A5026820522- Diabetes and associated disorders
- Pancreatic function and diabetes
- Mesenchymal stem cell research
- Immune cells in cancer
- Natural Antidiabetic Agents Studies
- Diet, Metabolism, and Disease
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Eosinophilic Esophagitis
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Products and Biological Research
- IL-33, ST2, and ILC Pathways
University of Belgrade
2021-2024
Recent data indicate the link between number and function of T regulatory cells (Treg) in gut immune tissue initiation development autoimmunity associated with type 1 diabetes (T1D). Since 3 innate lymphoid (ILC3) small intestine are essential for maintaining FoxP3+ Treg there no about possible role ILC3 T1D pathogenesis, aim this study was to explore ILC3-Treg during T1D. Mature diabetic NOD mice had lower frequencies IL-2-producing lamina propria (SILP) compared prediabetic mice....
Mesenchymal stem cells (MSCs) are known for their immunosuppressive properties. Based on the demonstrated anti-inflammatory effect of mouse MSCs from hair follicles (moMSCORS) in a murine wound closure model, this study evaluates potential preventing type 1 diabetes (T1D) C57BL/6 mice. T1D was induced mice by repeated low doses streptozotocin. moMSCORS were injected intravenously weekly basis. reduced incidence, insulitis stage, and preserved insulin production treated animals. primarily...
Aryl Hydrocarbon Receptor (AHR) ligands, upon binding, induce distinct gene expression profiles orchestrated by the AHR, leading to a spectrum of pro- or anti-inflammatory effects. In this study, we designed, synthesized and evaluated three indole-containing potential AHR ligands (FluoAHRL: AGT-4, AGT-5 AGT-6). All compounds were shown emit fluorescence in near-infrared. Their agonist activity was first predicted using silico docking studies, then confirmed luciferase reporter cell lines....
Type 1 diabetes (T1D) is an autoimmune disease with a strong chronic inflammatory component. One possible strategy for the treatment of T1D to stimulate regulatory arm immune response, i.e. promote function tolerogenic dendritic cells (tolDC) and T (Treg). Since both cell types have been shown be responsive aryl hydrocarbon receptor (AHR) activation, we used recently characterized member new class fluorescent AHR ligands, AGT-5, modulate streptozotocin-induced in C57BL/6 mice. Prophylactic...