A5005955733- Autoimmune Neurological Disorders and Treatments
- Celiac Disease Research and Management
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Peripheral Neuropathies and Disorders
- Microscopic Colitis
- Monoclonal and Polyclonal Antibodies Research
- Cancer Immunotherapy and Biomarkers
- Ocular Diseases and Behçet’s Syndrome
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Genetics and Neurodevelopmental Disorders
- Chronic Lymphocytic Leukemia Research
- Galectins and Cancer Biology
- CAR-T cell therapy research
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Helicobacter pylori-related gastroenterology studies
- Salivary Gland Disorders and Functions
- vaccines and immunoinformatics approaches
- Contact Dermatitis and Allergies
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
Erasmus MC
2016-2025
Erasmus University Rotterdam
2014-2024
Université Claude Bernard Lyon 1
2024
Centre National de la Recherche Scientifique
2024
HPO Center (Netherlands)
2024
Inserm
2024
Maastricht University Medical Centre
2019-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2007-2023
Elisabeth-TweeSteden Ziekenhuis
2015-2023
Medisch Centrum Haaglanden
2020-2023
We recently isolated a cDNA clone that encodes the melanocyte lineage-specific antigen glycoprotein (gp)100. Antibodies directed against gp100 are an important tool in diagnosis of human melanoma. Since is highly expressed melanocytic cells, we investigated whether this might serve as target for antimelanoma cytotoxic T lymphocytes (CTL). Here, demonstrate tumor-infiltrating (TIL) derived from melanoma patient (TIL 1200) gp100. HLA-A2.1+ cells lysed by TIL patient. In addition, murine double...
This nationwide study gives a detailed description of the clinical features and long-term outcome anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis.We collected patients prospectively from October 2013, retrospectively samples sent to our laboratory January 2007. LGI1 antibodies were confirmed with both cell-based assay immunohistochemistry. Clinical information was obtained in interviews their relatives medical records. Initial MRI follow-up revised blindly. Neuropsychological...
To report a large cohort of patients with antibodies against contactin-associated protein-like 2 (Caspr2) and provide the clinical spectrum this disorder.Serum CSF samples were assessed at neuroimmunology centers in Barcelona Rotterdam. Patients included if Caspr2 confirmed independent techniques, including brain immunohistochemistry cell-based assay. Clinical information was obtained by authors or provided treating physicians after patients' informed consent.Median age symptom onset 66...
<h3>Objective</h3> This nationwide cohort study evaluates seizure responses to immunotherapy and antiepileptic drugs (AEDs) in patients with anti-leucine-rich glioma-inactivated 1 (LGI1), anti-NMDA receptor (NMDAR), anti-gamma-aminobutyric-acid B (GABA<sub>B</sub>R) encephalitis. <h3>Methods</h3> Anti-LGI1, anti-NMDAR, anti-GABA<sub>B</sub>R encephalitis new-onset seizures were included. Medical information about disease course, AEDs immunotherapies used, effects, side effects collected....
To report the main syndrome of dipeptidyl-peptidase-like protein 6 (DPPX) antibody-associated encephalitis, immunoglobulin G (IgG) subclass, and antibody effects on DPPX/Kv4.2 potassium channels.A retrospective analysis new patients cases reported since 2013 was performed. IgG subclass antibodies cultured neurons were determined with described techniques.Nine identified (median age 57 years, range 36-69 years). All developed severe prodromal weight loss or diarrhea followed by cognitive...
<h3>Objective</h3> Antibodies against glutamic acid decarboxylase 65 (anti-GAD65) are associated with a number of neurologic syndromes. However, their pathogenic role is controversial. Our objective was to describe clinical and paraclinical characteristics anti-GAD65 patients analyze response immunotherapy. <h3>Methods</h3> Retrospectively, we studied (n = 56) positive any symptom. We tested serum CSF ELISA, immunohistochemistry, cell-based assay. Accordingly, set cutoff value 10,000 IU/mL...
Abstract In a randomized clinical trial of 86 hospitalized COVID-19 patients comparing standard care to treatment with 300mL convalescent plasma containing high titers neutralizing SARS-CoV-2 antibodies, no overall benefit was observed. Using comprehensive translational approach, we unravel the virological and immunological responses following disentangle which may should be focus future studies. Convalescent is safe, does not improve survival, has effect on disease course, nor enhance viral...
We describe the effect on neonate of administration rituximab to a woman with idiopathic thrombocytopenic purpura (ITP). Rituximab, an anti-CD20 antibody, was given weekly for 4 weeks ITP in her third trimester pregnancy. One month after last healthy girl born. She had normal growth and development during first six months. At birth, B-lymphocytes were not detectable. Rituximab levels mother 24000 6700 ng/mL, respectively. Only 7 cases pregnancy described. No adverse events are described...
Enterocyte damage is the hallmark of coeliac disease (CD) resulting in malabsorption. Little known about recovery enterocyte and its clinical consequences. Serum intestinal fatty acid binding protein (I-FABP) a sensitive marker to study damage.To evaluate severity adult-onset CD course upon gluten-free diet (GFD). Furthermore, correlation among damage, autoantibodies histological abnormalities during studied.Serum I-FABP levels were determined 96 biopsy-proven adult patients 69 repeatedly...
