A5076942056- Salivary Gland Disorders and Functions
- HIV/AIDS oral health manifestations
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Oral microbiology and periodontitis research
- Salivary Gland Tumors Diagnosis and Treatment
- Ocular Surface and Contact Lens
- Head and Neck Cancer Studies
- Systemic Lupus Erythematosus Research
- HIV, Drug Use, Sexual Risk
- Dental Research and COVID-19
- Telemedicine and Telehealth Implementation
- Blood donation and transfusion practices
- Cytomegalovirus and herpesvirus research
- Oral health in cancer treatment
- Viral-associated cancers and disorders
- Cervical Cancer and HPV Research
- HIV/AIDS Research and Interventions
- Dental Health and Care Utilization
- Systemic Sclerosis and Related Diseases
- Diabetes and associated disorders
- Blood transfusion and management
- Glaucoma and retinal disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Galectins and Cancer Biology
University of California, San Francisco
2016-2025
GTx (United States)
2016-2018
University Hospitals Cleveland Medical Center
2016
Newcastle University
2015
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015
Hospital Clínic de Barcelona
2015
Oklahoma Medical Research Foundation
2015
Blood Systems Research Institute
2009
Institut National de la Transfusion Sanguine
2009
University Teaching Hospital of Yaounde
2009
Objective To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). These were developed use in individuals with signs and/or symptoms suggestive SS. Methods We assigned preliminary importance weights to a consensus list candidate items, multi‐criteria decision analysis. tested adapted resulting draft existing cohort data on SS cases...
We propose new classification criteria for Sjögren's syndrome (SS), which are needed considering the emergence of biologic agents as potential treatments and their associated comorbidity. These target individuals with signs/symptoms suggestive SS.Criteria based on expert opinion elicited using nominal group technique analyses data from International Collaborative Clinical Alliance. Preliminary validation included comparisons classifications American–European Consensus Group (AECG) criteria,...
<h3>Objectives</h3> To develop and validate an international set of classification criteria for primary Sjögren9s syndrome (SS) using guidelines from the American College Rheumatology (ACR) European League Against Rheumatism (EULAR). These were developed use in individuals with signs and/or symptoms suggestive SS. <h3>Methods</h3> We assigned preliminary importance weights to a consensus list candidate items, multi-criteria decision analysis. tested adapted resulting draft existing cohort...
An increasing incidence of oral carcinoma among young adults has been reported in the U.S. and Europe. Although association between human papillomavirus infection tonsillar is now well established, to authors' knowledge little known about trends younger adults. The objective current study was explore both cavity pharyngeal squamous cell (SCC) populations, particular tongue SCC.Using 1973-2001 Surveillance, Epidemiology End Results (SEER) database, we computed age, race, site-specific...
To examine associations between labial salivary gland (LSG) histopathology and other phenotypic features of Sjögren's syndrome (SS).The database the International Collaborative Clinical Alliance (SICCA), a registry patients with symptoms possible SS as well those obvious disease, was used for present study. LSG biopsy specimens from SICCA participants were subjected to protocol-directed histopathologic assessments. Among 1,726 exhibiting any pattern sialadenitis, we compared diagnoses...
Abstract – Objectives: To explore changes in demographic distribution, incidence and survival rates of oral cancer the United States from 1973 through 1996. Methods: From Surveillance, Epidemiology, End Results (SEER) data, we computed proportion by characteristics, site, stage at diagnosis for 1973–84 1985–96. We estimated 5‐year relative age, gender, race/ethnicity, compared between two periods. The annual percent change (EAPC) was used to trends rate Results: Most tongue floor mouth...
To study the prevalence of extraglandular manifestations in primary Sjögren's syndrome (SS) among participants enrolled International Collaborative Clinical Alliance (SICCA) Registry.A total 1,927 SICCA registry were studied, including 886 who met 2002 American-European Consensus Group (AECG) criteria for SS, 830 "intermediate" cases had some objective findings SS but did not meet AECG criteria, and 211 control individuals. We studied immunologic hematologic laboratory abnormalities,...
Objective Sjögren's syndrome (SS) is an autoimmune disease that targets the salivary and lacrimal glands. While all patients demonstrate inflammatory infiltration abnormal secretory function in target tissues, features, pathology, clinical course can vary. Activation of distinct pathways may drive heterogeneity. The purpose this study was to investigate whether activation interferon (IFN) pathway correlates with key phenotypic features. Methods Clinical data 1 labial gland (stored frozen)...
Objective The Sjögren's International Collaborative Clinical Alliance (SICCA) is an international data registry and biorepository derived from a multisite observational study of participants in whom genotyping was performed on the Omni2.5M platform who had undergone deep phenotyping using common protocol‐directed methods. aim this to examine genetic etiology syndrome (SS) across ancestry disease subsets. Methods We genome‐wide association analyses SICCA subjects external controls obtained...
