regeneration. In...
Surface Biofunctionalization In article number 2102489, Carsten Werner, Uwe Freudenberg, and co-workers introduce a set of PEGylated styrene maleic acid(anhydride) copolymers with systematically varied molecular architecture—”anchor polymers”—and demonstrate their potentialities for adsorptive surface biofunctionalization bulk materials.