To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2.VGKC-positive were tested for Caspr2 antibodies. Patients both matched (1:2) VGKC-negative patients. Clinical paraclinical criteria used blindly determine evidence autoimmune inflammation groups. with an inconclusive VGKC titer analyzed same way.A total 1,455 by radioimmunoassay. Fifty-six positive, 50 whom available be included. Twenty-five had (n =...
Leucine‐rich glioma‐inactivated1 (LGI1) encephalitis is an antibody‐associated inflammation of the limbic area. An autoimmune etiology suspected but not yet proven. We performed human leukocyte antigen (HLA) analysis in 25 nontumor anti‐LGI1 patients and discovered a remarkably strong HLA association. HLA‐DR7 was present 88% compared to 19.6% healthy controls ( p = 4.1 × 10 −11 ). HLA‐DRB4 all 46.5% 1.19 −7 These findings support hypothesis. exploratory small group 4 tumor‐LGI1 patients. The...
<h3>Objective</h3> To provide detailed long-term outcome data of children and adolescents following pediatric anti-<i>N</i>-methyl-d-aspartate receptor (anti-NMDAR) encephalitis, to identify neuropsychological impairments, evaluate the influence these factors on quality life (QoL). <h3>Methods</h3> All Dutch diagnosed with anti-NMDAR encephalitis were identified. Patients currently aged 4 years or older included in follow-up study, consisting a visit our clinic for interview standardized...
AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease (AN-PEP) to mitigate im-munogenic effects gluten in celiac patients. METHODS:Patients with initial diagnosis disease as confirmed by positive serology subtotal or total villous atrophy on duodenal biopsies who adhere a strict gluten-free diet (GFD) resulting normalised antibodies mucosal healing classified Marsh 0 Ⅰ were included.In randomised double-blind placebo-controlled pilot study, patients consumed toast...
Abstract Purpose To analyse intraocular cytokine levels and prevalence of antiretinal antibodies ( ARA s) in patients with retinitis pigmentosa RP ), age‐related macular degeneration AMD glaucoma cataract, correlate the results to clinical manifestations. Methods We collected fluid samples from n = 25), 12), 28) cataract 22), serum paired fluids N 7) 10). Interleukin IL )‐1 β , ‐1ra, ‐2, ‐6, ‐6r α ‐7, ‐8, ‐10, ‐17A, ‐23, thymus‐ activation‐regulated chemokine TARC monocyte chemoattractant...
To assess the relationships between systemic IFN type I (IFN-I) and II (IFN-II) activity disease manifestations in primary SS (pSS). RT-PCR of multiple IFN-induced genes followed by principal component analysis whole blood RNA 50 pSS patients was used to identify indicator IFN-I IFN-II activities. Systemic activation levels were analysed two independent European cohorts (n = 86 55, respectively) their with clinical features analysed. Three groups could be stratified according activity:...
Objective In newly diagnosed paediatric patients with moderate-to-severe Crohn’s disease (CD), infliximab (IFX) is initiated once exclusive enteral nutrition (EEN), corticosteroid and immunomodulator therapies have failed. We aimed to investigate whether starting first-line IFX (FL-IFX) more effective achieve maintain remission than conventional treatment. Design this multicentre open-label randomised controlled trial, untreated a new diagnosis of CD (3–17 years old, weighted Paediatric...
In this study we report the clinical features of 32 patients with gamma aminobutyric acid B receptor (GABABR) antibodies, identify additional autoantibodies in anti-GABABR encephalitis that mark presence an underlying small cell lung carcinoma and optimize laboratory methods for detection GABABR antibodies. Patients (n = 3225) were tested antibodies using cell-based assay, immunohistochemistry live hippocampal neurons. Clinical data obtained retrospectively. Potassium channel tetramerization...
Background: Thyroid dysfunction is among the most common adverse effects during anti-programmed cell death 1 (PD-1) immunotherapy, and alongside correlations with elevated anti-thyroid antibodies (ATAb), studies have found survival. However, exact relations remain to be clarified. We, therefore, aimed at clarifying relationship between thyroid dysfunction, ATAbs, survival in anti-PD-1 treated cancer patients. Methods: We included 168 patients nonsmall-cell lung carcinoma, renal metastatic...
Quantitative or qualitative differences in immunity may drive clinical severity COVID-19. Although longitudinal studies to record the course of immunological changes are ample, they do not necessarily predict progression at time hospital admission. Here we show, by a machine learning approach using serum pro-inflammatory, anti-inflammatory and anti-viral cytokine anti-SARS-CoV-2 antibody measurements as input data, that COVID-19 patients cluster into three distinct immune phenotype groups....
The clinical criteria for autoimmune encephalitis (AE) were proposed by Graus et al. in 2016. In this study, the AE validated real world, and common mimics described. addition, probable anti-LGI1 validated.