A5079640114- Transcranial Magnetic Stimulation Studies
- Cerebrovascular and Carotid Artery Diseases
- Neurological disorders and treatments
- Restless Legs Syndrome Research
- Functional Brain Connectivity Studies
- Stroke Rehabilitation and Recovery
- Parkinson's Disease Mechanisms and Treatments
- Pelvic floor disorders treatments
- Migraine and Headache Studies
- Long-Term Effects of COVID-19
- Pain Management and Treatment
- Vestibular and auditory disorders
- Sleep and Wakefulness Research
- Cardiomyopathy and Myosin Studies
- Spatial Neglect and Hemispheric Dysfunction
- Genetic Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
- Prostate Cancer Diagnosis and Treatment
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Neurological Disease Mechanisms and Treatments
- Urologic and reproductive health conditions
- Dementia and Cognitive Impairment Research
- Neurological Disorders and Treatments
- Muscle activation and electromyography studies
University of Catania
2016-2025
Sapienza University of Rome
2007-2025
Ospedale Cannizzaro
1998-2021
Policlinico Universitario di Catania
2010
Università Cattolica del Sacro Cuore
2003
Subanaesthetic doses of the N-methyl-D-aspartate (NMDA) antagonist ketamine have been shown to determine a dual modulating effect on glutamatergic transmission in experimental animals, blocking NMDA receptor activity and enhancing non-NMDA through an increase release endogenous glutamate. Little is known about effects excitability human central nervous system. The subanaesthetic, graded incremental (0.01, 0.02 0.04 mg kg-1 min-1, I.V.) cortical networks motor cortex were examined with range...
There is recent evidence to indicate the existence of an inverse association between incidence neurological disorders and cancer development. Concurrently, transcriptional pathways responsible for onset glioblastoma multiforme (GBM) Alzheimer's disease (AD) have been found be mutually exclusive two pathologies. Despite advancements being made concerning knowledge molecular mechanisms development GBM AD, little known about identity microRNA (miRNAs or miRs) involved in progression these...
Based on the hyperexcitability and disinhibition observed in patients with restless legs syndrome (RLS) following transcranial magnetic stimulation (TMS), we conducted a study low-frequency repetitive TMS (rTMS) over primary motor (M1) somatosensory cortical areas (S1) RLS.A total of 13 right-handed 10 age-matched controls were studied using clinical scales TMS. Measurements included resting threshold (rMT), motor-evoked potentials (MEPs), silent period (CSP), central conduction time (CMCT)....
Background Although cerebral white matter lesions (WMLs) are considered as a risk factor for vascular dementia, data on their impact hemodynamics scarce. We test and compare transcranial Doppler (TCD) features in WML patients with or without associated cognitive impairment. Methods A sample of non-demented elderly WMLs was consecutively recruited. Mean blood flow velocity (MBFV), pulsatility index (PI), peak systolic (PSV), end-diastolic (EDV), resistivity (RI) were recorded from the middle...
Motor evoked potentials (MEPs) to transcranial magnetic stimulation (TMS) are known be susceptible several sources of variability. However, conflicting evidences on individual characteristics in relatively small sample sizes have been reported. We investigated the effect age, height, and sex MEPs motor cortex spinal roots a large cohort.A total 587 subjects clinically neuroradiologically intact were included. recorded during mild tonic contraction through circular coil applied over "hot...
<i>Background:</i> Vascular damage of frontal-subcortical circuits involved in mood regulation and cognition might be the main contributor to pathogenesis late-life depression, it is linked poor response treatment. <i>Objective:</i> To investigate relationship between executive dysfunction outcome depressive symptoms among elderly patients with subcortical ischemic vascular disease. <i>Methods:</i> Ninety-two white matter lesions (WMLs) or lacunar infarcts...
Alzheimer's Disease (AD) is a neurodegenerative disorder affecting up to one third of individuals reaching the age 80. Different integrated responses exist in brain detect oxidative stress which controlled by several genes termed Vitagenes. Vitagenes encode for cytoprotective heat shock proteins (Hsp), as well thioredoxin, sirtuins and uncouple (UCPs). In present study we evaluate response mechanisms plasma lymphocytes AD patients, compared controls, order provide evidence an imbalance...
Major depression is one of the leading causes disabling condition worldwide and its treatment often challenging unsatisfactory, since many patients become refractory to pharmacological therapies. Transcranial magnetic stimulation (TMS) a noninvasive neurophysiological investigation mainly used study integrity primary motor cortex excitability cortico-spinal tract. The development paired-pulse repetitive TMS (rTMS) paradigms has allowed investigators explore pathophysiology depressive...
Introduction Celiac disease (CD) may initially present as a neurological disorder or be complicated by changes. To date, neurophysiological studies aiming to an objective evaluation of the potential central nervous system involvement in CD are lacking. Objective assess profile cortical excitability Transcranial Magnetic Stimulation (TMS) group de novo patients. Materials and methods Twenty patients underwent screening for cognitive neuropsychiatric symptoms means Mini Mental State...