A5009413248- Marine Sponges and Natural Products
- Proteoglycans and glycosaminoglycans research
- Marine Biology and Environmental Chemistry
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Supramolecular Self-Assembly in Materials
- Electrospun Nanofibers in Biomedical Applications
- Microbial Natural Products and Biosynthesis
- Diatoms and Algae Research
- Nanocomposite Films for Food Packaging
- Computational Drug Discovery Methods
- Cellular Mechanics and Interactions
- Angiogenesis and VEGF in Cancer
- Chemical Synthesis and Analysis
- Connective tissue disorders research
- Hydrogels: synthesis, properties, applications
- Synthetic Organic Chemistry Methods
- Blood properties and coagulation
- Synthesis and biological activity
- Polymer Surface Interaction Studies
- Supramolecular Chemistry and Complexes
- Terahertz technology and applications
- Photochromic and Fluorescence Chemistry
- Glycosylation and Glycoproteins Research
- Calcium Carbonate Crystallization and Inhibition
Leibniz Institute of Polymer Research
2016-2025
Deutsche WindGuard (Germany)
2025
Max Bergmann Zentrum für Biomaterialien
2013-2020
TU Dresden
2009-2019
Queensland University of Technology
2019
Leibniz Association
2009-2014
Berlin-Brandenburger Centrum für Regenerative Therapien
2013
Institute of Information Technologies
2013
Moscow Power Engineering Institute
2012
ITMO University
2012
Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and regeneration. Studying angiogenesis vitro remains challenging because capillary morphogenesis endothelial cells (ECs) controlled by multiple exogenous signals. Therefore, a set situ-forming starPEG-heparin hydrogels was used to identify matrix parameters cellular interactions that best support EC morphogenesis. We showed particular type soft, metalloproteinase-degradable hydrogel containing covalently bound...
Poly(ethylene glycol)-peptide- and glycosaminoglycan-peptide conjugates obtained by a regio-selective amino acid protection strategy are converted into cell-instructive hydrogel matrices capable of inducing morphogenesis in embedded human vascular endothelial cells dorsal root ganglia. As service to our authors readers, this journal provides supporting information supplied the authors. Such materials peer reviewed may be re-organized for online delivery, but not copy-edited or typeset....
Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system deliver heparin in amounts triggered levels thrombin, key enzyme coagulation cascade, which—in turn—becomes inactivated due released heparin. The bio-responsive quantitatively quenches over several hours presence...
Sponges are probably the earliest branching animals and their fossil record dates back to Precambrian. Identifying skeletal structure composition is thus a crucial step in improving our understanding of early evolution metazoans. Here, we present discovery 505–million-year-old chitin, found exceptionally well preserved Vauxia gracilenta sponges from Middle Cambrian Burgess Shale. Our new findings indicate that, given right fossilization conditions, chitin stable for much longer than...
Sponges are a valuable source of natural compounds and biomaterials for many biotechnological applications. Marine sponges belonging to the order Verongiida known contain both chitin biologically active bromotyrosines. Aplysina archeri (Aplysineidae: Verongiida) is well bromotyrosines with relevant bioactivity against human animal diseases. The aim this study was develop an express method production naturally prefabricated 3D bromotyrosine-containing extracts simultaneously. This new based...
Abstract Today’s smallest energy storage devices for in-vivo applications are larger than 3 mm and lack the ability to continuously drive complex functions of smart dust electronic microrobotic systems. Here, we create a tubular biosupercapacitor occupying mere volume 1/1000 (=1 nanoliter), yet delivering up 1.6 V in blood. The geometry this nano-biosupercapacitor provides efficient self-protection against external forces from pulsating blood or muscle contraction. Redox enzymes living...
Abstract This review aims to report recent advances on decarboxylative reactions of amino acids catalyzed by transition metals or non‐metals and the growing opportunities they present in construction complex chemical scaffolds for applications encompassing natural product synthesis, synthetic methodology development, functional materials. Different have been highlighted such as radical, photoredox metal metal‐free coupling reactions. etc. The is divided into two main sections: one deals with...
Collembola, also known as springtails, are soil-dwelling arthropods that typically respire through the cuticle. To avoid suffocating in wet conditions, Collembola have evolved a complex, hierarchically nanostructured, cuticle surface repels water with remarkable efficiency. In order to gain more profound understanding of characteristics, chemical composition and architecture Tetrodontophora bielanensis was studied. A stepwise removal different layers enabled controlled access each layer...
Highly macroporous semisynthetic cryogel microcarriers can be synthesized for culturing stem cells and neuronal type cells. Growth factors loaded to heparin-containing show near zero-order release kinetics cell-loaded injected through a fine gauge cannula without negative effect on the These carriers applied cell transplantation applications.
Reduction of complexity the extracellular matrix (ECM) to a non-covalent structure with minimal chemically defined components represents an attractive avenue for understanding biology ECM. The resulting system could lead design tailor-made biomaterials that incorporate varying functionalities. Negatively charged glycosaminoglycans are major Their interaction positively proteins is important dynamic three-dimensional scaffold formation and function. We designed screened peptide motifs whose...
Naturally occurring three-dimensional (3D) biopolymer-based matrices that can be used in different biomedical applications are sustainable alternatives to various artificial 3D materials. For this purpose, chitin-based structures from marine sponges very promising substitutes. Marine the order Verongiida (class Demospongiae) typical examples of demosponges with well-developed chitinous skeletons. In particular, species belonging family Ianthellidae possess chitinous, flat, fan-like fibrous...
Diatoms are considered unicellular eukaryotic organisms exclusively depositing biogenic silica. Heretofore there has been no report of calcification by these algae. Here it is shown that calcium carbonate within the stalks Didymosphenia geminata , a nuisance species prolifically colonized streams and rivers globally, in origin occurs as network calcite nanofibers. The nanofibrous framework mineralized polysaccharide matrix imparts mechanical support to stalks, providing stability variable...
Marine sponges remain representative of a unique source renewable biological materials. The demosponges the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this study, we focus our attention, for first time, on marine sponge Ianthella labyrinthus Bergquist & Kelly-Borges, 1995 (Demospongiae: Verongida: Ianthellidae) as novel potential...