A5029269672- Alzheimer's disease research and treatments
- Trace Elements in Health
- Metabolomics and Mass Spectrometry Studies
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Mass Spectrometry Techniques and Applications
- Metabolism and Genetic Disorders
- Advanced Proteomics Techniques and Applications
- Heavy Metal Exposure and Toxicity
- Functional Brain Connectivity Studies
- Diet and metabolism studies
- Iron Metabolism and Disorders
- Vitamin D Research Studies
- Cancer-related Molecular Pathways
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Tryptophan and brain disorders
- Cystic Fibrosis Research Advances
- Olfactory and Sensory Function Studies
- Orthopaedic implants and arthroplasty
- Bacterial biofilms and quorum sensing
- Extraction and Separation Processes
- Plant Micronutrient Interactions and Effects
- Mental Health Research Topics
- Genetic Associations and Epidemiology
Università degli Studi di Enna Kore
2014-2023
University of Chieti-Pescara
2014-2023
In-Q-Tel
2012
Centro Studi Industriali
2007-2009
University of Parma
2003
A number of studies suggest that cancer stem cells are essential for tumour growth, and failure to target these can result in relapse. As this population has been shown be resistant radiation chemotherapy, it is understand their biology identify new therapeutic approaches. Targeting metabolism a potential alternative strategy counteract growth recurrence. Here we applied proteomic targeted metabolomic analysis order point out the main metabolic differences between breast grown as spheres...
The overall effect of brain zinc (Zn2+) in the progression and development Alzheimer's disease (AD) is still not completely understood. Although an excess Zn2+ can exacerbate pathological features AD, a deficit intake has also been shown to increase volume amyloid plaques AD transgenic mice. In this study, we investigated dietary supplementation (30 p.p.m.) mouse model 3xTg-AD, that expresses both β (Aβ)- tau-dependent pathology. We found greatly delays hippocampal-dependent memory deficits...
Background The pathogenic road map leading to Alzheimer's disease (AD) is still not completely understood; however, a large body of studies in the last few years supports idea that beside classic hallmarks disease, namely accumulation amyloid-β (Aβ) and neurofibrillary tangles, other factors significantly contribute initiation progression disease. Among them, mitochondria failure, an unbalanced neuronal redox state, dyshomeostasis endogenous metals like copper, iron, zinc have all been...
Previous studies have suggested that P. aeruginosa possesses redundant zinc uptake systems. To identify uncharacterized transporters, we analyzed the genome-wide transcriptional responses of PA14 to restriction. This approach led identification an operon (zrmABCD) regulated by regulator Zur, encodes for a metallophore-mediated import system. includes genes TonB-dependent Outer Membrane Protein (ZrmA) and putative nicotianamine synthase (ZrmB). The simultaneous inactivation ZnuABC transporter...
Galectins, a family of structurally related carbohydrate-binding proteins, contribute to different events associated with cancer biology, including apoptosis, homotypic cell aggregation, angiogenesis and tumor-immune escape. To interfere galectin–carbohydrate interactions during tumor progression, current challenge is the design specific galectin inhibitors for therapeutic purposes. Here, we report synthesis three novel low molecular weight synthetic lactulose amines (SLA): (1)...
Cardiovascular disease (CVD) is associated with vascular oxidative imbalance and inflammation. Increased reactive oxygen species (ROS) generation a functional inactivation of nitric oxide (NO) due to the reaction O₂⁻, leading peroxynitrite (ONOO⁻) formation subsequent reduction in beneficial effect NO bioavailability. Carotenoids'-rich diets have been decreased risk CVD, but underlying mechanism still unknown.In human umbilical vein endothelial cells (HUVECs), both β-carotene (BC) or...
Background Aging is a major co-risk factor in many neurodegenerative diseases. Cognitive enrichment positively affects the structural plasticity of aging brain. In this study, we evaluated effects set structured multimodal activities (Combination Training; CT) on cognitive performances, functional connectivity, and cortical thickness group healthy elderly individuals. CT lasted six months. Methodology Neuropsychological occupational performances were before at end training period. fMRI was...
Recent studies have shown that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive dysfunction or dementia. Insulin resistance often associated with T2DM and can induce defective insulin signaling in the central nervous system as well increase of impairment elderly. Glucagone like peptide-1 (GLP-1) an incretin hormone and, GLP-1 analogs, stimulates secretion has been employed treatment T2DM. analogs also enhance synaptic plasticity counteract deficits mouse models neuronal and/or...
