A5002517355- Connexins and lens biology
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Medicinal Plants and Bioactive Compounds
- Mitochondrial Function and Pathology
- TiO2 Photocatalysis and Solar Cells
- Advanced Photocatalysis Techniques
- Nicotinic Acetylcholine Receptors Study
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Phytochemicals and Antioxidant Activities
- Neurological disorders and treatments
- Genetics, Aging, and Longevity in Model Organisms
- RNA regulation and disease
- Heme Oxygenase-1 and Carbon Monoxide
- Alzheimer's disease research and treatments
- Antioxidant Activity and Oxidative Stress
- Skin Protection and Aging
- Vitamin C and Antioxidants Research
- Heat shock proteins research
- Stress Responses and Cortisol
- Fungal Biology and Applications
- Yersinia bacterium, plague, ectoparasites research
- Sirtuins and Resveratrol in Medicine
University of Catania
2014-2024
Ospedale G.F. Ingrassia
2023
Research Centre for Olive Growing and Olive Oil Industry
2023
Saratov State Medical University
2016
Concordia University
1997-2016
Saratov State University
2014
University of Verona
2011
Istituto Nazionale Biostrutture e Biosistemi
2011
University of Palermo
2009
Hospital Clínico de la Universidad de Chile
2003
Titanium dioxide (TiO 2 ) has been noted (US Federal Register, 43FR38206, 25 August 1978) to be a safe physical sunscreen because it reflects and scatters UVB UVA in sunlight. However, TiO absorbs about 70% of incident UV, aqueous environments this leads the generation hydroxyl radicals which can initiate oxidations. Using chemical methods, we show that all samples tested catalyse photo‐oxidation representative organic substrate (phenol). We also sunlight‐illuminated catalyses DNA damage...
Abstract The connexins are the protein subunits of gap junction intercellular channels. In present study a new rat connexin was cloned by degenerate reverse transcription‐polymerase chain reaction and its gene isolated from mouse genomic library. nucleotide sequence encodes 321 amino acids (called Cx36) with highly significant homology to members family. situ hybridization analysis brain retina showed strongest expression in neurons inferior olive, olfactory bulb, CA3/CA4 hippocampal...
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic...
Abstract The term photocatalysis is one amongst several in a quagmire of labels used to describe photon-driven catalytic process; simple description proposed herein. Other such as quantum yield and/or efficiency solid/liquid and solid/gas hetero-geneous photocatalytic systems express process efficiencies have come refer (incorrectly) the ratio rate given event incident photons impinging on reactor walls typically for broadband radiation . There no accord expression efficiency. At times...
In developed countries, the extension of human life is increasingly accompanied by a progressive increase in neurodegenerative diseases, most which do not yet have effective therapy but only symptomatic treatments. recent years, plant polyphenols aroused considerable interest scientific community. The mechanisms currently hypothesized for pathogenesis Parkinson's disease (PD) are neuroinflammation, oxidative stress and apoptosis. Hydroxytyrosol (HT), main component Hidrox® (HD), has been...
Parkinson’s disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of population after age about 60 years old and 4% those over 80 old, causing motor impairments cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing by prevention disorders. In this regard, olive oil its biophenolic constituents like hydroxytyrosol (HT) have received growing...
Copper homeostasis and distribution is strictly regulated by a network of transporters intracellular chaperones encoded group genes collectively known as copper (CHGs). In this work, analysis The Cancer Genome Atlas database for somatic point mutations in colorectal cancer revealed that inactivating are absent or extremely rare CHGs. Using oligonucleotide microarrays, we found strong increase mRNA levels the membrane transporter 1 protein [CTR1; solute carrier family 31 member gene (SLC31A1...
Previous studies have provided evidence for the transcripts of Cx43 and Cx45 within pancreatic islets. As yet, however, it has proven difficult to unambiguously demonstrate expression these proteins by islet cells. We investigated whether Cx36, a new connexin species recently identified in mammalian brain retina, may also be expressed Using probes that permitted original identification Cx36 central nervous system, we show transcript is clearly detectable rat novel affinity-purified...
Abstract In the preceding article [Serpone and Salinaro, Pure Appl. Chem. , 71(2), 303-320 (1999)] we examined two principal features of heterogeneous photocatalysis that demanded scrutiny: (i) description (ii) process efficiencies. For latter proposed a protocol relative photonic efficiency which could subsequently be converted to quantum yields. A difficulty in expressing yield photochemistry is very nature system, either solid/liquid or solid/gas, places severe restrictions on measurement...
Abstract The identification of connexins (Cxs) expressed in neuronal cells represents a crucial step for understanding the direct communication between neurons and neuron glia. In present work, using double‐labelling method combining situ hybridization Cx mRNAs with immunohistochemical detection markers, we provide evidence that, among cerebral (Cx26, Cx32, Cx36, Cx37, Cx40, Cx43, Cx45 Cx47), only Cx36 are localized both developing adult rat brain. order to establish whether connexin...
There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional delaying the onset age-associated neurodegenerative diseases. Mushrooms have long used traditional medicine for thousands years, being now increasingly recognized as antitumor, antioxidant, antiviral, antibacterial hepatoprotective agent also capable to stimulate host immune responses.Here we provide evidence neuroprotective action Hericium Herinaceus when administered...
Amyloid deposits, constituted of amyloid beta (Aβ) aggregates, are a characteristic feature several neurodegenerative diseases, such as Alzheimer's, mild cognitive impairment and Parkinson's disease. They also have been recently implicated in the pathogenesis retinal damage, well age-related macular degeneration glaucoma. Glaucoma is progressive optic neuropathy characterized by gradual neuronal tissue due to ganglion cell loss, associated visual field loss over time resulting irreversible...
In rodents, carnosine treatment improves diabetic nephropathy, whereas little is known about the role and function of anserine, methylated form carnosine. Antioxidant activity was measured by oxygen radical absorbance capacity stress response in human renal tubular cells (HK-2) RT-PCR Western-Immunoblotting. wildtype (WT) mice (db/db), effect short-term anserine on blood glucose, proteinuria vascular permeability measured. Anserine has a higher antioxidant compared to (p < 0.001). stressed...
Meniere’s disease (MD) represents a clinical syndrome characterized by episodes of spontaneous vertigo, associated with fluctuating, low to medium frequencies sensorineural hearing loss (SNHL), tinnitus, and aural fullness affecting one or both ears. To date, the cause MD remains substantially unknown, despite increasing evidence suggesting that oxidative stress neuroinflammation may be central development endolymphatic hydrops consequent otholitic degeneration displacement in reuniting...