A5034146784- Macrophage Migration Inhibitory Factor
- Nuclear Receptors and Signaling
- Immunotherapy and Immune Responses
- Tryptophan and brain disorders
- Ocular Oncology and Treatments
- Cell Adhesion Molecules Research
- GDF15 and Related Biomarkers
- Chronic Myeloid Leukemia Treatments
- Alzheimer's disease research and treatments
- Educational and Social Studies
- T-cell and B-cell Immunology
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Neuroscience and Neuropharmacology Research
- Cardiovascular Issues in Pregnancy
- Autoimmune and Inflammatory Disorders Research
- COVID-19 Clinical Research Studies
- Circular RNAs in diseases
- Immune Response and Inflammation
- Educational Tools and Methods
- Immune cells in cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
Università degli Studi di Enna Kore
2024-2025
Istituto Ortopedico Rizzoli
2023-2024
Centro Neurolesi Bonino Pulejo
2020-2023
Azienda Ospedaliera S.Giuseppe Moscati
2021-2022
University of Catania
2015-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2020
Ospedale Cannizzaro
2020
Sociedade Brasileira de Cirurgia Plástica
2020
University of Belgrade
2018-2019
Institute for Biological Research “Siniša Stanković”
2018-2019
There is recent evidence to indicate the existence of an inverse association between incidence neurological disorders and cancer development. Concurrently, transcriptional pathways responsible for onset glioblastoma multiforme (GBM) Alzheimer's disease (AD) have been found be mutually exclusive two pathologies. Despite advancements being made concerning knowledge molecular mechanisms development GBM AD, little known about identity microRNA (miRNAs or miRs) involved in progression these...
// Santa Mammana 1 , Placido Bramanti 2 Emanuela Mazzon Eugenio Cavalli Maria Sofia Basile Paolo Fagone Cristina Petralia 3 James Andrew McCubrey 4 Ferdinando Nicoletti and Katia Mangano Department of Biomedical Biotechnological Sciences, University Catania, Italy IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Educational Microbiology Immunology, Brody School Medicine, East Carolina University, Greenville, NC, USA Correspondence to: Fagone, email: paolofagone@yahoo.it Keywords: multiple...
Bladder cancer is one of the leading urinary tract. It often diagnosed at advanced stage disease. To date, no specific and effective early detection biomarkers are available. Cancer development progression associated with involvement both epithelial-mesenchymal transition (EMT) tumor microenvironment which NGAL/MMP-9 complex represents main player in bladder cancer. known that change microRNAs (miRNAs) expression may result gene modulation. Therefore, identification miRNAs EMT pathway be...
The macrophage migration inhibition factor (MIF) is a cytokine with multiple biological functions, including the cancer‑associated processes, cell cycle deregulation, angiogenesis and metastatization. present study investigated expression of MIF its functionally associated genes (D‑DT, CD74, CD44, CXCR2 CXCR4) in glioblastoma multiforme (GBM). data were obtained from Cancer Genome Atlas databank, through cBioportal web‑based utility (cbioportal.org/). A significant increase was observed...
Uveal melanoma (UM) is the most common primary intraocular cancer in adults. In present study, we aimed to characterize immunological features of UM and provide an association with prognostic markers outcome. Also, assessed influence microenvironment on expression inhibitory immune checkpoints UM. Genes interest included MHC Class I II molecules, as well immune-checkpoints, i.e. PDL1, PDL2, B7-H3, B7-H4, TBFRSF6B, CD47, CD155, GAL9, HVEM CD200. We observed significant lower levels genes...
Concanavalin A (ConA)‐induced hepatitis is an experimental model of human autoimmune induced in rodents by i.v. injection Con A. The disease characterized increase serum levels transaminases and massive immune infiltration the livers. Type 1, type 2, 17 cytokines play a pathogenic role development ConA‐induced hepatitis. To understand further immunoregulatory mechanisms operating regulation hepatitis, we have evaluated anti‐inflammatory pathway Nrf2/HO‐1/CO (Nuclear Factor E2‐related 2/Heme...
Tetraspanin 32 (TSPAN32), a member of the tetraspanin superfamily, is one several tumor-suppressing subtransferable fragments located in imprinted gene domain chromosome 11p15.5, critical tumor-suppressor region. Although biology TSPAN32 remains largely unexplored, accumulating evidence suggests its involvement hematopoietic functions. In this study, we performed comprehensive analysis expression patterns and regulatory roles TSPAN32. Notably, highly expressed immune cells, particularly...
Glioblastoma (GBM) is the most frequent and deadly form of primary malignant brain tumor among adults. A promising emerging approach for GBM treatment may be offered from HIV protease inhibitors (HIV-PIs). In fact, in addition to their pharmacological activity infection, they possess important anti-neoplastic effects. According previous studies, a nitric oxide (NO) donating group parental compounds can reduce toxicity enhance anticancer action various compounds, including HIV-PIs. this study...
The outbreak of the 2019 coronavirus disease (named, COVID‑19), caused by novel SARS‑CoV‑2 virus, represents a worldwide severe threat to public health. It is utmost importance characterize immune responses against and mechanisms hyperinflammation, in order design better therapeutic strategies for COVID‑19. In present study, transcriptomic analysis was performed profile signatures lung bronchoalveolar lavage fluid samples from COVID‑19 patients controls. Our data concordantly revealed...
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system autoimmune etiopathogenesis, and characterized by various neurological symptoms. Glatiramer acetate interferon‑β are administered as first‑line treatments for this disease. In non‑responsive patients, several second‑line therapies available, including natalizumab; however, percentage MS patients does not respond, or respond partially. Therefore, it utmost importance to develop diagnostic test prediction...