A5090000646- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Ocular Oncology and Treatments
- Intraocular Surgery and Lenses
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Historical and Environmental Studies
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Diverse academic and cultural studies
- Vascular Malformations Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Metabolism and Genetic Disorders
- Retinal Development and Disorders
- Urban Planning and Valuation
- Immunotherapy and Immune Responses
- Ophthalmology and Eye Disorders
- Analytical Chemistry and Chromatography
- Retinopathy of Prematurity Studies
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Cutaneous Melanoma Detection and Management
- Amino Acid Enzymes and Metabolism
University of Catania
2016-2025
EssilorLuxottica (France)
2025
Stazione Zoologica Anton Dohrn
2024
Elettra-Sincrotrone Trieste S.C.p.A.
2024
University of Trieste
2024
University of Naples Federico II
2024
Politecnico di Milano
2008-2023
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2016-2022
Regione Puglia
2022
Policlinico Universitario di Catania
2014-2021
In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients diagnosis Alzheimer's disease. We employed 14 outcome measures to assess functional and cognitive impairment. After 1 year, both treated placebo groups worsened, but group showed slower rate deterioration 13 measures, reaching statistical significance for Blessed Dementia Scale, logical intelligence, ideomotor...
Uveal melanoma (UM) represents approximately 5–6% of all diagnoses and up to 50% patients succumb their disease. Although several methods are available, accurate diagnosis is not always easily feasible because potential accidents (e.g., intraocular hemorrhage). Based on the assumption that profile circulating miRNAs often altered in human cancers, we verified whether UM showed different vitreous humor (VH) or serum miRNA profiles with respect healthy controls. By using TaqMan Low Density...
Age related macular degeneration (AMD) is the leading cause of blindness among people aged 50 and over. Retinal deposition amyloid-β (Aβ) aggregates in AMD patients has suggested a potential link between Alzheimer's disease (AD). We have evaluated differential retinal expression profile miRNAs rat model elicited by Aβ. A serum been also assessed using single TaqMan assay. Analysis retina from rats intravitreally injected with Aβ revealed that miR-27a, miR-146a, miR-155 were up-regulated...
Background Though several procedures of IOL implantation have been described (sutured scleral fixation, intra-scleral angle-supported anterior chamber, and chamber or retropupillary iris-claw IOLs), there are no randomized trials which comparing different techniques. Hence, the surgical treatment aphakia still remains controversial challenging. The purpose this study was to compare long-term efficacy rate complications versus posterior Iris-claw intraocular lenses (IOL) correct for without...
Background: COVID-19 is characterized by severe inflammation during the acute phase and increased aortic stiffness in early postacute phase. In other models, improved after reduction of inflammation. We aimed to evaluate mid- long-term effects on vascular cardiac autonomic function. The primary outcome was pulse wave velocity (aPWV). Methods: cross-sectional Study-1 included 90 individuals with a history 180 matched controls. longitudinal Study-2 41 patients randomly selected from who were...
Abstract Purpose To analyse the postoperative foveal avascular zone (FAZ) area, superficial vessel density (SVD) and deep (DVD) their correlation with functional (best‐corrected visual acuity, BCVA) anatomical outcomes (foveal macular thickness, FMT) after surgery for rhegmatogenous retinal detachment (RRD) repair. Method Patients RRD eyes, successfully treated a single pars plana vitrectomy (PPV) gas tamponade minimum 12 months follow‐up, were re‐examined. Foveal SVD, DVD FMT evaluated by...
The objective of this study was to report the authors' experience with long-term administration temozolomide (TMZ; > 6 cycles, up 101) in patients newly diagnosed glioblastoma and analyze its feasibility safety as well impact on survival. authors also compared data obtained from group undergoing TMZ treatment treated a standard protocol.A retrospective analysis conducted 37 who underwent operations for between 2004 2012. Volumetric postoperative Gd-enhanced MR images, within 48 hours,...
Amyloid deposits, constituted of amyloid beta (Aβ) aggregates, are a characteristic feature several neurodegenerative diseases, such as Alzheimer's, mild cognitive impairment and Parkinson's disease. They also have been recently implicated in the pathogenesis retinal damage, well age-related macular degeneration glaucoma. Glaucoma is progressive optic neuropathy characterized by gradual neuronal tissue due to ganglion cell loss, associated visual field loss over time resulting irreversible...
Objective: A severe dose-limiting axonal peripheral neuropathy may develop in subjects on treatment with the nucleoside analogues didanosine (ddI), zalcitabine (ddC), and stavudine (d4T). The impairment of mitrochondrial DNA synthesis is crucial to pathogenesis this disorder although other mechanisms have not been ruled out. depletion acetyl-carnitine, which regulates metabolism function nerves, could contribute neurotoxicity these compounds. Design: Non-randomized, cross-sectional study...
To evaluate the effect of posture change on subfoveal choroidal blood flow (ChBF) in normal volunteers.The pulsatile, nonpulsatile, and mean ChBF were measured with laser Doppler flowmetry 11 healthy volunteers a age 32 +/- 13 (SD) years. The subjects was changed from standing (90 degrees ), to supine (-8 back standing, mechanically driven table. During whole experimental procedure, heart rate (HR) continuously recorded. After 30 seconds position, tilted during approximately seconds. They...
Inhibitors of cyclin-dependent kinases (CDK) such as CDK2/cyclin A-E are currently undergoing clinical trials to verify their potential new anticancer agents. In a previous article we described the lead discovery process 3-aminopyrazole class inhibitors. The endpoint this was PNU-292137, compound endowed with in vivo antitumor activity mouse tumor xenograft model. We optimized improve some physicochemical properties, notably solubility and plasma protein binding. This optimization brought us...
<h3>Aim:</h3> To evaluate the long-term efficacy and safety of trabeculectomy with or without low-dosage Mitomycin-C (MMC) in primary open-angle glaucoma (POAG). <h3>Methods:</h3> 114 patients affected by POAG, participating a randomised clinical trial from 1995 to 1998, were re-examined their chart reviewed. Patients had undergone one eye intraoperative application (2 min) MMC (0.2 mg/ml) balanced saline solution (BSS), and, if indicated, postoperative laser suture lysis, bleb needling...
Uveal melanoma (UM) is the most common primary intraocular cancer in adults. In present study, we aimed to characterize immunological features of UM and provide an association with prognostic markers outcome. Also, assessed influence microenvironment on expression inhibitory immune checkpoints UM. Genes interest included MHC Class I II molecules, as well immune-checkpoints, i.e. PDL1, PDL2, B7-H3, B7-H4, TBFRSF6B, CD47, CD155, GAL9, HVEM CD200. We observed significant lower levels genes...