Meniere’s disease (MD) represents a clinical syndrome characterized by episodes of spontaneous vertigo, associated with fluctuating, low to medium frequencies sensorineural hearing loss (SNHL), tinnitus, and aural fullness affecting one or both ears. To date, the cause MD remains substantially unknown, despite increasing evidence suggesting that oxidative stress neuroinflammation may be central development endolymphatic hydrops consequent otholitic degeneration displacement in reuniting...
In this study, we investigated the effects of long-term (9-month) treatment with pioglitazone (PIO; 20 mg/kg/d) in two animal models Alzheimer's disease (AD)-related neural dysfunction and pathology: PS1-KIM146V (human presenilin-1 M146V knock-in mouse) 3xTg-AD (triple transgenic mouse carrying AD-linked mutations) mice. We also on wild-type (WT) Mice were monitored for body mass changes, fasting glycemia, glucose tolerance, studied changes brain mitochondrial enzyme activity (complexes I...
The ability of a large number bacterial pathogens to multiply in the infected host and cause disease is dependent on their express high affinity zinc importers. In many bacteria, ZnuABC, transporter ABC family, plays central role process uptake poor environments, including tissues host. To initiate an investigation into relevance apparatus for Pseudomonas aeruginosa pathogenicity, we have generated znuA mutant PA14 strain. We found that this strain displays limited growth defect depleted...
Background There is growing debate on the use of drugs that promote cognitive enhancement. Amphetamine-like have been employed as enhancers, but they show important side effects and induce addiction. In this study, we investigated modafinil which appears to less compared other amphetamine-like drugs. We analyzed performances brain resting state network activity 26 healthy young subjects. Methodology A single dose (100 mg) was administered in a double-blind placebo-controlled study. Both...
Recent findings suggest that β-amyloid (Aβ) is more neurotoxic when present in its oligomeric configuration rather than as monomers or fibrils. Previous work from our laboratories has shown Aβ aggregation strongly influenced by the conjugation of peptide with metal ions (aluminum Α, copper [Cu], zinc [Zn], and iron [Fe]) are found high concentrations core senile plaques. Disruption Ca++ signaling mitochondrial dysfunction potent triggers neuronal death have been implicated loss associated...
The triple-transgenic Alzheimer (3 × Tg-AD) mouse expresses mutant PS1M146V, APPswe, and tauP301L transgenes progressively develops plaques neurofibrillary tangles with a temporal- region-specific profile that resembles the neuropathological progression of Alzheimer's disease (AD). In this study, we used proteomic approaches such as two-dimensional gel electrophoresis mass spectrometry to investigate alterations in protein expression occurring brain cerebellum 3 Tg-AD presenilin-1 (PS1)...
L-carnitine deficiency is commonly observed in chronic hemodialysis patients, and this depletion may cause clinical symptoms like muscle weakness, anaemia, hypotension.We pursued a targeted metabonomics investigation 28 patients (13 non diabetics 15 diabetics) 10 age-matched healthy controls, on plasma levels of all carnitine esters several amino acids. Samples were taken before after the first treatment week. Multiplexed data collected LCMRM (Multiple Reaction Monitoring) analysed by...
GluA1, GluA2, GluA3, and GluA4 are the constitutive subunits of AMPA receptors (AMPARs), major mediators fast excitatory transmission in mammalian central nervous system. Most AMPARs Ca2+-impermeable because presence GluA2 subunit. mRNA undergoes an editing process that results a Q to R substitution, key factor regulation AMPAR Ca2+-permeability. lacking or containing unedited subunit permeable Ca2+ Zn2+. The phenomenon physiologically modulates synaptic plasticity while, pathologic...
There is a growing interest on the role of autophagy in diabetes pathophysiology, where development neuropathy one most frequent comorbidities. We have previously demonstrated that neuropathic pain after nerve damage exacerbated autophagy-defective heterozygous Ambra1 mice. Here, we show existence prediabetic state mice, characterized by hyperglycemia, intolerance to glucose and insulin resistance. Thus, further investigate hypothesis prediabetes may account for exacerbation allodynia...
Abstract The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARSCoV-2), was declared a global pandemic the World Health Organization (WHO) on March 2020, causing unprecedented with million deaths across globe, mostly adults. Indeed, children accounted for only few percent of cases. Italy first Western country struck COVID-19 epidemic. Increasing age, which is one principal risk factors mortality, associated declined glutathione (GSH) levels. Over last...