The β-amyloid precursor protein (APP) represents a type I transmembrane glycoprotein that is ubiquitously expressed. In the brain, it key player in molecular pathogenesis of Alzheimer disease. Its physiological function however less well understood. Previous studies showed APP up-regulated prostate, colon, pancreatic tumor, and oral squamous cell carcinoma. this study, we show has an essential role growth control colon cancer. Abundant staining was found human adenocarcinoma cancer tissue....

A new methodology has been developed for preparing α-functional polymers in a one-pot simultaneous polymerization/isocyanate "click" reaction. Our original synthetic strategy is based on the preparation of carbonyl-azide chain transfer agent (CTA) precursor that undergoes Curtius rearrangement situ during reversible addition-fragmentation (RAFT) polymerization yielding well-controlled α-isocyanate modified polymers. This overcomes numerous difficulties associated with synthesis mediator...

Plasmonic nanoparticles that can be manipulated with magnetic fields are of interest for advanced optical applications, diagnostics, imaging, and therapy. Alignment gold nanorods yields strong polarization-dependent extinction, use is appealing because they act through space quickly switched. In this work, cationic polyethyleneimine-functionalized superparamagnetic Fe3 O4 (NPs) deposited on the surface anionic coated bovine serum albumin. The (MagGNRs) obtained mixing maintain distinct...

The investigation and application of complex nanostructures requires the hierarchical arrangement distinct domains on a small scale. Herein, we report method to prepare planet-satellite arrangements using RAFT polymers. Our approach is based star polymers decorated with trithiocarbonate groups their outer periphery that attach gold surfaces thus provide polymer ability connect (larger) nanoparticle planets (smaller) satellites. By adjusting molecular weight polymeric linker, tailored...

Abstract The assembly of metal nanoparticles into supracolloidal structures unlocks optical features, which can go beyond synergistic combinations the properties their primary building units. This is due to inter‐particle plasmonic coupling effects, give rise emergent properties. motivation for this progress report twofold: First, it described how simulation approaches be used predict and understand clusters. These simulations may form basis rational design architectures, based on desired...

A strategy for the controlled assembly of gold nanocrystals into dispersed three-dimensional superstructures is presented. multifunctional RAFT agent was used to prepare multiblock polystyrene (4.4-17.8 kDa) with trithiocarbonate groups as junctions between individual blocks. Addition these polymers two-phase Brust-Schiffrin nanoparticles (4.1 nm) resulted in formation stable gold-nanoparticle assemblies toluene. TEM analysis revealed that interparticle distances can be tuned over an...

Planet-satellite nanostructures from RAFT star polymers and larger (planet) as well smaller (satellite) gold nanoparticles are analyzed in experiments computer simulations regarding the influence of arm number polymers. A uniform scaling behavior planet-satellite distances a function length was found both dried state (via transmission electron microscopy) after casting on surfaces colloidally dispersed small-angle X-ray scattering) when 2-, 3-, 6-arm were employed. This indicates that mainly...

The hierarchical self-assembly of distinct nanoelements into precisely ordered nanostructures requires efficient and flexible fabrication strategies. Herein, we report the precise bimetallic gold-planet-silver-satellite nanoparticle-arrangements employing RAFT star polymers as particle linker connecting gold nanoparticles (AuNPs) silver (AgNPs) with judiciously modified surface activity. strengths this approach include adjustability interparticle distances by tailoring polymer molar mass....

Structural plasticity and its control at the nanoscale are a vivid area of material science. In this contribution, we report conceptually simple versatile strategy for formation reconfigurable nanoparticle arrangements. The key role in our approach is played by star block copolymers from controlled radical RAFT polymerization, which fulfill dual task guiding particle arrangement also equipping nanomaterials with stimulus-responsiveness. By virtue their structure, polymers provide same time...

The preparation of nanoparticles and their targeted connection with other functional units is one key challenge in developing nanoscale devices. Herein, we report an experimental strategy toward the development anisotropic nanoparticle architectures. Our approach based on phase separation binary mixed polymer brushes gold surfaces leading to Janus-type structures, as revealed by scanning transmission electron microscopy energy-loss spectroscopy and, additionally, corroborated computer...

Nanoparticles (NPs) decorated with topographically or chemically distinct surface patches are an emerging class of colloidal building blocks functional hierarchical materials. Surface segregation polymer ligands into pinned micelles offers a strategy for the generation patchy NPs controlled spatial distribution and number patches. The thermodynamic nature this approach poses question about stability multiple on NP surface, as lowest energy state is expected carrying single patch. In present...

Abstract Identifying changes in the nanoscopic domain is a key challenge physicochemical sciences, where great interest on sensing complex processes that involve cellular biochemical reactions, chemical heterogeneities, contact forces, and other interfacial phenomena. This has stimulated development of diverse materials allow subtle environments to be "seen". The nano‐domain always been ability sense minute scale rapidly transduce information out for macroscopical observation. Ideally,...

The development of a straightforward method is reported to form hybrid polymer/gold planet-satellite nanostructures (PlSNs) with functional polymer. Polyacrylate type polymer benzyl chloride in its backbone as macromolecular tracer synthesized study localization within PlSNs by analyzing the elemental distribution chlorine. functionalized nanohybrid structures are analyzed scanning transmission electron microscopy, energy loss spectroscopy, and spectrum imaging. results show that RAFT...

Gold nanoparticle (AuNP) network structures featuring particles from the two-phase Brust-Schiffrin synthesis and linear RAFT oligomers of styrene with two multiple trithiocarbonate (TTC) groups along their backbone have been investigated in detail. Insights into internal these particle networks could be obtained small-angle X-ray scattering experiments, showing that primary AuNPs are cross-linked by employed molecular linker. The extent AuNP formation was means dynamic light UV/visible...

Abstract The formation of well‐defined, functional surfaces that incorporate the unique properties inorganic nanoparticles (NPs) requires robust and scalable fabrication strategies. Herein, we report a methodology for decoration polymer molds with plasmonic (gold) nanoparticle arrays. Wrinkled soft templates were used to assemble gold NPs (74 nm) into line These pre‐formed arrays transferred in subsequent step onto polycarbonate via an injection molding process. Scanning electron microscopy...

The solvophobicity-driven directional self-assembly of polymer-coated gold nanorods is a well-established phenomenon. Yet, the kinetics this process, origin site-selectivity in self-assembly, and interplay (attractive) solvophobic brush interactions (repulsive) electrostatic forces are not fully understood. Herein, we use combination time-resolved (vis/NIR) extinction spectroscopy finite-difference time-domain (FDTD) simulations to determine conversion profiles for assembly with polystyrene...

Abstract The chemical binding between metal nanoparticles and (semi-)conductive polymer layers is essential to control the (opto-)electronic properties of such hybrid materials. Current approaches that achieve a conjugated organic ligands demonstrated promising functional properties, but are based on tedious multi-step synthesis incorporate required moieties at chain ends targeted macromolecular species. Herein, we explore pre-functionalization gold with p -aminothiophenol subsequent...

Abstract We study the formation of hybrid polymer/inorganic colloidal particles with multicompartmentalized structure, comprising gold nanoparticles grafted polystyrene‐ block ‐poly(methacrylic acid) (PSt‐ ‐PMAA) diblock copolymer ligands, through experiments and molecular dynamics simulations. The PMAA blocks segregate into small satellite‐like domains that are separated by polystyrene spacer from nanoparticle core. Dialysis against water leads to re‐configuration formed structures unique,...

Dynamic hot-spot re-configuration in supracolloidal structures enables staged analyte uptake and subsequent boosted SERS capability.