A5091259872- Autoimmune Neurological Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Genetics and Neurodevelopmental Disorders
- Herpesvirus Infections and Treatments
- CNS Lymphoma Diagnosis and Treatment
- Chemokine receptors and signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA regulation and disease
Erasmus MC
2021-2025
Medisch Centrum Haaglanden
2021-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2021-2023
Amsterdam Neuroscience
2023
Vrije Universiteit Amsterdam
2023
Leiden University
2023
Elisabeth-TweeSteden Ziekenhuis
2021
Radboud University Nijmegen
2021
Radboud University Medical Center
2021
University Medical Center
2021
The clinical criteria for autoimmune encephalitis (AE) were proposed by Graus et al. in 2016. In this study, the AE validated real world, and common mimics described. addition, probable anti-LGI1 validated.
Abstract Anti-Leucine-rich glioma inactivated-1 (LGI1) and anti-contactin-associated-protein-2 (CASPR2) autoimmune encephalitis (AIE) are common characterized by pathogenic antibodies targeting neuronal autoantigens. However, the drivers of antibody-secreting cells (ASC) involvement T remain unresolved. We performed single cell RNA-sequencing fresh cerebrospinal fluid (CSF) parallel blood samples 15 patients with LGI1- (n=9) CASPR2-AIE (n=6) compared to control (multiple sclerosis (MS) n=15,...
Autoimmune encephalitis (AIE) may present with prominent cognitive disturbances without overt inflammatory changes in MRI and CSF. Identification of these neurodegenerative dementia diagnosis mimics is important because patients generally respond to immunotherapy. The objective this study was determine the frequency neuronal antibodies presumed describe clinical characteristics antibodies.In retrospective cohort study, 920 were included from established cohorts at 2 large Dutch academic...
Autoimmune encephalitis (AIE) and paraneoplastic neurologic syndromes (PNSs) encompass a heterogeneous group of antibody-associated disorders. Both the number commercially available antibody tests have increased considerably over past decade. High-quality population-based data on epidemiology these disorders real-world performance are needed.
Abstract Objective A substantial part of central nervous system (CNS) disorders remains unexplained, despite various new and minimally invasive diagnostic techniques. Within this rapidly developing field, the precise role brain biopsy is unknown. We aimed to study clinical impact safety biopsies in unexplained CNS disorders. Methods In retrospective cohort study, we included all adult patients who were referred for a work‐up our academic center with neuro‐inflammatory, neuro‐oncological,...
<h3>Objective</h3> As autoimmune encephalitis (AIE) can resemble neurodegenerative dementia syndromes, and patients do not always present as encephalitis, this study evaluates how frequently AIE mimics provides red flags for in middle-aged older patients. <h3>Methods</h3> In nationwide observational cohort study, with anti–leucine-rich glioma-inactivated 1 (LGI1), anti–NMDA receptor (NMDAR), anti–gamma-aminobutyric acid B (GABA<sub>B</sub>R), or anti–contactin-associated protein-like 2...
Anti-NMDA receptor (anti-NMDAR) encephalitis generally manifests in young adults. Although 80%-90% returns to independence, the majority experience persistent cognitive and psychosocial difficulties. Studies have demonstrated that recovery may continue for years; temporal trajectory is largely unknown, as are factors influencing cognitive/psychosocial recovery. Objectives were (1) describe trajectory, (2) assess self-reported outcomes, (3) identify relating outcome, (4) explore relation...