Major salivary gland ultrasonography (SGUS) is widely used for the diagnosis of primary Sjögren's syndrome (pSS). Our objective was to assess contribution SGUS compared other items 2016 ACR/EULAR pSS classification criteria, based on expert opinion.A secure web-based relational database by 24 experts from 14 countries 512 realistic vignettes developed data patients with suspected pSS. Each vignette provided criteria and information history, clinical symptoms findings. assessed 64 vignettes,...
Abstract Sjögren’s disease is a complex autoimmune with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel significant (GWS) regions in cases of European ancestry: CD247 , NAB1 PTTG1-MIR146A PRDM1-ATG5 TNFAIP3 XKR6 MAPT- CRHR1 RPTOR-CHMP6-BAIAP6 TYK2 SYNGR1 . Polygenic risk scores yield predictability (AUROC = 0.71) and relative 12.08. Interrogation bioinformatics databases refine the associations, define local regulatory networks GWS SNPs...
Abstract Purpose: Although an important risk factor for oral cancer is the presence of epithelial dysplasia, many lesions will not progress to malignancy. Matrix metalloproteinases (MMPs) are zinc-dependent proteinases capable digesting various structural components extracellular matrix. Because MMPs frequently overexpressed in squamous cell carcinoma (SCC), we hypothesized that they also dysplasias; those dysplasias express higher levels than do progress. Experimental Design: In this...
The Oral HIV/AIDS Research Alliance (OHARA) is part of the AIDS Clinical Trials Group (ACTG), largest HIV clinical trials organization in world. Its main objective to investigate oral complications associated with as epidemic evolving, particular, effects antiretrovirals on mucosal lesion development and fungal viral pathogens. OHARA infrastructure comprises: Epidemiologic Unit (at University California San Francisco), Medical Mycology Case Western Reserve University) Virology/Specimen...
Abstract Equatorial Africa has among the highest incidences of Kaposi's sarcoma (KS) in world, thus earning name “KS Belt.” This was case even before HIV epidemic. To date, there is no clear evidence that HHV‐8 seroprevalence higher this region but interpretation available literature tempered by differences serologic assays used across studies. We examined representatively sampled ambulatory adults Uganda, which Belt,” and Zimbabwe South are outside Belt, for antibodies. All were uniformly...
The importance of blood safety in public health was recognized long ago, and data are essential to plan strategies improve the status. This study aims obtain on donor donation characteristics that would complement from national international organizations.A questionnaire sent seven Francophone countries (Burkina Faso, Cameroon, Congo, Ivory Coast, Mali, Niger, Rwanda) structured objective donors donated administrative technical organization.The results reflect a poor level organization...
<h3>Objective</h3> To determine whether the Sjögren9s syndrome B (SSB)-positive/Sjögren9s A (SSA)-negative antibody profile is associated with key phenotypic features of SS. <h3>Methods</h3> Among registrants in International Collaborative Clinical Alliance (SICCA) possible or established SS, we compared anti-SSA/anti-SSB reactivity profiles against concurrent features. We fitted logistic regression models to explore association between and each SS feature, controlling for potential...
Abstract Objectives: To explore distribution of stage at diagnosis and relative survival rates among US adults with oral cavity cancer in relation to race, over time. Methods: We obtained 1973–2002 incidence data from the Surveillance, Epidemiology, End Results (SEER) Program, computed proportions for each site by diagnosis, tumor size, 5‐year Whites Blacks. Results: A total 46 855 cases were reported SEER registry ≥20 years between 1973 2002. African–Americans had a significantly higher...
Objective To explore changes in the phenotypic features of Sjögren's syndrome ( SS ), and status among participants International Collaborative Clinical Alliance SICCA ) registry over a 2–3‐year interval. Methods All who were found to have any objective measures salivary hypofunction, dry eye, focal lymphocytic sialadenitis minor gland biopsy, or anti‐ SSA / SSB antibodies recalled window 2 3 years after their baseline examinations repeat all clinical specimen collections determine whether...
To characterize the oral bacterial microbiome in HIV-infected participants at baseline and after 24 weeks of EFV/FTC/TDF.Thirty-five co-enrolled two AIDS Clinical Trials Group (ACTG) studies, A5272 A5280, with paired saliva samples complete data sets were assessed.Paired evaluated for using 16S rDNA PCR followed by Illumina sequencing. Diversity differential abundance was compared between groups. A random forest classification scheme used to determine contribution parameters classifying...
Abstract Sjögren’s disease (SjD) is a heterogeneous autoimmune disorder with significant clinical and molecular diversity. While anti-SSA antibodies serve as hallmark serological biomarker, nearly half of patients lack them, raising fundamental questions about distinct pathogenic mechanisms. To address this, we performed single-cell RNA sequencing surface protein profiling on 1.5 million PBMCs from 333 participants in the International Collaborative Clinical Alliance cohort, comparing those...